Hypoxia-induced SETX links replication stress with the unfolded protein response

Autor: Ramachandran, S., Ma, T.S., Griffin, J., Ng, N., Foskolou, I.P., Hwang, M-S., Victori, P., Cheng, W-C., Buffa, F.M., Leszczynska, K.B., El-Khamisy, Sherif, Gromak, N., Hammond, E.M.

Yes
Tumour hypoxia is associated with poor patient prognosis and therapy resistance. A unique transcriptional response is initiated by hypoxia which includes the rapid activation of numerous transcription factors in a background of reduced globa

Externí odkaz: http://hdl.handle.net/10454/19700

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation

Autor: Cristini, A, Tellier, M, Constantinescu, F, Accalai, C, Albulescu, LO, Heiringhoff, R, Bery, N, Sordet, O, Murphy, S, Gromak, N

Publikováno v: Nature Communications. 13

RNase H2 is a specialized enzyme that degrades RNA in RNA/DNA hybrids and deficiency of this enzyme causes a severe neuroinflammatory disease, Aicardi Goutières syndrome (AGS). However, the molecular mechanism underlying AGS is still unclear. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6302f78f62eb9255d35730464e3073
https://doi.org/10.1038/s41467-022-30604-0

Transcription-dependent DNA double-strand breaks and human disease

Autor: Cristini, A, Gromak, N, Sordet, O

Publikováno v: Molecular & Cellular Oncology

Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs aris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::01127bb2a71c08773222c57362937f21
https://doi.org/10.1080/23723556.2019.1691905

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Primary microRNA transcripts are processed co-transcriptionally

Autor: Morlando, Mariangela, Ballarino, Monica, Gromak, N, Pagano, Francesca, Bozzoni, Irene, Proudfoot, Nj

Publikováno v: Scopus-Elsevier
CIÊNCIAVITAE
Nature structural biology (2008).
info:cnr-pdr/source/autori:Morlando M., Ballarino M., Gromak N., Pagano F., Bozzoni I. and Proudfoot N./titolo:Primary microRNA transcripts are processed co-transcriptionally,/doi:/rivista:Nature structural biology/anno:2008/pagina_da:/pagina_a:/intervallo_pagine:/volume

MicroRNAs are processed by Drosha, and previous data had suggested that this occurred soon after transcription. Following Drosha recruitment and using nuclear run-on technology, data now indicate that miRNAs both within and outside of introns are pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4935fba7db48387cd5a343c05f200d
https://doi.org/10.1038/nsmb.1475