Large-scale analysis of whole genome sequencing data from formalin-fixed paraffin-embedded cancer specimens demonstrates preservation of clinical utility.

Autor: Basyuni S; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Heskin L; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Degasperi A; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Black D; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Koh GCC; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Chmelova L; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Rinaldi G; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Bell S; Precision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Grybowicz L; Cambridge Cancer Trials Centre, Department of Oncology, Cambridge University Hospitals, Cambridge, UK., Elgar G; Genomics England, One Canada Square, London, UK., Memari Y; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Robbe P; Department of Oncology, University of Oxford, Oxford, UK.; RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan., Kingsbury Z; Illumina Cambridge, Ltd, Illumina Centre, Cambridge, UK., Caldas C; Cancer Research UK Cambridge Centre, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Abraham J; Precision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Schuh A; Department of Oncology, University of Oxford, Oxford, UK., Jones L; Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK., Tischkowitz M; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK., Brown MA; Department of Oncology, University of Oxford, Oxford, UK., Davies HR; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Nik-Zainal S; Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK. sn206@cam.ac.uk.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK. sn206@cam.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 04; Vol. 15 (1), pp. 7731. Date of Electronic Publication: 2024 Sep 04.

The PARTNER trial of neoadjuvant olaparib with chemotherapy in triple-negative breast cancer.

Autor: Abraham JE; Precision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK. ja344@cam.ac.uk.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK. ja344@cam.ac.uk., Pinilla K; Precision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK., Dayimu A; Cambridge Cancer Trials Centre, University of Cambridge, Cambridge, UK., Grybowicz L; Cambridge Cancer Trials Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Demiris N; Department of Statistics, Athens University of Economics and Business, Athens, Greece., Harvey C; Cambridge Cancer Trials Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Drewett LM; Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK., Lucey R; Precision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK., Fulton A; Precision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK., Roberts AN; Cambridge Cancer Trials Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Worley JR; Precision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK., Chhabra A; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Qian W; Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Vallier AL; Cambridge Cancer Trials Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Hardy RM; Cambridge Cancer Trials Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Chan S; The City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK., Hickish T; Royal Bournemouth General Hospital, Bournemouth, UK., Tripathi D; Royal Wolverhampton NHS Trust, Wolverhampton, UK.; Russells Hall Hospital, Dudley, UK., Venkitaraman R; Ipswich Hospital, East Suffolk and North Essex NHS Foundation Trust, Ipswich, UK., Persic M; University Hospital of Derby and Burton, Derby, UK., Aslam S; Bedford Hospital, Bedfordshire Hospitals NHS Foundation Trust, Bedford, UK., Glassman D; Pinderfields Hospital, Mid Yorkshire Teaching NHS Trust, Wakefield, UK., Raj S; University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Basingstoke & North Hampshire Hospital, Basingstoke, UK.; Royal Hampshire Hospital, Winchester, UK., Borley A; Velindre Cancer Centre, Cardiff, UK., Braybrooke JP; University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK., Sutherland S; Mount Vernon Cancer Centre, Northwood, UK., Staples E; Queens Hospital, Barking, Havering and Redbridge University Hospitals NHS Trust, Romford, UK., Scott LC; Beatson West Of Scotland Cancer Centre, Glasgow, UK., Davies M; Swansea Bay University Health Board, Swansea, UK., Palmer CA; Hinchingbrooke Hospital, North West Anglia NHS Foundation Trust, Huntingdon, UK., Moody M; Macmillan Unit, West Suffolk Hospital NHS Foundation Trust, Bury Saint Edmunds, UK., Churn MJ; Worcestershire Acute Hospitals NHS Trust, Worcester, UK.; Alexandra Redditch Hospital, Redditch, UK.; Kidderminster Hospital, Kidderminster, Worcestershire, UK., Newby JC; Royal Free London NHS Foundation Trust, London, UK., Mukesh MB; Oncology Department, Colchester General Hospital, East Suffolk & North Essex NHS Trust, Colchester, UK., Chakrabarti A; University Hospitals Dorset NHS Foundation Trust, Poole, UK., Roylance RR; University College London Hospitals NHS Foundation Trust, London, UK., Schouten PC; Department of Histopathology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Levitt NC; Oxford University Hospital NHS Foundation Trust, Oxford, UK., McAdam K; Peterborough City Hospital, North West Anglia NHS Foundation Trust, Peterborough, UK., Armstrong AC; The Christie NHS Foundation Trust and Division of Cancer Sciences, Manchester, UK., Copson ER; Cancer Sciences Academic Unit, University of Southampton, Southampton, UK., McMurtry E; EMC2 Clinical Consultancy, Sale, Manchester, UK., Tischkowitz M; Department of Medical Genetics, National Institute for Health Research, Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK., Provenzano E; Department of Histopathology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Earl HM; Precision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK.

