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New Spirocyclic Hydroxamic Acids as Effective Antiproliferative Agents.

Autor: Neganova ME; Institute of Physiologically Active Compounds of Russian Academy of Sciences, Severny pr, 1. Chernogolovka, Moscow Region, 142432, Russian Federation., Klochkov SG; Institute of Physiologically Active Compounds of Russian Academy of Sciences, Severny pr, 1. Chernogolovka, Moscow Region, 142432, Russian Federation., Aleksandrova YR; Institute of Physiologically Active Compounds of Russian Academy of Sciences, Severny pr, 1. Chernogolovka, Moscow Region, 142432, Russian Federation., Osipov VN; N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation, Kashirskoe sh., 23, Moscow, 115478, Russian Federation., Avdeev DV; National Medical Research Center of Cardiology of the Ministry of Health of the Russian Federation, Street 3-ja Cherepkovskaja 15A, Moscow, 121552, Russian Federation., Pukhov SA; Institute of Physiologically Active Compounds of Russian Academy of Sciences, Severny pr, 1. Chernogolovka, Moscow Region, 142432, Russian Federation., Gromyko AV; JSC Pharm-Sintez, Vereyskaya Str., 29, bld. 134, Moscow, 121357, Russian Federation., Aliev G; Institute of Physiologically Active Compounds of Russian Academy of Sciences, Severny pr, 1. Chernogolovka, Moscow Region, 142432, Russian Federation.

Publikováno v: Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2021; Vol. 21 (5), pp. 597-610.

Dimeric bisbenzimidazoles inhibit the DNA methylation catalyzed by the murine Dnmt3a catalytic domain.

Autor: Cherepanova NA; Chemistry Department, Moscow State University, Moscow, Russian Federation., Ivanov AA, Maltseva DV, Minero AS, Gromyko AV, Streltsov SA, Zhuze AL, Gromova ES

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2011 Apr; Vol. 26 (2), pp. 295-300. Date of Electronic Publication: 2010 Jul 08.

Minor groove dimeric bisbenzimidazoles inhibit in vitro DNA binding to eukaryotic DNA topoisomerase I.

Autor: Susova OY; Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. susovaolga@gmail.com, Ivanov AA, Morales Ruiz SS, Lesovaya EA, Gromyko AV, Streltsov SA, Zhuze AL

Publikováno v: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2010 Jun; Vol. 75 (6), pp. 695-701.

The Hoechst 33258 covalent dimer covers a total turn of the double-stranded DNA.

Autor: Streltsov SA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow 119991, Russia. strelcov@eimb.ru, Gromyko AV, Oleinikov VA, Zhuze AL

Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2006 Dec; Vol. 24 (3), pp. 285-302.