Zobrazeno 1 - 10 of 136 pro vyhledávání: '"Grzegorz, Grynkiewicz"'
1
Akademický článek
New Perspectives for Fisetin
Autor: Grzegorz Grynkiewicz, Oleg M. Demchuk
Publikováno v: Frontiers in Chemistry, Vol 7 (2019)
Fisetin is a flavonol that shares distinct antioxidant properties with a plethora of other plant polyphenols. Additionally, it exhibits a specific biological activity of considerable interest as regards the protection of functional macromolecules aga
Externí odkaz: https://doaj.org/article/43d0a0a2f1e64bb1a381eadaf25fb3a3
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2
Akademický článek
Protective Effects of Vitamin K Compounds on the Proteomic Profile of Osteoblasts under Oxidative Stress Conditions
Autor: Marta Muszyńska, Ewa Ambrożewicz, Agnieszka Gęgotek, Grzegorz Grynkiewicz, Elżbieta Skrzydlewska
Publikováno v: Molecules, Vol 25, Iss 8, p 1990 (2020)
Oxidative stress, which accompanies the pathogenesis of many bone diseases, contributes to the reduction of osteoblast activity, resulting in the inhibition of differentiation. This study aimed to assess the effect of vitamins K1 and K2 (MK4 and MK7)
Externí odkaz: https://doaj.org/article/c488b14e072a48148f6cdf5492e2aafc
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3
Akademický článek
Synthetic Genistein Glycosides Inhibiting EGFR Phosphorylation Enhance the Effect of Radiation in HCT 116 Colon Cancer Cells
Autor: Aleksandra Gruca, Zdzisław Krawczyk, Wiesław Szeja, Grzegorz Grynkiewicz, Aleksandra Rusin
Publikováno v: Molecules, Vol 19, Iss 11, Pp 18558-18573 (2014)
The need to find new EGFR inhibitors for use in combination with radiotherapy in the treatment of solid tumors has drawn our attention to compounds derived from genistein, a natural isoflavonoid. The antiproliferative potential of synthetic genistein
Externí odkaz: https://doaj.org/article/683a05289a7d4fc8af81e479a8129083
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4
Akademický článek
Synthesis and Cytotoxicity of 2,3-Enopyranosyl C-Linked Conjugates of Genistein
Autor: Wieslaw Szeja, Grzegorz Grynkiewicz, Tadeusz Bieg, Piotr Swierk, Anna Byczek, Katarzyna Papaj, Radosław Kitel, Aleksandra Rusin
Publikováno v: Molecules, Vol 19, Iss 6, Pp 7072-7093 (2014)
A series of glycoconjugates, derivatives of genistein containing a C-glycosylated carbohydrate moiety, were synthesized and their anticancer activity was tested in vitro in the human cell lines HCT 116 and DU 145. The target compounds 15–17 were sy
Externí odkaz: https://doaj.org/article/73c89522c53a4f90a9b022dac9b5366f
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5
Akademický článek
Beneficial Effects of Vitamins K and D3 on Redox Balance of Human Osteoblasts Cultured with Hydroxyapatite-Based Biomaterials
Autor: Ewa Ambrożewicz, Marta Muszyńska, Grażyna Tokajuk, Grzegorz Grynkiewicz, Neven Žarković, Elżbieta Skrzydlewska
Publikováno v: Cells, Vol 8, Iss 4, p 325 (2019)
Hydroxyapatite-based biomaterials are commonly used in surgery to repair bone damage. However, the introduction of biomaterials into the body can cause metabolic alterations, including redox imbalance. Because vitamins D3 and K (K1, MK-4, MK-7) have
Externí odkaz: https://doaj.org/article/f29bec0093ad4134a8d8085a45800399
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6
Akademický článek
Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex
Autor: Krzysztof Woźniak, Oliwia Zegrocka-Stendel, Tomasz Giller, Piotr Cmoch, Maura Malińska, Katarzyna Koziak, Marta Łaszcz, Bogdan Zagrodzki, Kamil Jatczak, Mariusz M. Gruza, Grzegorz Grynkiewicz
Publikováno v: Molecules, Vol 18, Iss 4, Pp 4389-4402 (2013)
A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture—protoescigenin—was isolated and purified, in the form of its correspo
Externí odkaz: https://doaj.org/article/ade0c4da734d400aa8f28fba8adf5df3
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7
Furan platform chemicals beyond fuels and plastics
Autor: Roman Bielski, Grzegorz Grynkiewicz
Publikováno v: Green Chemistry. 23:7458-7487
Herein, we offer some perspective on the metamorphosis that has already begun to take place in substantial parts of the chemical industry, i.e., a switch from traditional resources such as crude oil to biomass. This change requires the workhorse of c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e18d88924cd869c8cf6ecb0c82492c5
https://doi.org/10.1039/d1gc02402g
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9
Dose‐linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children
Autor: Esther van Duijn, R. Colin Garner, Mark A. Turner, Bianca D van Groen, Saskia N. de Wildt, Catherijne A. J. Knibbe, Dick Tibboel, Wioleta Maruszak, Grzegorz Grynkiewicz, B. Kevin Park, Elke H. J. Krekels, Wouter H. J. Vaes, Lenne-Triin Kõrgvee
Publikováno v: British Journal of Clinical Pharmacology
British Journal of Clinical Pharmacology, 85, 2332-2340
British Journal of Clinical Pharmacology, 85(10), 2332-2340. Wiley-Blackwell Publishing Ltd
British Journal of Clinical Pharmacology, 10, 85, 2332-2340
British Journal of Clinical Pharmacology, 85(10), 2332-2340
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
British Journal of Clinical Pharmacology, 85, 10, pp. 2332-2340
AimsDrug disposition in children may vary from adults due to age‐related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose line
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b6b0924cb8ce5dec21918fa3c5a864
http://europepmc.org/articles/PMC6783587
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