Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Grzegorz J Grabe"'
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Methods for detecting and dissecting the interactions of virally encoded proteins are essential for probing basic viral biology and providing a foundation for therapeutic advances. The dearth of targeted therapeutics for the treatment of cor
Externí odkaz:
https://doaj.org/article/2b3aa4152b75417f93849cfd8f85d507
Autor:
Julian A. Rycroft, Bridget Gollan, Grzegorz J. Grabe, Alexander Hall, Angela M. Cheverton, Gerald Larrouy-Maumus, Stephen A. Hare, Sophie Helaine
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The recalcitrance of many infections to antibiotic treatment may be due to the presence of ‘persisters’, or non-growing, antibiotic-tolerant bacteria. Here, the authors study the structures and functions of aminoacyl-tRNA acetyltransferase toxins
Externí odkaz:
https://doaj.org/article/3bed1ef83f1d4e429b13f75bbb4a9545
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Nonflagellar type III secretion systems (nf T3SSs) form a cell surface needle-like structure and an associated translocon that deliver bacterial effector proteins into eukaryotic host cells. This involves a tightly regulated hierarchy of pro
Externí odkaz:
https://doaj.org/article/c3e4c1e85fce48b684b04a1bb4a34047
Autor:
Laurent Dubois, Sophie Helaine, Stephen A Hare, Alexander M J Hall, Rhodri M. L. Morgan, Tyler A Sisley, Rachel T. Giorgio, Grzegorz J Grabe, Julian A Rycroft
Publikováno v:
Nature Chemical Biology. 17:1296-1304
Toxin-antitoxin (TA) systems are a large family of genes implicated in the regulation of bacterial growth and its arrest in response to attacks. These systems encode nonsecreted toxins and antitoxins that specifically pair, even when present in sever
Autor:
Guilherme V, de Castro, Dennis J, Worm, Grzegorz J, Grabe, Fiona C, Rowan, Lucy, Haggerty, Ana L, de la Lastra, Oana, Popescu, Sophie, Helaine, Anna, Barnard
Publikováno v:
ACS chemical biology. 17(6)
In the search for novel antimicrobial therapeutics, toxin-antitoxin (TA) modules are promising yet underexplored targets for overcoming antibiotic failure. The bacterial toxin Doc has been associated with the persistence of
Autor:
Guilherme V. de Castro, Dennis J. Worm, Grzegorz J. Grabe, Fiona C. Rowan, Lucy Haggerty, Ana L. de la Lastra, Oana Popescu, Sophie Helaine, Anna Barnard
In the search for novel antimicrobial therapeutics, toxin-antitoxin (TA) modules are promising yet underexplored targets for overcoming antibiotic failure. The bacterial toxin Doc has been associated with the persistence of Salmonella in macrophages,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9405fd1500f3004ad7174b519a9fdaa
http://hdl.handle.net/10044/1/97563
http://hdl.handle.net/10044/1/97563
Publikováno v:
mBio
mBio, Vol 12, Iss 6 (2021)
mBio, Vol 12, Iss 6 (2021)
Methods for detecting and dissecting the interactions of virally encoded proteins are essential for probing basic viral biology and providing a foundation for therapeutic advances. The dearth of targeted therapeutics for the treatment of coronavirus
Methods for detecting and dissecting the interactions of virally encoded proteins are essential for probing basic viral biology and providing a foundation for therapeutic advances. The dearth of targeted therapeutics for the treatment of COVID-19, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::180a6614a820eb243495ea9c86904469
https://doi.org/10.1101/2021.10.07.463611
https://doi.org/10.1101/2021.10.07.463611
Autor:
Teige R. S. Matthews-Palmer, Tobias Zachs, Signe Lagercrantz, David W. Holden, Morgan Beeby, Sarah L. Rouse, Grzegorz J. Grabe, Peter B. Rosenthal, Andrea Nans, Thomas Calcraft, Nayim Gonzalez-Rodriguez, Xiu-Jun Yu
Publikováno v:
Journal of Structural Biology, 213 (2)
Journal of Structural Biology
Journal of Structural Biology
Bacterial type III secretion systems assemble the axial structures of both injectisomes and flagella. Injectisome type III secretion systems subsequently secrete effector proteins through their hollow needle into a host, requiring co-ordination. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2484726151891864fce4e7a97ebdba
https://hdl.handle.net/20.500.11850/498266
https://hdl.handle.net/20.500.11850/498266
Autor:
Krzysztof Rolka, Mateusz Heldt, Marta Jancz, Andrzej Hellmann, Miłosz Wieczór, Andrzej Skladanowski, Jan Lica, Katarzyna Gucwa, Anna Stupak, Majus Misiak, Wioletta Brankiewicz, Natalia Maciejewska, Maciej Baginski, Grzegorz J Grabe
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4931, p 4931 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences
Volume 22
Issue 9
Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug develo