Publikováno v: Nature [Nature] 2024 May; Vol. 629 (8014), pp. 1142-1148. Date of Electronic Publication: 2024 Apr 08.

Impact of Molecular Profiling on Therapy Management in Breast Cancer.

Autor: Ultimescu, Flavia^1,2 (AUTHOR) flavia.ultimescu@gmail.com, Hudita, Ariana^3,4 (AUTHOR) ariana.hudita@bio.unibuc.ro, Popa, Daniela Elena⁵ (AUTHOR) ariana.hudita@bio.unibuc.ro, Olinca, Maria^1,6 (AUTHOR) maria.olinca@umfcd.ro, Muresean, Horatiu Alin¹ (AUTHOR) horatiu.alin.muresean@gmail.com, Ceausu, Mihail⁶ (AUTHOR), Stanciu, Diana Iuliana³ (AUTHOR) bianca.galateanu@bio.unibuc.ro, Ginghina, Octav^7,8 (AUTHOR) octav.ginghina@umfcd.ro, Galateanu, Bianca³ (AUTHOR)

Publikováno v: Journal of Clinical Medicine. Sep2024, Vol. 13 Issue 17, p4995. 35p.

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Central pathology review with two-stage quality assurance for pathological response after neoadjuvant chemotherapy in the ARTemis Trial.

Autor: Thomas JSJ; Department of Pathology, Western General Hospital, Edinburgh, UK., Provenzano E; NIHR Cambridge Biomedical Research Centre, Addenbrookes Hospital, Cambridge, UK.; Cambridge Breast Cancer Research Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Histopathology, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Hiller L; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Dunn J; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Blenkinsop C; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Grybowicz L; Cambridge Clinical Trials Unit-Cancer Theme, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Vallier AL; Cambridge Clinical Trials Unit-Cancer Theme, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Gounaris I; The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust, King's Lynn, UK., Abraham J; NIHR Cambridge Biomedical Research Centre, Addenbrookes Hospital, Cambridge, UK.; Cambridge Breast Cancer Research Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; University of Cambridge, Department of Oncology, Addenbrooke's Hospital, Cambridge, UK., Hughes-Davies L; University of Cambridge, Department of Oncology, Addenbrooke's Hospital, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., McAdam K; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Peterborough City Hospital, Edith Cavell Campus, Peterborough, UK., Chan S; Nottingham University Hospital (City Campus), Nottingham, UK., Ahmad R; West Middlesex University Hospital, Isleworth, UK., Hickish T; Poole Hospital NHS Foundation Trust, Poole, UK.; Bournemouth University, Poole, UK., Houston S; The Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK., Rea D; Institute for Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Caldas C; NIHR Cambridge Biomedical Research Centre, Addenbrookes Hospital, Cambridge, UK.; Cambridge Breast Cancer Research Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; University of Cambridge, Department of Oncology, Addenbrooke's Hospital, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK., Bartlett JM; Ontario Institute for Cancer Research, MaRS Centre, Toronto, ON, Canada., Cameron DA; University of Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh, UK., Hayward RL; Department of Medical Oncology, NHS Lothian, Western General Hospital, Edinburgh, UK., Earl HM; NIHR Cambridge Biomedical Research Centre, Addenbrookes Hospital, Cambridge, UK.; Cambridge Breast Cancer Research Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; University of Cambridge, Department of Oncology, Addenbrooke's Hospital, Cambridge, UK.

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2017 Aug; Vol. 30 (8), pp. 1069-1077. Date of Electronic Publication: 2017 May 26.