Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Grove Simon James Anthony"'
Autor:
Ronald Palin, Hardy Sundaram, Philip S. Jones, David Vrolijk, Louise Evans, Mark A. Weston, David R. Barn, Grove Simon James Anthony, Helen Feilden, John K. Clark, J. Cottney, Marc Crockatt, Alasdair R.C. Smith, Grant Wishart, Paul Wren, Phillip M. Cowley, Richard Morphy, Frank Griekspoor, Richard R. Goodwin, Andrea K. Houghton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:589-593
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
Publikováno v:
Tetrahedron Letters. 42:8897-8899
A reaction between γ-cyclodextrin (γ-CD) and 2,4,6-triisopropylbenzenesulfonyl chloride in pyridine gave mono-6-( O -2,4,6-triisopropylbenzenesulfonyl)-γ-cyclodextrin in good yield (∼69%) and high purity (>98%). In contrast to other sulfonylatio
Publikováno v:
ChemInform. 33
Autor:
Samantha Rutherford, Gary J. Tarver, Ming Qiang Zhang, Anton Bom, Kirsteen Buchanan, Grove Simon James Anthony, Andrew Cooke
Publikováno v:
Bioorganicmedicinal chemistry. 10(6)
A series of secondary face modified cyclodextrins (CDs) were synthesised with the aim of constructing host molecules capable of forming host–guest complexes with neuromuscular blockers, especially with rocuronium bromide. Perfacial 2- O -substituti
Autor:
Zhang Mingqiang, Alan W. Muir, Grove Simon James Anthony, Eleanor Pow, Jasmit Kaur, Gary J. Tarver
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(2)
A series of oxyanilinium-based AChE inhibitors have been synthesised and tested for the reversal of vecuronium-induced neuromuscular block. Several compounds, for example 2-hydroxy- and 2-methoxy-N,N-dimethyl-N-allylanilinium bromide (3 and 6) showed