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Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe-5S Cluster for Sulfur Insertion.

Autor: Lachowicz JC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Lennox-Hvenekilde D; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, 2800, Denmark.; Biosyntia ApS, Copenhagen, 2100, Denmark., Myling-Petersen N; Biosyntia ApS, Copenhagen, 2100, Denmark., Salomonsen B; Biosyntia ApS, Copenhagen, 2100, Denmark., Verkleij G; Biosyntia ApS, Copenhagen, 2100, Denmark., Acevedo-Rocha CG; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, 2800, Denmark.; Biosyntia ApS, Copenhagen, 2100, Denmark., Caddell B; Biosyntia ApS, Copenhagen, 2100, Denmark., Gronenberg LS; Biosyntia ApS, Copenhagen, 2100, Denmark., Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Sommer MOA; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, 2800, Denmark., Genee HJ; Biosyntia ApS, Copenhagen, 2100, Denmark., Grove TL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Jan 24; Vol. 146 (3), pp. 1860-1873. Date of Electronic Publication: 2024 Jan 12.

Improved biotin, thiamine, and lipoic acid biosynthesis by engineering the global regulator IscR.

Autor: Bali AP; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark; Biosyntia ApS, Fruebjergvej 3, Copenhagen E, 2100, Denmark., Lennox-Hvenekilde D; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark; Biosyntia ApS, Fruebjergvej 3, Copenhagen E, 2100, Denmark., Myling-Petersen N; Biosyntia ApS, Fruebjergvej 3, Copenhagen E, 2100, Denmark., Buerger J; Biosyntia ApS, Fruebjergvej 3, Copenhagen E, 2100, Denmark., Salomonsen B; Biosyntia ApS, Fruebjergvej 3, Copenhagen E, 2100, Denmark., Gronenberg LS; Biosyntia ApS, Fruebjergvej 3, Copenhagen E, 2100, Denmark., Sommer MOA; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark., Genee HJ; Biosyntia ApS, Fruebjergvej 3, Copenhagen E, 2100, Denmark. Electronic address: hjg@biosyntia.com.

Publikováno v: Metabolic engineering [Metab Eng] 2020 Jul; Vol. 60, pp. 97-109. Date of Electronic Publication: 2020 Mar 25.

Microbial cell factories for the sustainable manufacturing of B vitamins.

Autor: Acevedo-Rocha CG; Biosyntia Aps, 2100 Copenhagen, Denmark., Gronenberg LS; Biosyntia Aps, 2100 Copenhagen, Denmark., Mack M; Institute for Technical Microbiology, Mannheim University of Applied Sciences, 68163 Mannheim, Germany., Commichau FM; Department of General Microbiology, University of Göttingen, 37077 Göttingen, Germany., Genee HJ; Biosyntia Aps, 2100 Copenhagen, Denmark. Electronic address: hjg@biosyntia.com.

Publikováno v: Current opinion in biotechnology [Curr Opin Biotechnol] 2019 Apr; Vol. 56, pp. 18-29. Date of Electronic Publication: 2018 Aug 20.

Characterization of a stalled complex on the β-barrel assembly machine.

Autor: Lee J; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138;, Xue M; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138;, Wzorek JS; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138;, Wu T; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138;, Grabowicz M; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544;, Gronenberg LS; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138;, Sutterlin HA; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544;, Davis RM; Department of Microbiology, The Ohio State University, Columbus, OH 43210;, Ruiz N; Department of Microbiology, The Ohio State University, Columbus, OH 43210; ruiz.82@osu.edu tsilhavy@princeton.edu kahne@chemistry.harvard.edu., Silhavy TJ; Department of Molecular Biology, Princeton University, Princeton, NJ, 08544; ruiz.82@osu.edu tsilhavy@princeton.edu kahne@chemistry.harvard.edu., Kahne DE; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 ruiz.82@osu.edu tsilhavy@princeton.edu kahne@chemistry.harvard.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Aug 02; Vol. 113 (31), pp. 8717-22. Date of Electronic Publication: 2016 Jul 20.