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Akademický článek

TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

Autor: Bhaskar Saha, Hallvard Olsvik, Geneva L. Williams, Seeun Oh, Gry Evjen, Eva Sjøttem, Michael A. Mandell

Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114294- (2024)

Summary: Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to mitophagy is unknown. Here, we show that K63-linked polyubiqui

Externí odkaz: https://doaj.org/article/2b59be1f76c84ab6a3436479a5b94c96

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TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Autor: Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

Publikováno v: Zhou, J, Rasmussen, N L, Olsvik, H L, Akimov, V, Hu, Z, Evjen, G, Kaeser-Pebernard, S, Sankar, D S, Roubaty, C, Verlhac, P, van de Beck, N, Reggiori, F, Abudu, Y P, Blagoev, B, Lamark, T, Johansen, T & Dengjel, J 2023, ' TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1 ', The Journal of Cell Biology, vol. 222, no. 2, e202108144 . https://doi.org/10.1083/jcb.202108144
The Journal of Cell Biology, 222(2):e202108144. ROCKEFELLER UNIV PRESS

Limitation of excessive inflammation due to selective degradation of pro-inflammatory proteins is one of the cytoprotective functions attributed to autophagy. In the current study, we highlight that selective autophagy also plays a vital role in prom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b5e9da72de2c41f9e73e7169bb3b4a
https://pure.au.dk/portal/da/publications/tbk1-phosphorylation-activates-lirdependent-degradation-of-the-inflammation-repressor-tnip1(eb658081-c42c-4782-bb7c-c9c2a3a1dd66).html

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SIRT1 is downregulated by autophagy in senescence and ageing

Autor: Parinaz Fozouni, Vemika Chandra, Congcong Lu, Lu Wang, Jing Jiang, Caiyue Xu, Corey Bretz, Melanie Ott, Terje Johansen, Peter D. Adams, Jeffrey D. Winkler, Ravi K. Amaravadi, Shelley L. Berger, Gry Evjen, Michael C. Nicastri, Zhixun Dou, Wei Tong, Benjamin A. Garcia

Publikováno v: Nature cell biology, vol 22, iss 10
Nature cell biology

SIRT1 (Sir2) is an NAD+-dependent deacetylase that plays critical roles in a broad range of biological events, including metabolism, the immune response and ageing1,2,3,4,5. Although there is strong interest in stimulating SIRT1 catalytic activity, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2cf4446e5fa5dd1ffb2a316b8adb87
https://doi.org/10.1038/s41556-020-00579-5

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TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Autor: Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d661637a8669dd2524ee9887ce98d638
https://doi.org/10.1101/2022.03.02.482646

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Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs

Autor: Zambarlal Bhujabal, Martina Wirth, Eva Sjøttem, Nicola O’Reilly, Stephane Mouilleron, Trond Lamark, Terje Johansen, Wenxin Zhang, Sharon A. Tooze, Rebecca Lee, Gry Evjen, Åsa Birna Birgisdottir

Publikováno v: Autophagy

Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888cc2b7655db9a71400380c498e8a13

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FYCO1 contains a C-terminally extended, LC3A/B-preferring LC3-interacting region (LIR) motif required for efficient maturation of autophagosomes during basal autophagy

Autor: Tsunehiro Mizushima, Hallvard Lauritz Olsvik, Terje Johansen, Kenneth Bowitz Larsen, Gry Evjen, Kenji Takagi, Trond Lamark, Aud Øvervatn

FYCO1 (FYVE and coiled-coil protein 1) is a transport adaptor that binds to phosphatidylinositol 3-phosphate, to Rab7, and to LC3 (microtubule-associated protein 1 light chain 3) to mediate transport of late endosomes and autophagosomes along microtu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d110a1e49084f369b8f35980d0c9a539
https://hdl.handle.net/10037/24845

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Mannose-receptor-mediated clearance of lysosomal α-mannosidase in scavenger endothelium of cod endocardium

Autor: Bård Smedsrød, Gry Evjen, Karen K Sørensen, Ole K. Tollersrud

Publikováno v: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 129:615-630

Mannose-receptor-mediated clearance of circulating glycoproteins was studied in Atlantic cod ( Gadus morhua ) . Distribution studies with radioiodinated and fluorescently labelled ligands showed that cod liver lysosomal α-mannosidase and yeast inver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8717ed585d9d505bd6a3d3a83e4a19dd
https://doi.org/10.1016/s1095-6433(01)00300-2

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Bovine brain myelin glycerophosphocholine choline phosphodiesterase is an alkaline lysosphingomyelinase of the eNPP-family, regulated by lysosomal sorting

Autor: Ole K. Greiner-Tollersrud, Thomas Berg, Linn Greiner-Tollersrud, Gry Evjen, Hilde Monica Frostad Riise Stensland

Publikováno v: Neurochemical research. 38(2)

Glycerophosphocholine choline phosphodiesterase (GPC-Cpde) is a glycosylphosphatidylinositol (GPI)-anchored alkaline hydrolase that is expressed in the brain and kidney. In brain the hydrolase is synthesized by the oligodendrocytes and expressed on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2846555cfd9ace63574998d5e18a06f
https://pubmed.ncbi.nlm.nih.gov/23161088

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Characterization of the carbohydrate moiety of human γ-glutamyltransferases using lectin-blotting and glycosidase treatment

Autor: Nils-Erik Huseby, Gry Evjen

Publikováno v: Clinica Chimica Acta. 209:27-34

The presence of both N- and O-linked carbohydrate was demonstrated on γ-glutamyltransferase (GT) from human liver and kidney. The N-linked carbohydrate constituted 25–30% of the total molecular mass of the enzymes. O-Glycosylation was detected on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc885570f629c348dbd2ec7eee26e1a9
https://doi.org/10.1016/0009-8981(92)90330-s

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Site-specific glycosylation analysis of the bovine lysosomal alpha-mannosidase

Autor: Ole-Kristian Tollersrud, Gry Evjen, Jean-Claude Michalski, Willy Morelle, Valegh Faid

Publikováno v: Glycobiology. 16(5)

Lysosomal alpha-mannosidase is a broad specificity exoglycosidase involved in the ordered degradation of glycoproteins. The bovine enzyme is used as an important model for understanding the inborn lysosomal storage disorder alpha-mannosidosis. This e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b2360aff4d582aa48a6bc6b5fa551b
https://pubmed.ncbi.nlm.nih.gov/16449350

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