Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gryte Satas"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Subclonal copy number alterations are a prevalent feature in tumors with high chromosomal instability and result in heterogeneous cancer cell populations with distinct phenotypes. However, the extent to which subclonal copy number alteration
Externí odkaz:
https://doaj.org/article/016f0a9687414f4ba21344c902418beb
Autor:
Jinghui Zhang, Michael A. Dyer, Benjamin J. Raphael, Alberto S. Pappo, James R. Downing, Richard K. Wilson, Elaine R. Mardis, Xiang Chen, Ludmil B. Alexandrov, John Easton, Michael N. Edmonson, Donald A. Yergeau, Heather L. Mulder, Daniel K. Putnam, Michael Rusch, Scott Newman, Gang Wu, Gryte Satas, Armita Bahrami, Xiaotu Ma, Samuel W. Brady
To investigate the genomic evolution of metastatic pediatric osteosarcoma, we performed whole-genome and targeted deep sequencing on 14 osteosarcoma metastases and two primary tumors from four patients (two to eight samples per patient). All four pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::291e7ed8712a1ece2b30312e662a669c
https://doi.org/10.1158/1541-7786.c.6541300
https://doi.org/10.1158/1541-7786.c.6541300
Autor:
Jinghui Zhang, Michael A. Dyer, Benjamin J. Raphael, Alberto S. Pappo, James R. Downing, Richard K. Wilson, Elaine R. Mardis, Xiang Chen, Ludmil B. Alexandrov, John Easton, Michael N. Edmonson, Donald A. Yergeau, Heather L. Mulder, Daniel K. Putnam, Michael Rusch, Scott Newman, Gang Wu, Gryte Satas, Armita Bahrami, Xiaotu Ma, Samuel W. Brady
Osteosarcoma clinical history and capture validation sequencing data. Supplementary Table S1. Sample and treatment information for relapsed osteosarcoma patients. Supplementary Table S2. SJOS0011101 SNVs detected by capture validation and tumor purit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76dbef3bc2181052065972df64c165b
https://doi.org/10.1158/1541-7786.22516159
https://doi.org/10.1158/1541-7786.22516159
Somatic copy number alterations drive aberrant gene expression in cancer cells. In tumors with high levels of chromosomal instability, subclonal copy number alterations (CNAs) are a prevalent feature which often result in heterogeneous cancer cell po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8ec129364a3f977b50917bc6e62f13c
https://doi.org/10.1101/2023.01.10.523464
https://doi.org/10.1101/2023.01.10.523464
Publikováno v:
Cell systems. 12(10)
Summary The cancer cell fraction (CCF), or proportion of cancerous cells in a tumor containing a single-nucleotide variant (SNV), is a fundamental statistic used to quantify tumor heterogeneity and evolution. Existing CCF estimation methods from bulk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1efdb9b713ea88c9b49adeac805101
https://pubmed.ncbi.nlm.nih.gov/34672959
https://pubmed.ncbi.nlm.nih.gov/34672959
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783030452568
RECOMB
RECOMB
Motivation: Single-cell DNA sequencing enables the measurement of somatic mutations in individual tumor cells, and provides data to reconstruct the evolutionary history of the tumor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abf600b4caed08e767da3d31a069371e
https://doi.org/10.1007/978-3-030-45257-5_35
https://doi.org/10.1007/978-3-030-45257-5_35
Autor:
Benjamin J. Raphael, Gryte Satas
Publikováno v:
Bioinformatics
Motivation Current technologies for single-cell DNA sequencing require whole-genome amplification (WGA), as a single cell contains too little DNA for direct sequencing. Unfortunately, WGA introduces biases in the resulting sequencing data, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ab6dbd6108b7db647b3bd47fdc0e62
https://doi.org/10.1093/bioinformatics/bty286
https://doi.org/10.1093/bioinformatics/bty286
MotivationSingle-cell DNA sequencing enables the measurement of somatic mutations in individual tumor cells, and provides data to reconstruct the evolutionary history of the tumor. Nearly all existing methods to construct phylogenetic trees from sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ce00995dda2251a65caa6e4975e515
https://doi.org/10.1101/840355
https://doi.org/10.1101/840355
Publikováno v:
RECOMB
Background: Determining the clonal composition and somatic evolution of a tumor greatly aids in accurate prognosis and effective treatment for cancer. In order to understand how a tumor evolves over time and/or in response to treatment, multiple rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d446e11b90242701def4528166ddd6b
Publikováno v:
Nature genetics
Metastasis is the migration of cancerous cells from a primary tumor to other anatomical sites. While metastasis was long thought to result from monoclonal seeding, or single cellular migrations, recent phylogenetic analyses of metastatic cancers have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d924710be4a29956a3a2f64c7b527637
https://pubmed.ncbi.nlm.nih.gov/29700472
https://pubmed.ncbi.nlm.nih.gov/29700472