Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Grzegorz A Czapski"'
Publikováno v:
Folia Neuropathologica, Vol 62, Iss 2, Pp 127-135 (2024)
The neuroinflammation is a crucial component of virtually all neurodegenerative disorders, including Alzheimer’s disease (AD). The bacterial lipopolysaccharide (LPS), a potent activator of the innate immune system, was suggested to influence or eve
Externí odkaz:
https://doaj.org/article/62011e42640a4bb9963f78cda100833b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7243 (2023)
Maternal immune activation (MIA) is an important risk factor for neurodevelopmental disorders such as autism. The aim of the current study was to investigate the development-dependent changes in the mitochondrial function of MIA-exposed offspring, wh
Externí odkaz:
https://doaj.org/article/3b5db6f8d5d3410f805770a3f0be30fb
Autor:
Magdalena Gąssowska-Dobrowolska, Grzegorz A. Czapski, Magdalena Cieślik, Karolina Zajdel, Małgorzata Frontczak-Baniewicz, Lidia Babiec, Agata Adamczyk
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7303 (2023)
Tuberous sclerosis complex (TSC) is a rare genetic multisystem disorder caused by loss-of-function mutations in the tumour suppressors TSC1/TSC2, both of which are negative regulators of the mammalian target of rapamycin (mTOR) kinase. Importantly, m
Externí odkaz:
https://doaj.org/article/94f6fe6186f24fa9a7100d975d473e93
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 13 (2022)
The correct phagocytic activity of microglia is a prerequisite for maintaining homeostasis in the brain. In the analysis of mechanisms regulating microglial phagocytosis, we focused on the bromodomain and extraterminal domain (BET) proteins: Brd2, Br
Externí odkaz:
https://doaj.org/article/c0b7106a33e041e984afe2325924915f
Autor:
Magdalena Cieślik, Magdalena Gassowska-Dobrowolska, Aleksandra Zawadzka, Małgorzata Frontczak-Baniewicz, Magdalena Gewartowska, Agnieszka Dominiak, Grzegorz A. Czapski, Agata Adamczyk
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders in offspring, but the pathomechanism is largely unknown. The aim of our study was to analyse the molecular mechanisms contributing to synaptic alterations in hippocamp
Externí odkaz:
https://doaj.org/article/0a515474976d413fa18d9a8f497e03f5
Autor:
Grzegorz A. Czapski, Magdalena Cieślik, Emilia Białopiotrowicz, Walter J. Lukiw, Joanna B. Strosznajder
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
In the current study, we analyzed the effects of the systemic inflammatory response (SIR) and amyloid β (Aβ) peptide on the expression of genes encoding cyclins and cyclin-dependent kinase (Cdk) in: (i) PC12 cells overexpressing human beta amyloid
Externí odkaz:
https://doaj.org/article/fb2c608d737546b99b3dce65632b7ad0
Autor:
Anna Wilkaniec, Magdalena Gąssowska-Dobrowolska, Marcin Strawski, Agata Adamczyk, Grzegorz A. Czapski
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-18 (2018)
Abstract Background Cyclin-dependent kinase 5 (Cdk5) belongs to the family of proline-directed serine/threonine kinases and plays a critical role in neuronal differentiation, migration, synaptogenesis, plasticity, neurotransmission and apoptosis. The
Externí odkaz:
https://doaj.org/article/ceab238d0c8240d09f3c8fd9287ca4d3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11677 (2021)
The physiological balance between excitation and inhibition in the brain is significantly affected in Alzheimer’s disease (AD). Several neuroactive compounds and their signaling pathways through various types of receptors are crucial in brain homeo
Externí odkaz:
https://doaj.org/article/f7e2d4cad42643a1ba0a14d86c499bde
Autor:
Grzegorz A. Czapski, Lidia Babiec, Henryk Jęśko, Magdalena Gąssowska-Dobrowolska, Magdalena Cieślik, Marta Matuszewska, Małgorzata Frontczak-Baniewicz, Karolina Zajdel, Agata Adamczyk
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10058 (2021)
Tuberous sclerosis complex (TSC) is a rare, multi-system genetic disease with serious neurological and mental symptoms, including autism. Mutations in the TSC1/TSC2 genes lead to the overactivation of mTOR signalling, which is also linked to nonsyndr
Externí odkaz:
https://doaj.org/article/8eaf7a5dfed449ef961c261365dd94cb
Autor:
Anna Magdalena Lenkiewicz, Grzegorz Arkadiusz Czapski, Henryk Jęsko, Anna Wilkaniec, Wojciech Szypuła, Agnieszka Pietrosiuk, Aneta Marta Uszyńska, Agata Adamczyk
Publikováno v:
Folia Neuropathologica, Vol 54, Iss 2, Pp 156-166 (2016)
Imbalance between production and scavenging of free radicals and other reactive oxygen species (ROS) is a component of many diseases, but it is especially important in aging-related diseases of the central nervous system. Oxidative stress-induced neu
Externí odkaz:
https://doaj.org/article/099d2bbd9d4147b28e69ae84e495f662