Safety and feasibility of a tolerogenic dendritic cell-based treatment of multiple sclerosis (MS): a collaborative initiative comparing intranodal and intradermal cell administration in two phase I clinical trials

Autor: Willekens, B, Presas-Rodriguez, S, Mansilla, M, Derdelinckx, J, Lee, WP, Nijs, G, Laere, M, Wens, I, Cras, P, Parizel, PM, Hecke, W, Ribbens, A, Adams, G, Couttenye, M, Navarro-Barriuso, J, Teniente-Serra, A, Quirant-Sanchez, B, Verheij, H, Kip, A, de Cerio, AD, Inoges, S, Prosper, F, Gross, CC, Wiendl, H, Ham, S, Brinke, A, Barriocanal, A, Massuet-Vilamajo, A, Hens, N, Berneman, Z, Martinez-Caceres, E, Cools, N, Ramo-Tello, C

Publikováno v: MULTIPLE SCLEROSIS JOURNAL
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::c7ffe4b8ac38c219d52b90bbc9a0a8fc
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6275

Atlas of Cerebrospinal Fluid Immune Cells Across Neurological Diseases.

Autor: Heming M; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Börsch AL; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Melnik S; Institute of Medical Informatics, University of Münster, Münster, Germany., Gmahl N; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Müller-Miny L; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Dambietz C; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Fisch L; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Kühnel T; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Brix TJ; Institute of Medical Informatics, University of Münster, Münster, Germany., Janssen A; Institute of Medical Informatics, University of Münster, Münster, Germany., Schumann E; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Gross CC; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Varghese J; Institute of Medical Informatics, University of Münster, Münster, Germany., Hahn T; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Wiendl H; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany., Meyer Zu Hörste G; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.

Publikováno v: Annals of neurology [Ann Neurol] 2024 Dec 12. Date of Electronic Publication: 2024 Dec 12.

CSF and blood signatures support classification of limbic encephalitis subtypes.

Autor: Schulte-Mecklenbeck A; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany., Dik A; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany., Strippel C; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany; Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom., Bierhansl L; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany., Meyer N; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany., Korn L; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany., Pawlowski M; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany., Räuber S; Department of Neurology, Medical Faculty, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany., Alferink J; Department of Psychiatry, University of Münster, Germany., Meuth SG; Department of Neurology, Medical Faculty, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany., Melzer N; Department of Neurology, Medical Faculty, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany., Meyer Zu Hörste G; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany., Prüß H; Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, Germany., Wiendl H; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany., Gross CC; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany., Kovac S; Department of Neurology with Institute of Translational Neurology, University of Münster, Germany.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2025 Jan; Vol. 123, pp. 697-706. Date of Electronic Publication: 2024 Oct 12.

Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation.

Autor: Schneider-Hohendorf T; Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany., Wünsch C; Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany., Falk S; Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany., Raposo C; F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Rubelt F; Roche Sequencing Solutions, 4300 Pleasanton, CA, USA., Mirebrahim H; Roche Sequencing Solutions, 4300 Pleasanton, CA, USA., Asgharian H; Roche Sequencing Solutions, 4300 Pleasanton, CA, USA., Schlecht U; Roche Sequencing Solutions, 4300 Pleasanton, CA, USA., Mattox D; Adaptive Biotechnologies, 98109 Seattle, WA, USA., Zhou W; Adaptive Biotechnologies, 98109 Seattle, WA, USA., Dawin E; Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany., Pawlitzki M; Department of Neurology, Otto von Guericke University, 39106 Magdeburg, Germany.; Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany., Lauks S; Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany., Jarius S; Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany., Wildemann B; Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany., Havla J; Institute of Clinical Neuroimmunology, LMU Klinikum, Ludwig-Maximilians-Universiät München, 80539 München, Germany., Kümpfel T; Institute of Clinical Neuroimmunology, LMU Klinikum, Ludwig-Maximilians-Universiät München, 80539 München, Germany., Schrot MC; Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany., Ringelstein M; Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.; Department of Neurology, LVR-Klinikum, Heinrich-Heine-University Düsseldorf, 40629 Düsseldorf, Germany., Kraemer M; Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.; Department of Neurology, Alfried Krupp Hospital, 45131 Essen, Germany., Schwake C; Department of Neurology, St. Josef Hospital, Ruhr University Bochum, 44791 Bochum, Germany., Schmitter T; Department of Neurology, St. Josef Hospital, Ruhr University Bochum, 44791 Bochum, Germany., Ayzenberg I; Department of Neurology, St. Josef Hospital, Ruhr University Bochum, 44791 Bochum, Germany., Fischer K; Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany., Meuth SG; Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany., Aktas O; Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany., Hümmert MW; Department of Neurology, Hannover Medical School, 30625 Hannover, Germany., Kretschmer JR; Department of Neurology, Hannover Medical School, 30625 Hannover, Germany., Trebst C; Department of Neurology, Hannover Medical School, 30625 Hannover, Germany., Kleffner I; Department of Neurology, Knappschaftskrankenhaus, Ruhr University Bochum, 44892 Bochum, Germany., Massey J; Department of Neurology, St Vincent's Hospital, 2010 Sydney, Australia., Muraro PA; Department of Brain Sciences, Imperial College London, W12 0NN London, UK., Chen-Harris H; Adaptive Biotechnologies, 98109 Seattle, WA, USA., Gross CC; Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany., Klotz L; Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany., Wiendl H; Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany., Schwab N; Department of Neurology with Institute of Translational Neurology, University of Muenster, 48149 Muenster, Germany.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Jul 18. Date of Electronic Publication: 2024 Jul 18.

Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories.

Autor: Gross CC; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Schulte-Mecklenbeck A; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Steinberg OV; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Wirth T; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Lauks S; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Bittner S; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany., Schindler P; Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany., Baranzini SE; Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA., Groppa S; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany., Bellmann-Strobl J; Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Bünger N; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Chien C; Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; NeuroCure Clinical Research Center, Charité - Univeritäsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany., Dawin E; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Eveslage M; Institute of Biostatistics and Clinical Research, University of Münster, 48149 Münster, Germany., Fleischer V; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany., Gonzalez-Escamilla G; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany., Gisevius B; Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791 Bochum, Germany., Haas J; Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany., Kerschensteiner M; Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center (BMC), Faculty of Medicine, Ludwig Maximilians University of Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Kirstein L; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Korsukewitz C; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Lohmann L; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Lünemann JD; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Luessi F; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany., Meyer Zu Hörste G; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Motte J; Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791 Bochum, Germany., Ruck T; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany., Ruprecht K; Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany., Schwab N; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Steffen F; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany., Meuth SG; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany.; Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany., Paul F; Experimental and Clinical Research Center, a Cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany., Wildemann B; Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany., Kümpfel T; Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center (BMC), Faculty of Medicine, Ludwig Maximilians University of Munich, 81377 Munich, Germany., Gold R; Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791 Bochum, Germany., Hahn T; Institute for Translational Psychiatry, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Zipp F; Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany., Klotz L; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany., Wiendl H; Department of Neurology with Institute of Translational Neurology, University Hospital of Münster, University of Münster, 48149 Münster, Germany.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Mar 27; Vol. 16 (740), pp. eade8560. Date of Electronic Publication: 2024 Mar 27.