Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Grozinger Karl G"'
Autor:
Considine, Kelly L., Stefanidis, Lazaros, Grozinger, Karl G., Audie, Joseph, Alper, Benjamin J.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 March 2017 27(6):1335-1340
Autor:
Wayne T. Stolle, Chris H. Senanayake, Grozinger Karl G, John A. Easter, Matt Hrapchak, Bachir Latli, Dhileepkumar Krishnamurthy
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 51:314-320
Tipranavir or Aptivus® is a non-peptidic protease inhibitor approved for the combination treatment with ritonavir of HIV infection. Tipranavir labeled with radioactive and stable isotopes of carbon was required for drug metabolism (excretion, distri
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Autor:
Heidi Heimroth, James Gillard, Pierre L. Beaulieu, and Ioannis Houpis, Vittorio Farina, Bruno Simoneau, Colette Boucher, Jürgen Schnaubelt, Xiao-Jun Wang, and Jean-Simon Duceppe, and Thomas Krueger, Grozinger Karl G, Murray D. Bailey, Li Zhang
Publikováno v:
The Journal of Organic Chemistry. 70:5869-5879
(1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic acid (vinyl-ACCA) is a key building block in the synthesis of potent inhibitors of the hepatitis C virus NS3 protease such as BILN 2061, which was recently shown to dramatically reduce viral load after ad
Autor:
Kirrane Thomas M, Xiao-Jun Wang, John R. Proudfoot, Jonathan Tan, Grozinger Karl G, Raj Betageri
Publikováno v:
Tetrahedron Letters. 41:5321-5324
3-Aryl-5-alkylpyrazoles undergo a highly regioselective arylation on N-1 atom with 4-fluoronitrobenzene in the presence of base to yield the corresponding 1-(4-nitrophenyl)pyrazoles.
Publikováno v:
Tetrahedron Letters. 41:4713-4716
The cross-coupling of 1-aryl-5-bromopyrazoles 4 with alkynes, vinyltins and arylboronic acids promoted by Pd(PPh3)4 afforded unsymmetrical 3,5-disubstituted 1-arylpyrazoles 5-8 in excellent yields. 1-Aryl-5-bromopyrazoles 4 were prepared from their c
Publikováno v:
Journal of Heterocyclic Chemistry. 37:229-239
Nevirapine (1) is a non-nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune® since 1996. In vitro studies of nevirapine biotransformation using human liver microsomes demonstrated the formation o
Publikováno v:
Tetrahedron Letters. 39:6609-6612
Secondary phenethylcarbamates undergo a Bischler-Napieralski cyclization promoted by phosphorus pentoxide in refluxing phosphorus oxychloride to afford N-alkylated 3,4-dihydroisoquinolones in high yields.
Autor:
Victor Fuchs, Jana Vitous, K. D. Hargrave, S. C. Mauldin, Grozinger Karl G, Scot Campbell, Julian Adams
Publikováno v:
Journal of Heterocyclic Chemistry. 32:259-263
Several synthetic methods were developed during the process optimization for the large scale synthesis of nevirapine (1), a non-nucleoside inhibitor of HIV-1 Reverse Transcriptase. The synthesis of its putative major metabolite 11-cyclopropyl-5,11-di
Publikováno v:
ChemInform. 24