New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties

Autor: Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M. Wierońska, Beata Duszyńska, Andrzej Pilc, Andrzej J. Bojarski

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 211-225 (2022)

Considering the allosteric regulation of mGlu receptors for potential therapeutic applications, we developed a group of 1,2,4-oxadiazole derivatives that displayed mGlu4 receptor positive allosteric modulatory activity (EC50 = 282–656 nM). Selectiv

Externí odkaz: https://doaj.org/article/986c7044b75f497b83b535e2846fde7c

Activation of Metabotropic Glutamate Receptor (mGlu2) and Muscarinic Receptors (M1, M4, and M5), Alone or in Combination, and Its Impact on the Acquisition and Retention of Learning in the Morris Water Maze, NMDA Expression and cGMP Synthesis

Autor: Kalinowski, Joanna M. Wierońska, Paulina Cieślik, Grzegorz Burnat, Leszek

Publikováno v: Biomolecules; Volume 13; Issue 7; Pages: 1064

The Morris water maze (MWM) is regarded as one of the most popular tests for detecting spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among the crucial factors involved in this type of learning. Muscarinic (M1, M4, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::b3976b80517c7966aa3fc39991db9044

Application of Alanine Scanning to Determination of Amino Acids Essential for Peptide Adsorption at the Solid/Solution Interface and Binding to the Receptor: Surface-Enhanced Raman/Infrared Spectroscopy versus Bioactivity Assays

Autor: Helena Domin, Marta Makowska, Grzegorz Burnat, Edyta Proniewicz, Adam Prahl, Izabela Małuch

Publikováno v: Journal of Medicinal Chemistry

The article describes the application of the alanine-scanning technique used in combination with Raman, surface-enhanced Raman, attenuated total reflection Fourier transform infrared, and surface-enhanced infrared absorption (SEIRA) spectroscopies, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce4120f36ab44e30d5aba9c907b199d
https://doi.org/10.1021/acs.jmedchem.1c00397

The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice

Autor: Agnieszka Pałucha-Poniewiera, Anna Rafało-Ulińska, Piotr Brański, Karolina Podkowa, Grzegorz Burnat

Publikováno v: Behavioural Pharmacology. 31:574-582

The chronic unpredictable mild stress (CUMS) model of depression in mice is a model commonly used to investigate stress-induced depressive-like behaviours. The duration of the stress-inducing procedure is variable, thus making it difficult to compare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a3e39474bd2f865993fc19ea9505de
https://doi.org/10.1097/fbp.0000000000000564

Nitric Oxide-Dependent Mechanisms Underlying MK-801- or Scopolamine-Induced Memory Dysfunction in Animals: Mechanistic Studies

Autor: Joanna M. Wierońska, Agata Płoska, Grzegorz Burnat, Adrianna Radulska, Leszek Kalinowski, Anna Siekierzycka, Piotr Brański, Paulina Cieślik

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12282, p 12282 (2021)

MK-801, an NMDA receptor antagonist, and scopolamine, a cholinergic receptor blocker, are widely used as tool compounds to induce learning and memory deficits in animal models to study schizophrenia or Alzheimer-type dementia (AD), respectively. Memo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63846aefc860804a4be2cd83eca9f922