Cohort profile

Autor: Biljana, Gigic, Eline, van Roekel, Andreana N, Holowatyj, Stefanie, Brezina, Anne J M R, Geijsen, Arve, Ulvik, Jennifer, Ose, Janna L, Koole, Victoria, Damerell, Rama, Kiblawi, Tanja, Gumpenberger, Tengda, Lin, Gry, Kvalheim, Torsten, Koelsch, Dieuwertje E, Kok, Franzel J, van Duijnhoven, Martijn J, Bours, Andreas, Baierl, Christopher I, Li, William, Grady, Kathy, Vickers, Nina, Habermann, Martin, Schneider, Ellen, Kampman, Per Magne, Ueland, Alexis, Ulrich, Matty, Weijenberg, Andrea, Gsur, Cornelia, Ulrich

Publikováno v: BMJ Open, 12(12)
BMJ Open 12 (2022) 12
BMJ Open, 12(12):e062930. BMJ Publishing Group

PurposeThe overarching goal of the FOCUS (biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer (CRC) recurrence and survival) Consortium is to unravel the effect of folate and folate-mediated one-carbon metabolism (FOCM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fd4931e39989586077819f9a6e3566
https://doi.org/10.1136/bmjopen-2022-062930

Circulating Folate and Folic Acid Concentrations: Associations With Colorectal Cancer Recurrence and Survival

Autor: Matty P. Weijenberg, Per Magne Ueland, Jolanta Jedrzkiewicz, Stephanie O. Breukink, Jennifer Ose, Petra Schrotz-King, Jenny Chang-Claude, F. Jeroen Vogelaar, Anne J.M.R. Geijsen, Torsten Kölsch, Alexis Ulrich, Peter Schirmacher, Fränzel J.B. van Duijnhoven, Janna L. Koole, Tengda Lin, Biljana Gigic, Johannes H. W. de Wilt, Courtney L. Scaife, Eric T.P. Keulen, Flip M. Kruyt, Eline H. van Roekel, William M. Grady, Dieuwertje E. Kok, Ellen Kampman, Martijn J.L. Bours, Henk K. van Halteren, Tanja Gumpenberger, Martin Schneider, Michael Hoffmeister, Cornelia M. Ulrich, Mary P. Bronner, Andreas Baierl, Katharina Kosma, Nina Habermann, Rama Kiblawi, Eric R. Swanson, Gry Kvalheim, Moniek van Zutphen, Andrea Gsur, Marie C Singer, Arve Ulvik, Evertine Wesselink, Hermann Brenner, Ewout A. Kouwenhoven, T Bartley Pickron, Peter van Duijvendijk, Jürgen Böhm, Andreana N. Holowatyj, Kathy Vickers, Stefanie Brezina, Esther Herpel, Christopher I. Li, Thomas Grünberger, Lyen C. Huang, Michael Bergmann

Publikováno v: JNCI Cancer Spectrum, 4
JNCI Cancer Spectrum, 4, 5
JNCI Cancer Spectrum, 4(5)
JNCI Cancer Spectrum, 4(5):051. Oxford University Press
JNCI Cancer Spectrum
JNCI Cancer Spectrum 4 (2020) 5

Background Folates, including folic acid, may play a dual role in colorectal cancer development. Folate is suggested to be protective in early carcinogenesis but could accelerate growth of premalignant lesions or micrometastases. Whether circulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb749cdfe9b73207d94bfe60e4db29c
https://doi.org/10.1093/jncics/pkaa051

Combined Measurement of 6 Fat-Soluble Vitamins and 26 Water-Soluble Functional Vitamin Markers and Amino Acids in 50 μL of Serum or Plasma by High-Throughput Mass Spectrometry

Autor: Ove Aarseth, Gry Kvalheim, Adrian McCann, Øivind Midttun, Per Magne Ueland, Klaus Meyer, Marit Krokeide

Publikováno v: Analytical chemistry. 88(21)

Targeted metabolic profiling characterized by complementary platforms, multiplexing and low volume consumption are increasingly used for studies using biobank material. Using liquid-liquid extraction, we developed a sample workup suitable for quantif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbccdfe2b39efa8d5a5215ee9ccaddcd
https://pubmed.ncbi.nlm.nih.gov/27715010

Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas

Autor: Gry Kvalheim, Henk J. Blom, Øivind Midttun, Akke Botma, Audrey Y. Jung, Ellen Kampman, Carolien Lute, Per Magne Ueland, Wilma T. Steegenga, Fokko M. Nagengast

Publikováno v: Jung, A Y, Botma, A, Lute, C, Blom, H J, Ueland, P M, Kvalheim, G, Midttun, O, Nagengast, F, Steegenga, W & Kampman, E 2013, ' Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas ', Molecular Nutrition and Food Research, vol. 57, no. 4, pp. 698-708 . https://doi.org/10.1002/mnfr.201200069
Molecular Nutrition & Food Research, 57(4), 698-708
Molecular Nutrition & Food Research (Formerly Nahrung/Food), 57, 4, pp. 698-708
Molecular Nutrition & Food Research 57 (2013) 4
Molecular Nutrition and Food Research, 57(4), 698-708. Wiley-VCH Verlag
Molecular Nutrition & Food Research (Formerly Nahrung/Food), 57, 698-708

Item does not contain fulltext SCOPE: Low concentrations of folate, other B vitamins, and methionine are associated with colorectal cancer risk, possibly by changing DNA methylation patterns. Here, we examine whether plasma concentrations of B vitami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4e8a4fec0d688fe285b0656d92cfe8
https://pubmed.ncbi.nlm.nih.gov/23132835

Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry

Autor: Gry Kvalheim, Amrei Windelberg, Per Magne Ueland, Ove Årseth

Publikováno v: Clinical chemistry. 51(11)

Background: The combined measurement of methylmalonic acid (MMA) and total homocysteine (tHcy) in serum or plasma is useful in diagnosing and distinguishing between cobalamin and folate deficiencies. We developed and validated an isotope-dilution gas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad78f9d24ae5b1a06727c8d1f586714e
https://pubmed.ncbi.nlm.nih.gov/16123148