Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Grzegorz A Czapski"'
Autor:
Grzegorz A Czapski, Magdalena Cieślik, Emilia Białopiotrowicz, Walter J Lukiw, Joanna B Strosznajder
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259740 (2021)
In the current study, we analyzed the effects of the systemic inflammatory response (SIR) and amyloid β (Aβ) peptide on the expression of genes encoding cyclins and cyclin-dependent kinase (Cdk) in: (i) PC12 cells overexpressing human beta amyloid
Externí odkaz:
https://doaj.org/article/8127807ac86f483683a94cab32ca2f3b
Publikováno v:
Folia Neuropathologica, Vol 62, Iss 2, Pp 127-135 (2024)
The neuroinflammation is a crucial component of virtually all neurodegenerative disorders, including Alzheimer’s disease (AD). The bacterial lipopolysaccharide (LPS), a potent activator of the innate immune system, was suggested to influence or eve
Externí odkaz:
https://doaj.org/article/62011e42640a4bb9963f78cda100833b
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137193 (2015)
Our study focused on the relationship between amyloid β 1-42 (Aβ), sphingosine kinases (SphKs) and mitochondrial sirtuins in regulating cell fate. SphK1 is a key enzyme involved in maintaining sphingolipid rheostat in the brain. Deregulation of the
Externí odkaz:
https://doaj.org/article/b32cbf3fa1da484caac4b45761a11b7d
Autor:
Magdalena Gąssowska, Grzegorz A Czapski, Beata Pająk, Magdalena Cieślik, Anna M Lenkiewicz, Agata Adamczyk
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94259 (2014)
α-Synuclein (ASN) plays an important role in pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. Novel and most interesting data showed elevated tauopathy in PD and suggested relationship between ASN and Tau protein. Howe
Externí odkaz:
https://doaj.org/article/7be7daaba4e5457298f6a40a8af5cf22
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7243 (2023)
Maternal immune activation (MIA) is an important risk factor for neurodevelopmental disorders such as autism. The aim of the current study was to investigate the development-dependent changes in the mitochondrial function of MIA-exposed offspring, wh
Externí odkaz:
https://doaj.org/article/3b5db6f8d5d3410f805770a3f0be30fb
Autor:
Magdalena Gąssowska-Dobrowolska, Grzegorz A. Czapski, Magdalena Cieślik, Karolina Zajdel, Małgorzata Frontczak-Baniewicz, Lidia Babiec, Agata Adamczyk
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7303 (2023)
Tuberous sclerosis complex (TSC) is a rare genetic multisystem disorder caused by loss-of-function mutations in the tumour suppressors TSC1/TSC2, both of which are negative regulators of the mammalian target of rapamycin (mTOR) kinase. Importantly, m
Externí odkaz:
https://doaj.org/article/94f6fe6186f24fa9a7100d975d473e93
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 13 (2022)
The correct phagocytic activity of microglia is a prerequisite for maintaining homeostasis in the brain. In the analysis of mechanisms regulating microglial phagocytosis, we focused on the bromodomain and extraterminal domain (BET) proteins: Brd2, Br
Externí odkaz:
https://doaj.org/article/c0b7106a33e041e984afe2325924915f
Autor:
Magdalena Cieślik, Magdalena Gassowska-Dobrowolska, Aleksandra Zawadzka, Małgorzata Frontczak-Baniewicz, Magdalena Gewartowska, Agnieszka Dominiak, Grzegorz A. Czapski, Agata Adamczyk
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders in offspring, but the pathomechanism is largely unknown. The aim of our study was to analyse the molecular mechanisms contributing to synaptic alterations in hippocamp
Externí odkaz:
https://doaj.org/article/0a515474976d413fa18d9a8f497e03f5
Autor:
Grzegorz A. Czapski, Lidia Babiec, Henryk Jęśko, Magdalena Gąssowska-Dobrowolska, Magdalena Cieślik, Marta Matuszewska, Małgorzata Frontczak-Baniewicz, Karolina Zajdel, Agata Adamczyk
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10058 (2021)
Tuberous sclerosis complex (TSC) is a rare, multi-system genetic disease with serious neurological and mental symptoms, including autism. Mutations in the TSC1/TSC2 genes lead to the overactivation of mTOR signalling, which is also linked to nonsyndr
Externí odkaz:
https://doaj.org/article/8eaf7a5dfed449ef961c261365dd94cb
Autor:
Magdalena Cieślik, Magdalena Gąssowska-Dobrowolska, Henryk Jęśko, Grzegorz A. Czapski, Anna Wilkaniec, Aleksandra Zawadzka, Agnieszka Dominiak, Rafał Polowy, Robert K. Filipkowski, Paweł M. Boguszewski, Magdalena Gewartowska, Małgorzata Frontczak-Baniewicz, Grace Y. Sun, David Q. Beversdorf, Agata Adamczyk
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4097 (2020)
Maternal immune activation (MIA), induced by infection during pregnancy, is an important risk factor for neuro-developmental disorders, such as autism. Abnormal maternal cytokine signaling may affect fetal brain development and contribute to neurobio
Externí odkaz:
https://doaj.org/article/d28eb6b7fa984da58d828160b28b1fc2