Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophages

Autor: Kim, Yongeun, Gromovsky, Anthony D., Brown, J. Mark, Chung, Soonkyu

Publikováno v: In The Journal of Nutritional Biochemistry August 2018 58:169-177

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches.

Autor: Shakya, Sajina¹ (AUTHOR), Gromovsky, Anthony D.² (AUTHOR), Hale, James S.^2,3 (AUTHOR), Knudsen, Arnon M.^4,5 (AUTHOR), Prager, Briana^6,7 (AUTHOR), Wallace, Lisa C.¹ (AUTHOR), Penalva, Luiz O. F.⁸ (AUTHOR), Brown, H. Alex⁹ (AUTHOR), Kristensen, Bjarne W.^4,5 (AUTHOR), Rich, Jeremy N.¹⁰ (AUTHOR), Lathia, Justin D.^2,3,6 (AUTHOR), Brown, J. Mark^2,3,6 (AUTHOR), Hubert, Christopher G.^1,3,6 (AUTHOR) hubertc@ccf.org

Publikováno v: Acta Neuropathologica Communications. 5/31/2021, Vol. 9 Issue 1, p1-18. 18p.

TAMI-18. DIFFERENTIAL LIPID METABOLISM IN CANCER MICROENVIRONMENTS LEADS TO A REQUIREMENT FOR FATTY ACID DESATURASES FADS1 AND FADS2 IN GBM CANCER STEM CELL MAINTENANCE

Autor: Shakya, Sajina, Gromovsky, Anthony D., Hale, James S, Møldrup Knudsen, Arnon, Prager, Briana, Wallace, Lisa C., Penalva, Luiz O.F., Brown, H. Alex, Kristensen, Bjarne, Rich, Jeremy N, Lathia, Justin D, Brown, Jonathan Mark, Hubert, Christopher G

Publikováno v: Neuro Oncol
Shakya, S, Gromovsky, A D, Hale, J S, Møldrup Knudsen, A, Prager, B, Wallace, L C, Penalva, L O F, Brown, H A, Kristensen, B, Rich, J N, Lathia, J D, Brown, J M & Hubert, C G 2021, ' TAMI-18. Differential lipid metabolism in cancer microenvironments leads to a requirement for fatty acid desaturases FAD1 and FAD2 in GBM cancer stem cell maintenance ', Neuro-Oncology, vol. 23, no. Suppl. 6, pp. vi201-vi202 . https://doi.org/10.1093/neuonc/noab196.802

Glioblastoma (GBM) is marked by cellular heterogeneity through microenvironments of a tumor, including metabolic heterogeneity. While altered cellular metabolism in cancer is well-known, how lipid metabolism is altered in different GBM microenvironme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71580b773dfae7c7ca9cfae368417a97
https://doi.org/10.1093/neuonc/noab196.802

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The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Autor: Schugar, Rebecca C., Shih, Diana M., Warrier, Manya, Helsley, Robert N., Burrows, Amy, Ferguson, Daniel, Brown, Amanda L., Gromovsky, Anthony D., Heine, Markus, Chatterjee, Arunachal, Li, Lin, Li, Xinmin S., Wang, Zeneng, Willard, Belinda, Meng, YongHong, Kim, Hanjun, Che, Nam, Pan, Calvin, Lee, Richard G., Crooke, Rosanne M., Graham, Mark J., Morton, Richard E., Langefeld, Carl D., Das, Swapan K., Rudel, Lawrence L., Zein, Nizar, McCullough, Arthur J., Dasarathy, Srinivasan, Tang, W.H. Wilson, Erokwu, Bernadette O., Flask, Chris A., Laakso, Markku, Civelek, Mete, Naga Prasad, Sathyamangla V., Heeren, Joerg, Lusis, Aldons J., Hazen, Stanley L., Brown, J. Mark

Publikováno v: In Cell Reports 20 June 2017 19(12):2451-2461