Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Grzegorz Machnik"'
Autor:
Agnieszka Polak, Grzegorz Machnik, Łukasz Bułdak, Jarosław Ruczyński, Katarzyna Prochera, Oliwia Bujak, Piotr Mucha, Piotr Rekowski, Bogusław Okopień
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1463 (2024)
Proprotein convertase subtilisin/kexin 9 (PCSK9) is a protein that plays a key role in the metabolism of low-density lipoprotein (LDL) cholesterol. The gain-of-function mutations of the PCSK9 gene lead to a reduced number of surface LDL receptors by
Externí odkaz:
https://doaj.org/article/05ecf1f8957741d68f801333c6bdec69
Autor:
Marcin Basiak, Marcin Hachula, Michal Kosowski, Grzegorz Machnik, Mateusz Maliglowka, Maria Dziubinska-Basiak, Robert Krysiak, Boguslaw Okopien
Publikováno v:
Molecules, Vol 28, Iss 15, p 5928 (2023)
Atherosclerosis is a multifactorial, progressive, chronic inflammatory disease. Ultrasound and magnetic resonance imaging are the most accurate predictors of atherosclerotic plaque instability (MRI). Cytokines such as osteopontin, osteoprotegerin, an
Externí odkaz:
https://doaj.org/article/5da2f9b847b74eba9a260e81f8dc4ed7
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 922 (2023)
Metformin has been found to reduce elevated gonadotropin levels. Hashimoto’s thyroiditis is the most common thyroid disorder in iodine-sufficient areas, and it often develops in postmenopausal women. The aim of this study was to investigate whether
Externí odkaz:
https://doaj.org/article/da240efd63d74a588251adbe6273131d
Publikováno v:
Nutrients, Vol 15, Iss 10, p 2303 (2023)
Both hyperprolactinemia and vitamin D deficiency appear to be associated with increased cardiometabolic risk. This study aimed to determine whether vitamin D status influences the cardiometabolic effects of cabergoline. The study included three match
Externí odkaz:
https://doaj.org/article/e353436a97ad47f2b4bfcb5546fd5797
Autor:
Mateusz Maligłówka, Michał Kosowski, Marcin Hachuła, Marcin Cyrnek, Łukasz Bułdak, Marcin Basiak, Aleksandra Bołdys, Grzegorz Machnik, Rafał Jakub Bułdak, Bogusław Okopień
Publikováno v:
Metabolites, Vol 12, Iss 3, p 256 (2022)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells. This serine protease plays a pivotal role in the reduction of the number of low-de
Externí odkaz:
https://doaj.org/article/f3be353381554a89a259aa08885e5fae
Autor:
Ewa Obuchowicz, Anna Bielecka-Wajdman, Michał Zieliński, Grzegorz Machnik, Miłosz Gołyszny, Tomasz Ludyga
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Here, we examine the effects of prenatal administration of two antidepressants—imipramine (IMI) and venlafaxine (VEN)—on morphology and activity of a primary glial culture. Microglia are targeted by antidepressants used for antenatal depression a
Externí odkaz:
https://doaj.org/article/9dd2d1b928fc4b399781c4c15d9f2c0f
Autor:
Michał Kosowski, Joanna Smolarczyk-Kosowska, Marcin Hachuła, Mateusz Maligłówka, Marcin Basiak, Grzegorz Machnik, Robert Pudlo, Bogusław Okopień
Publikováno v:
Molecules, Vol 26, Iss 10, p 2838 (2021)
Statins are among the most widely used drug classes in the world. Apart from their basic mechanism of action, which is lowering cholesterol levels, many pleiotropic effects have been described so far, such as anti-inflammatory and antiatherosclerotic
Externí odkaz:
https://doaj.org/article/5a8a9cf0fb7e4b449fd794db4018cc7d
Autor:
Marcin Basiak, Michał Kosowski, Marcin Cyrnek, Łukasz Bułdak, Mateusz Maligłówka, Grzegorz Machnik, Bogusław Okopień
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3144 (2021)
Proprotein convertase subtilisin/kexin type 9 (PCSK-9) inhibitors are a group of drugs whose main mechanism of action is binding to the PCSK-9 molecule, which reduces the degradation of the low-density lipoprotein receptor (LDL-R) and, hence, increas
Externí odkaz:
https://doaj.org/article/85847f251a1e448c88a3f052531a61b2
Publikováno v:
Pharmaceuticals; Volume 16; Issue 7; Pages: 922
Metformin has been found to reduce elevated gonadotropin levels. Hashimoto’s thyroiditis is the most common thyroid disorder in iodine-sufficient areas, and it often develops in postmenopausal women. The aim of this study was to investigate whether
Autor:
Anna Maria Bielecka Wajdman, Grzegorz Machnik, Michael Linnebacher, Christina Linnebacher, Ewa Obuchowicz
Purpose Since recurrence is observed in almost all glioma patients deeper insight into mechanisms responsible for therapy resistance and identification of new biomarkers is urgently required. In this study were analyzed differences in expression of 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed0058f65417aa60850ac327877934e
https://doi.org/10.21203/rs.3.rs-2782714/v1
https://doi.org/10.21203/rs.3.rs-2782714/v1