Zobrazeno 1 - 10 of 110 pro vyhledávání: '"Groothuis GMM"'
1
Cellular distribution and handling of liver-targeting preparations in human livers studied by a liver lobe perfusion
Autor: Melgert, BN, Olinga, P, Weert, B, Slooff, MJH, Meijer, DKF, Poelstra, K, Groothuis, GMM
Publikováno v: Drug Metabolism and Disposition, 29(4), 361-367. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
We developed and tested a novel method for perfusing parts of human liver to study uptake and handling of drug-targeting preparations. These preparations, designed for the treatment of liver fibrosis in man, have been extensively studied in animals,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cac5731d6f7d178bed3e1f7e3c82277a
https://research.rug.nl/en/publications/0c73791c-5084-410b-b686-22e645315e06
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2
The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake
Autor: Olinga, P, Hof, IH, Smit, M, de Jager, MH, Swart, PJ, Slooff, MJH, Meijer, DKF, Groothuis, GMM, Merema, M.T.
Publikováno v: Journal of Pharmacological and Toxicological Methods, 45(1), 55-63
In the present study we investigated the applicability of the liver slice model to study mechanisms of drug uptake. Four model compounds were investigated that enter hepatocytes via entirely different membrane transport mechanisms. Rhodamine B (RB),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::dc7560045ec96c12ecc4ac89d72e0b6b
https://research.rug.nl/en/publications/a0d631ab-1b09-4573-a3cb-054934919e61
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3
The capability of isolated hepatocytes and liver slices of donor livers to predict graft function after liver transplantation
Autor: Olinga, P, Maring, JK, Hof, IH, Slooff, MJH, Meijer, DKF, Groothuis, GMM, Merema, M.T.
Publikováno v: Liver, 20(5), 374-380
Aims/Background: In liver transplantation, adequate function tests for donor livers and transplanted livers are of utmost importance to provide an objective basis for decision-making. Isolated hepatocyte and/or slice preparations from human donor liv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::732f3b4a3745a4685f04e8cc59b958bf
https://research.rug.nl/en/publications/dfd08fdf-79e4-482b-81d8-40e4b7cd5f6e
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4
Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women
Autor: Verhoeven, CHJ, Gloudemans, RHM, Groothuis, GMM, Rietjens, IMCM, Vos, RME
Publikováno v: Journal of steroid biochemistry and molecular biology, 73(1-2), 39-48. PERGAMON-ELSEVIER SCIENCE LTD
Metabolism of Org 30659 ((17 alpha)-17-hydroxy-11-methylene-19-norpregna-4,15-dien-20-yn-3-one), a new potent progestagen currently under clinical development by NV Organon for use in oral contraception and hormone replacement therapy was studied in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::db06f5ffa0df8d0a2b5997a476a392f0
https://research.rug.nl/en/publications/099d45ee-a026-4563-8860-41950c32a973
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5
In vitro and in vivo metabolism of the progestagen Org 30659 in several species
Autor: Verhoeven, CHJ, Krebbers, SFM, Wagenaars, GN, Bogy, CJ, Groothuis, GMM, Olinga, P, Vos, RME
Publikováno v: Drug Metabolism and Disposition, 26(11), 1102-1112. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
The metabolism of Org 30659 [(17 alpha)-17-hydroxy-11-methylene-19-norpregna-4,15-dien-20-yn-3-one], a new potent progestagen currently under clinical development by NV Organon for use in oral contraceptive and hormone replacement therapy, was studie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::f9a8d92b5930b00bb31250d3cc22a804
