Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Gromoslaw A. Smolen"'
Autor:
Igor Dolgalev, Hua Zhou, Nina Murrell, Hortense Le, Theodore Sakellaropoulos, Nicolas Coudray, Kelsey Zhu, Varshini Vasudevaraja, Anna Yeaton, Chandra Goparaju, Yonghua Li, Imran Sulaiman, Jun-Chieh J. Tsay, Peter Meyn, Hussein Mohamed, Iris Sydney, Tomoe Shiomi, Sitharam Ramaswami, Navneet Narula, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Wei-Yi Cheng, James Cai, Salman Punekar, Vamsidhar Velcheti, Daniel H. Sterman, J. T. Poirier, Ben Neel, Kwok-Kin Wong, Luis Chiriboga, Adriana Heguy, Thales Papagiannakopoulos, Bettina Nadorp, Matija Snuderl, Leopoldo N. Segal, Andre L. Moreira, Harvey I. Pass, Aristotelis Tsirigos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Approximately 30% of early-stage lung adenocarcinoma patients present with disease progression after successful surgical resection. Despite efforts of mapping the genetic landscape, there has been limited success in discovering predictive bi
Externí odkaz:
https://doaj.org/article/326ae301e3024de2b6652801e0ebede8
Autor:
Kristiaan J. Lenos, Sander Bach, Leandro Ferreira Moreno, Sanne ten Hoorn, Nina R. Sluiter, Sanne Bootsma, Felipe A. Vieira Braga, Lisanne E. Nijman, Tom van den Bosch, Daniel M. Miedema, Erik van Dijk, Bauke Ylstra, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Robert R. J. Coebergh van den Braak, Jan N. M. IJzermans, John W. M. Martens, Sally Hallam, Andrew D. Beggs, Geert J. P. L. Kops, Nico Lansu, Vivian P. Bastiaenen, Charlotte E. L. Klaver, Maria C. Lecca, Khalid El Makrini, Clara C. Elbers, Mark P. G. Dings, Carel J. M. van Noesel, Onno Kranenburg, Jan Paul Medema, Jan Koster, Lianne Koens, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. de Hingh, Maarten F. Bijlsma, Jurriaan B. Tuynman, Louis Vermeulen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases from 52 patients using RNA-seq and mutational sequencing and show a distinct
Externí odkaz:
https://doaj.org/article/369abe186b03465f8bac79e90a4d4606
Autor:
Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol bios
Externí odkaz:
https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
Autor:
Anil K. Padyana, Stefan Gross, Lei Jin, Giovanni Cianchetta, Rohini Narayanaswamy, Feng Wang, Rui Wang, Cheng Fang, Xiaobing Lv, Scott A. Biller, Lenny Dang, Christopher E. Mahoney, Nelamangala Nagaraja, David Pirman, Zhihua Sui, Janeta Popovici-Muller, Gromoslaw A. Smolen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and is a target for hypercholesteremia and cancer drug development. Here the authors present the crystal structures of the human SQLE catalytic domain alone and bound with small mo
Externí odkaz:
https://doaj.org/article/13114a6254b94cd5a8f05eeabf842c50
Autor:
Eric L. Allen, Danielle B. Ulanet, David Pirman, Christopher E. Mahoney, John Coco, Yaguang Si, Ying Chen, Lingling Huang, Jinmin Ren, Sung Choe, Michelle F. Clasquin, Erin Artin, Zi Peng Fan, Giovanni Cianchetta, Joshua Murtie, Marion Dorsch, Shengfang Jin, Gromoslaw A. Smolen
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 876-890 (2016)
Although aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained challenging. Here, we conducted an siRNA screen focusing on enzymes involved in the tricarboxy
Externí odkaz:
https://doaj.org/article/038a8ba083f6473f859242fde11df665
Autor:
Sarah Javaid, Jianmin Zhang, Endre Anderssen, Josh C. Black, Ben S. Wittner, Ken Tajima, David T. Ting, Gromoslaw A. Smolen, Matthew Zubrowski, Rushil Desai, Shyamala Maheswaran, Sridhar Ramaswamy, Johnathan R. Whetstine, Daniel A. Haber
Publikováno v:
Cell Reports, Vol 5, Iss 6, Pp 1679-1689 (2013)
Epithelial-mesenchymal transition (EMT) is thought to contribute to cancer metastasis, but its underlying mechanisms are not well understood. To define early steps in this cellular transformation, we analyzed human mammary epithelial cells with tight
Externí odkaz:
https://doaj.org/article/7588eecd7f8a4c04a2e31ffb74fb0d5f
Autor:
Daniel A. Haber, Sridhar Ramaswamy, Toshi Shioda, Shyamala Maheswaran, Mehmet Toner, Shannon L. Stott, David T. Ting, Benjamin J. Schott, Matthew J. Zubrowski, Rushil Desai, Marissa W. Madden, Kshitij S. Arora, Anurag Singh, Ben S. Wittner, Min Yu, Gromoslaw A. Smolen, Jianmin Zhang, Sarah Javaid
Figure S3. Illustration of modeling and correcting for dependence of each marker through the expression level of housekeeping genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5357c9d8303f4f29e9adba225b6f61b6
https://doi.org/10.1158/1541-7786.22514362.v1
https://doi.org/10.1158/1541-7786.22514362.v1
Autor:
Daniel A. Haber, Sridhar Ramaswamy, Toshi Shioda, Shyamala Maheswaran, Mehmet Toner, Shannon L. Stott, David T. Ting, Benjamin J. Schott, Matthew J. Zubrowski, Rushil Desai, Marissa W. Madden, Kshitij S. Arora, Anurag Singh, Ben S. Wittner, Min Yu, Gromoslaw A. Smolen, Jianmin Zhang, Sarah Javaid
Supplemental Methods, Tables S1-2, Table Legends and Figure Legends Table S1.List of qRT-PCR primers used for epithelial, mesenchymal, inducer and housekeeping genes. Table S2. RNA-ISH quantitation of expression scores used in Figure 5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22887371ebfa2af8a23b3f857386492d
https://doi.org/10.1158/1541-7786.22514341.v1
https://doi.org/10.1158/1541-7786.22514341.v1
Supplementary Table 1 from Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the Drosophila Hippo Pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1933a788205b8655968d21cd9710149b
https://doi.org/10.1158/0008-5472.22375569.v1
https://doi.org/10.1158/0008-5472.22375569.v1
Autor:
Daniel A. Haber, Chu-Xia Deng, Lynda Chin, Dennis C. Sgroi, Daphne W. Bell, Judy E. Garber, Sonika Dahiya, Eunice Kwak, Ross A. Okimoto, Sara M. Haserlat, Miguel N. Rivera, Woo J. Kim, Anne Barmettler, Gayatry Mohapatra, Beth Muir, Gromoslaw A. Smolen
In a screen for gene copy number alterations in mouse mammary tumors initiated by loss of the Brca1 and Trp53 genes, we observed that the majority (11 of 15; 73%) had high-level amplification of wild-type Met, encoding a growth factor receptor implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7665f885a4ee24f319ccedd54295d1d7
https://doi.org/10.1158/0008-5472.c.6495387.v1
https://doi.org/10.1158/0008-5472.c.6495387.v1