Apoptotic cell fragments locally activate tingible body macrophages in the germinal center

Autor: Grootveld, AK, Kyaw, W, Panova, V, Lau, AWY, Ashwin, E, Seuzaret, G, Dhenni, R, Bhattacharyya, ND, Khoo, WH, Biro, M, Mitra, T, Meyer-Hermann, M, Bertolino, P, Tanaka, M, Hume, DA, Croucher, PI, Brink, R, Nguyen, A, Bannard, O, Phan, TG

Publikováno v: Cell. 186:1144-1161.e18

Germinal centers (GCs) that form within lymphoid follicles during antibody responses are sites of massive cell death. Tingible body macrophages (TBMs) are tasked with apoptotic cell clearance to prevent secondary necrosis and autoimmune activation by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e8ece1063f6f8b6d2b7585ea489387
https://doi.org/10.1016/j.cell.2023.02.004

Invasion-Block and S-MARVEL: A high-content screening and image analysis platform identifies ATM kinase as a modulator of melanoma invasion and metastasis.

Autor: Guo D; Immune Imaging Program, Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.; Sydney Medical School, The University of Sydney, Camperdown, NSW 2050, Australia., Jurek R; Australia Telescope National Facility, The Commonwealth Scientific and Industrial Research Organisation (CSIRO) Astronomy and Space Science, Australia Telescope National Facility, Marsfield NSW 2122, Australia., Beaumont KA; Immune Imaging Program, Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.; Sydney Medical School, The University of Sydney, Camperdown, NSW 2050, Australia., Sharp DS; Immune Imaging Program, Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia., Tan SY; Immune Imaging Program, Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia., Mariana A; The Australian Cancer Research Foundation (ACRF) Drug Discovery Centre for Childhood Cancer, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales (UNSW) Sydney, Sydney, NSW 2052, Australia., Failes TW; The Australian Cancer Research Foundation (ACRF) Drug Discovery Centre for Childhood Cancer, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales (UNSW) Sydney, Sydney, NSW 2052, Australia.; School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales (UNSW) Sydney, Sydney, NSW 2052, Australia., Grootveld AK; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.; St Vincent's Healthcare Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW 2010, Australia., Bhattacharyya ND; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.; St Vincent's Healthcare Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW 2010, Australia., Phan TG; Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.; St Vincent's Healthcare Clinical Campus, School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW 2010, Australia., Arndt GM; The Australian Cancer Research Foundation (ACRF) Drug Discovery Centre for Childhood Cancer, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales (UNSW) Sydney, Sydney, NSW 2052, Australia.; School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales (UNSW) Sydney, Sydney, NSW 2052, Australia., Jain R; Immune Imaging Program, Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.; Sydney Medical School, The University of Sydney, Camperdown, NSW 2050, Australia.; Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria., Weninger W; Immune Imaging Program, Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.; Sydney Medical School, The University of Sydney, Camperdown, NSW 2050, Australia.; Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria., Tikoo S; Immune Imaging Program, Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia.; Sydney Medical School, The University of Sydney, Camperdown, NSW 2050, Australia.; Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Nov 21; Vol. 120 (47), pp. e2303978120. Date of Electronic Publication: 2023 Nov 14.

Subcapsular Sinus Macrophages: The Seat of Innate and Adaptive Memory in Murine Lymph Nodes.

Autor: Moran I; Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia. Electronic address: i.moran@garvan.org.au., Grootveld AK; Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; Department of Biology and Biochemistry, Faculty of Science, University of Bath, Bath, UK., Nguyen A; Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia., Phan TG; Immunology Division, Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia. Electronic address: t.phan@garvan.org.au.

Publikováno v: Trends in immunology [Trends Immunol] 2019 Jan; Vol. 40 (1), pp. 35-48. Date of Electronic Publication: 2018 Nov 27.