https://research.rug.nl/en/publications/4cc66143-d269-42fb-96ba-ff3fff173573
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6
METABOLISM OF 3 PHARMACOLOGICALLY ACTIVE-DRUGS IN ISOLATED HUMAN AND RAT HEPATOCYTES - ANALYSIS OF INTERSPECIES VARIABILITY AND COMPARISON WITH METABOLISM IN-VIVO
Autor: SANDKER, GW, VOS, RME, DELBRESSINE, LPC, SLOOFF, MJH, MEIJER, DKF, GROOTHUIS, GMM
Publikováno v: Xenobiotica, 24(2), 143-155
1. The metabolism of the three drugs (Org GB 94, Org 3770 and Org OD 14) was studied in isolated human and rat hepatocytes. The metabolic profiles in rat and human hepatocytes were compared with the available in vivo data in both species. 2. All thre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::f341ab293421c92c93e5bf19d2cbe33c
https://research.rug.nl/en/publications/db282efa-a08a-4c67-aa67-d97bab0080af
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7
USE OF HUMAN LIVER SLICES AND HEPATOCYTES IN METABOLISM
Autor: OLINGA, P, MEIJER, DKF, SLOOFF, MJH, GROOTHUIS, GMM, Merema, M.T., Crommelin, D, Couvreur, P, Duchene, D
Publikováno v: IN VITRO AND EX VIVO TEST SYSTEMS TO RATIONALIZE DRUG DESIGN AND DELIVERY, 204-208
STARTPAGE=204;ENDPAGE=208;TITLE=IN VITRO AND EX VIVO TEST SYSTEMS TO RATIONALIZE DRUG DESIGN AND DELIVERY
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::37f40e10d9cb3aa6ce54a2531ebf2558
https://research.rug.nl/en/publications/d7e1c6b4-62e6-4ce5-b574-5d151a3775cc
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8
THE ISOLATED-PERFUSED RAT-LIVER AS A TOOL TO STUDY DRUG TRANSPORT, DRUG-METABOLISM AND CELL-SPECIFIC DRUG-DELIVERY
Autor: MEIJER, DKF, GROOTHUIS, GMM, SWART, PJ, Crommelin, D, Couvreur, P, Duchene, D
Publikováno v: IN VITRO AND EX VIVO TEST SYSTEMS TO RATIONALIZE DRUG DESIGN AND DELIVERY, 17-31
STARTPAGE=17;ENDPAGE=31;TITLE=IN VITRO AND EX VIVO TEST SYSTEMS TO RATIONALIZE DRUG DESIGN AND DELIVERY
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::bb7098db52a2d3505769c72f82804d7e
https://research.rug.nl/en/publications/cfef88f5-1be5-42b7-a91e-f8209ca51765
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9
HUMAN HEPATOCYTES AS A TOOL TO STUDY HEPATIC DRUG TRANSPORT IN MAN
Autor: GROOTHUIS, GMM, OLINGA, P, SANDKER, GW, SLOOFF, MJH, MEIJER, DKF, Merema, M.T., Crommelin, D, Couvreur, P, Duchene, D
Publikováno v: IN VITRO AND EX VIVO TEST SYSTEMS TO RATIONALIZE DRUG DESIGN AND DELIVERY, 199-203
STARTPAGE=199;ENDPAGE=203;TITLE=IN VITRO AND EX VIVO TEST SYSTEMS TO RATIONALIZE DRUG DESIGN AND DELIVERY
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cdad9236dfe5b060de2e3d705057f201
https://research.rug.nl/en/publications/6ecad859-d135-4c93-81cd-27f9906d9e3f
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10
MAINTENANCE OF VIABILITY AND TRANSPORT FUNCTION AFTER PRESERVATION OF ISOLATED RAT HEPATOCYTES IN VARIOUS SIMPLIFIED UNIVERSITY-OF-WISCONSIN SOLUTIONS
Autor: SANDKER, GW, WEERT, B, KUIPERS, W, SLOOFF, MJH, MEIJER, DKF, GROOTHUIS, GMM, Merema, M.T.
Publikováno v: Biochemical Pharmacology, 46(11), 2093-2096. PERGAMON-ELSEVIER SCIENCE LTD
Rat hepatocytes were preserved for 24hr with high recovery and good maintenance of viability and transport function both in University of Wisconsin (UW) solution and in various simplified UW solutions. Cell quality is somewhat affected after 48 hr of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::ac1173b78e7201540afc49e9d31b1bcf
https://research.rug.nl/en/publications/2e8c08cf-4c99-4953-8608-29a81c7288b3
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