Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Grzegorz M. Popowicz"'
Autor:
Stefan Gaussmann, Rebecca Peschel, Julia Ott, Krzysztof M. Zak, Judit Sastre, Florent Delhommel, Grzegorz M. Popowicz, Job Boekhoven, Wolfgang Schliebs, Ralf Erdmann, Michael Sattler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Import of proteins into peroxisomes depends on PEX5, PEX13 and PEX14. By combining biochemical methods and structural biology, we show that the C-terminal SH3 domain of PEX13 mediates intramolecular interactions with a proximal FxxxF motif.
Externí odkaz:
https://doaj.org/article/89d258036d6146bbb1acbb853157ad7f
Autor:
Fabian Giehler, Michael S. Ostertag, Thomas Sommermann, Daniel Weidl, Kai R. Sterz, Helmut Kutz, Andreas Moosmann, Stephan M. Feller, Arie Geerlof, Brigitte Biesinger, Grzegorz M. Popowicz, Johannes Kirchmair, Arnd Kieser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) drives viral B cell transformation and oncogenesis. LMP1’s transforming activity depends on its C-terminal activation region 2 (CTAR2), which induces NF-κB and JNK by engaging TNF
Externí odkaz:
https://doaj.org/article/6129e63ef175431f88dcfe4bca0f1328
Autor:
Katarzyna Pustelny, Przemyslaw Grygier, Agata Barzowska, Barbara Pucelik, Alex Matsuda, Krzysztof Mrowiec, Emilia Slugocka, Grzegorz M. Popowicz, Grzegorz Dubin, Anna Czarna
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract The selective inhibition of kinases from the diabetic kinome is known to promote the regeneration of beta cells and provide an opportunity for the curative treatment of diabetes. The effect can be achieved by carefully tailoring the selectiv
Externí odkaz:
https://doaj.org/article/019d5f10de1343a6be828ec08add5fc8
Autor:
Hristo L. Svilenov, Florent Delhommel, Till Siebenmorgen, Florian Rührnößl, Grzegorz M. Popowicz, Alwin Reiter, Michael Sattler, Carsten Brockmeyer, Johannes Buchner
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)
The solution structure, stability, and dynamics of a broadly-acting antiviral ACE2-IgG-Fc fusion protein are determined. Small chemical compounds binding to ACE2 can be used to drastically increase the thermal stability of the ACE2 domain.
Externí odkaz:
https://doaj.org/article/48b62d1ded4b445a8b83c2e98af549e2
Autor:
Valeria Napolitano, Charlotte A. Softley, Artur Blat, Vishal C. Kalel, Kenji Schorpp, Till Siebenmorgen, Kamyar Hadian, Ralf Erdmann, Michael Sattler, Grzegorz M. Popowicz, Grzegorz Dubin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Trypanosomiases are life-threatening infections of humans and livestock, and novel effective therapeutic approaches are needed. Trypanosoma compartmentalize glycolysis into specialized organelles termed glycosomes. Most of the trypanosomal g
Externí odkaz:
https://doaj.org/article/ab883f4a01d442d8963c7e6b3aaf0f64
Autor:
Alisha N. Jones, André Mourão, Anna Czarna, Alex Matsuda, Roberto Fino, Krzysztof Pyrc, Michael Sattler, Grzegorz M. Popowicz
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The replication complex (RC) of SARS-CoV-2 was recently shown to be one of the fastest RNA-dependent RNA polymerases of any known coronavirus. With this rapid elongation, the RC is more prone to incorporate mismatches during elongation, resu
Externí odkaz:
https://doaj.org/article/02bfc4b9af0e44b6a67b247f314fe0c8
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity
Autor:
Atilio Reyes Romero, Serjey Lunev, Grzegorz M. Popowicz, Vito Calderone, Matteo Gentili, Michael Sattler, Jacek Plewka, Michał Taube, Maciej Kozak, Tad A. Holak, Alexander S. S. Dömling, Matthew R. Groves
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Romero et al. perform NMR-based screening of 1500 fragments to identify fragments that bind at the oligomeric interface of malate dehydrogenase (MDH). Their study indicates an allosteric mechanism impacting enzymatic activity, paving the way for deve
Externí odkaz:
https://doaj.org/article/f14c722416964fa8b99c79a63335b872
Autor:
Filipe Menezes, Grzegorz M. Popowicz
Publikováno v:
Molecules, Vol 28, Iss 6, p 2841 (2023)
In this work, we study the buckycatcher (C60H28) in solution using quantum chemical models. We investigate the conformational equilibria in several media and the effects that molecules of solvent might have in interconversion barriers between the dif
Externí odkaz:
https://doaj.org/article/62f8e1e927bf46a1b71466800155b84d
Autor:
Krzysztof M. Zak, Mark J. Bostock, Irena Waligorska, Ida B. Thøgersen, Jan J. Enghild, Grzegorz M. Popowicz, Przemyslaw Grudnik, Jan Potempa, Miroslaw Ksiazek
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1267-1281 (2021)
Mirolysin is a secretory protease of Tannerella forsythia, a member of the dysbiotic oral microbiota responsible for periodontitis. In this study, we show that mirolysin latency is achieved by a “cysteine-switch” mechanism exerted by Cys23 in the
Externí odkaz:
https://doaj.org/article/facc41ee0c7f40019822708c69e05cfb
Autor:
Vishal C. Kalel, Leonidas Emmanouilidis, Maciej Dawidowski, Wolfgang Schliebs, Michael Sattler, Grzegorz M. Popowicz, Ralf Erdmann
Publikováno v:
Microbial Cell, Vol 4, Iss 7, Pp 229-232 (2017)
Vector-borne trypanosomatid parasite infections in tropical and sub-tropical countries constitute a major threat to humans and livestock. Trypanosoma brucei parasites are transmitted by tsetse fly and lead to African sleeping sickness in humans and N
Externí odkaz:
https://doaj.org/article/e88678ff3f46427197d710810053753b