Superiority of the Triple-Acting 5-HT 6 R/5-HT 3 R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT 6 R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats.

Autor: Grychowska K; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland., López-Sánchez U; Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France., Vitalis M; Molecular Mechanisms in Neurodegenerative Dementia (MMDN) Laboratory, University of Montpellier, EPHE-PSL, INSERM U1198, 34-095 Montpellier, France., Canet G; Faculty of Medicine, Laval University, CR-CHUQ, G1 V 4G2 Québec City (QC), Canada., Satała G; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-324 Kraków, Poland., Olejarz-Maciej A; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland., Gołębiowska J; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-324 Kraków, Poland., Kurczab R; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-324 Kraków, Poland., Pietruś W; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-324 Kraków, Poland., Kubacka M; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland., Moreau C; Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France., Walczak M; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland., Blicharz-Futera K; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland., Bento O; IBMM, Université de Montpellier, CNRS, ENSCM, 34-293 Montpellier, France.; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, 34-094 Montpellier, France., Bantreil X; IBMM, Université de Montpellier, CNRS, ENSCM, 34-293 Montpellier, France., Subra G; IBMM, Université de Montpellier, CNRS, ENSCM, 34-293 Montpellier, France., Bojarski AJ; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-324 Kraków, Poland., Lamaty F; IBMM, Université de Montpellier, CNRS, ENSCM, 34-293 Montpellier, France., Becamel C; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, 34-094 Montpellier, France., Zussy C; Molecular Mechanisms in Neurodegenerative Dementia (MMDN) Laboratory, University of Montpellier, EPHE-PSL, INSERM U1198, 34-095 Montpellier, France., Chaumont-Dubel S; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, 34-094 Montpellier, France., Popik P; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-324 Kraków, Poland., Nury H; Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000 Grenoble, France., Marin P; Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, 34-094 Montpellier, France., Givalois L; Molecular Mechanisms in Neurodegenerative Dementia (MMDN) Laboratory, University of Montpellier, EPHE-PSL, INSERM U1198, 34-095 Montpellier, France.; Faculty of Medicine, Laval University, CR-CHUQ, G1 V 4G2 Québec City (QC), Canada.; CNRS, 75-016 Paris, France., Zajdel P; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 14928-14947. Date of Electronic Publication: 2023 Oct 05.

Early 5-HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse.

Autor: Berthoux C, Hamieh AM, Rogliardo A, Doucet EL, Coudert C, Ango F, Grychowska K, Chaumont-Dubel S, Zajdel P, Maldonado R, Bockaert J, Marin P, Bécamel C

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2022 Sep 07; Vol. 14 (9), pp. e16481.

Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT 3 and 5-HT 6 Receptor Antagonist with Antipsychotic and Procognitive Properties.

Autor: Zajdel P; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland., Grychowska K; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland., Mogilski S; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland., Kurczab R; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland., Satała G; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland., Bugno R; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland., Kos T; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland., Gołębiowska J; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland., Malikowska-Racia N; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland., Nikiforuk A; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland., Chaumont-Dubel S; Institut de Génomique Fonctionelle, Université de Montpellier, CNRS, INSERM, 34094 Montpellier, France., Bantreil X; IBMM, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France., Pawłowski M; Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland., Martinez J; IBMM, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France., Subra G; IBMM, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France., Lamaty F; IBMM, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France., Marin P; Institut de Génomique Fonctionelle, Université de Montpellier, CNRS, INSERM, 34094 Montpellier, France., Bojarski AJ; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland., Popik P; Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smętna Str., 31-343 Kraków, Poland.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Sep 23; Vol. 64 (18), pp. 13279-13298. Date of Electronic Publication: 2021 Sep 01.

Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases.

Autor: Xing, Cencan^1,2 (AUTHOR) cencanxing@ustb.edu.cn, Chen, Hongyu^1,2 (AUTHOR) 13907592802@163.com, Bi, Wangyu^1,2 (AUTHOR) biwangyu@163.com, Lei, Tong² (AUTHOR), Hang, Zhongci^1,2 (AUTHOR) zhongci-hang@xs.ustb.edu.cn, Du, Hongwu^1,2 (AUTHOR) hongwudu@ustb.edu.cn

Publikováno v: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13446. 20p.

A dual-acting 5-HT 6 receptor inverse agonist/MAO-B inhibitor displays glioprotective and pro-cognitive properties.

Autor: Canale V; Jagiellonian University Medical College, Department of Medicinal Chemistry, 9 Medyczna Str., 30-688, Kraków, Poland., Grychowska K; Jagiellonian University Medical College, Department of Medicinal Chemistry, 9 Medyczna Str., 30-688, Kraków, Poland., Kurczab R; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, 12 Smętna Str., 31-324, Kraków, Poland., Ryng M; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, 12 Smętna Str., 31-324, Kraków, Poland., Keeri AR; Jagiellonian University Medical College, Department of Medicinal Chemistry, 9 Medyczna Str., 30-688, Kraków, Poland., Satała G; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, 12 Smętna Str., 31-324, Kraków, Poland., Olejarz-Maciej A; Jagiellonian University Medical College, Department of Technology and Biotechnology of Drugs, 9 Medyczna Str., 30-688, Kraków, Poland., Koczurkiewicz P; Jagiellonian University Medical College, Department of Pharmaceutical Biochemistry, 9 Medyczna Str., 30-688, Kraków, Poland., Drop M; Jagiellonian University Medical College, Department of Medicinal Chemistry, 9 Medyczna Str., 30-688, Kraków, Poland., Blicharz K; Jagiellonian University Medical College, Department of Medicinal Chemistry, 9 Medyczna Str., 30-688, Kraków, Poland., Piska K; Jagiellonian University Medical College, Department of Pharmaceutical Biochemistry, 9 Medyczna Str., 30-688, Kraków, Poland., Pękala E; Jagiellonian University Medical College, Department of Pharmaceutical Biochemistry, 9 Medyczna Str., 30-688, Kraków, Poland., Janiszewska P; Jagiellonian University Medical College, Department of Toxicology, 9 Medyczna Str., 30-688, Kraków, Poland., Krawczyk M; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of New Drug Development, 12 Smętna Str., 31-324, Kraków, Poland., Walczak M; Jagiellonian University Medical College, Department of Toxicology, 9 Medyczna Str., 30-688, Kraków, Poland., Chaumont-Dubel S; Institut de Génomique Fonctionelle, Université de Montpellier, CNRS INSERM, 34094, Montpellier, France., Bojarski AJ; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, 12 Smętna Str., 31-324, Kraków, Poland., Marin P; Institut de Génomique Fonctionelle, Université de Montpellier, CNRS INSERM, 34094, Montpellier, France., Popik P; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of New Drug Development, 12 Smętna Str., 31-324, Kraków, Poland., Zajdel P; Jagiellonian University Medical College, Department of Medicinal Chemistry, 9 Medyczna Str., 30-688, Kraków, Poland. Electronic address: pawel.zajdel@uj.edu.pl.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2020 Dec 15; Vol. 208, pp. 112765. Date of Electronic Publication: 2020 Aug 22.