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Targeting oxidative stress for the treatment of liver fibrosis

Autor: Luangmonkong, Theerut, Suriguga, Su, Mutsaers, Henricus A. M., Groothuis, Geny M. M., Olinga, Peter, Boersema, Miriam, Nilius, B, DeTombe, P, Gudermann, T, Jahn, R, Lill, R

Publikováno v: Luangmonkong, T, Suriguga, S, Mutsaers, H A M, Groothuis, G M M, Olinga, P & Boersema, M 2018, Targeting oxidative stress for the treatment of liver fibrosis . in Reviews of Physiology, Biochemistry and Pharmacology . Springer, Reviews of Physiology, Biochemistry and Pharmacology, vol. 175, pp. 71-102 . https://doi.org/10.1007/112_2018_10
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175 ISBN: 9783319952871
Reviews of Physiology, Biochemistry and Pharmacology, 71-102
STARTPAGE=71;ENDPAGE=102;TITLE=Reviews of Physiology, Biochemistry and Pharmacology

Oxidative stress is a reflection of the imbalance between the production of reactive oxygen species (ROS) and the scavenging capacity of the antioxidant system. Excessive ROS, generated from various endogenous oxidative biochemical enzymes, interfere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a9023145c262a8ea296f598570f272
https://pure.au.dk/portal/da/publications/targeting-oxidative-stress-for-the-treatment-of-liver-fibrosis(253448b5-6001-4677-96df-e376e1b12371).html

P-gp activity and inhibition in the different regions of human intestine ex vivo

Autor: Li, Ming, de Graaf, Inge A M, de Jager, Marina H, Groothuis, Geny M M

Publikováno v: Biopharmaceutics & drug disposition, 38(2), 127-138

Although intestinal P-glycoprotein (P-gp) has been extensively studied in vitro and in animals, its activity and the consequences of P-gp inhibition for drug disposition and toxicity in humans are still difficult to accurately extrapolate from these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a5ad4887924c036f934d728e0a672e47
https://research.rug.nl/en/publications/c815da65-2804-4138-89f2-35d39db68f06

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