Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer.

Autor: Travelli C; Department of Drug Sciences, Università degli Studi di Pavia, Pavia, Italy., Colombo G; Department of Pharmaceutical Science, University of Eastern Piedmont, Novara, Italy., Aliotta M; Department of Drug Sciences, Università degli Studi di Pavia, Pavia, Italy., Fagiani F; Department of Drug Sciences, Università degli Studi di Pavia, Pavia, Italy., Fava N; Department of Drug Sciences, Università degli Studi di Pavia, Pavia, Italy., De Sanctis R; Department of Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy., Grolla AA; Department of Pharmaceutical Science, University of Eastern Piedmont, Novara, Italy., Garcia JGN; Department of Medicine, University of Arizona Health Sciences, Tucson, Arizona, USA., Clemente N; Dipartimento di Scienze della Salute, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, Università del Piemonte Orientale, Novara, Italy., Portararo P; Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Costanza M; Department of Clinical Neuroscience, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy., Condorelli F; Department of Pharmaceutical Science, University of Eastern Piedmont, Novara, Italy., Colombo MP; Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Sangaletti S; Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Genazzani AA; Department of Pharmaceutical Science, University of Eastern Piedmont, Novara, Italy armando.genazzani@uniupo.it.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2023 Oct; Vol. 11 (10).

Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer's disease mouse model: a role for ER-mitochondria interaction.

Autor: Tapella L; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Dematteis G; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Moro M; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Pistolato B; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Tonelli E; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Vanella VV; Department of Translational Medicine, Center for Translational Research on Autoimmune and Allergic Diseases (CAAD), Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Giustina D; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., La Forgia A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Restelli E; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, via Mario Negri 2, 20156, Milan, Italy.; Human Technopole, Milan, Italy., Barberis E; Department of Translational Medicine, Center for Translational Research on Autoimmune and Allergic Diseases (CAAD), Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Cali T; Department of Biomedical Sciences, Neuroscience Center (PNC), Centro Studi per la Neurodegenerazione (CESNE), University of Padua, Padua, Italy., Brini M; Department of Biology, Centro Studi per la Neurodegenerazione (CESNE), University of Padua, Padua, Italy., Villani S; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Del Grosso E; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Grilli M; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Manfredi M; Department of Translational Medicine, Center for Translational Research on Autoimmune and Allergic Diseases (CAAD), Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Corazzari M; Department of Health Science (DSS), Center for Translational Research on Autoimmune and Allergic Disease (CAAD) & Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), Università del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy., Grolla AA; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy., Genazzani AA; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy. armando.genazzani@uniupo.it., Lim D; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', Via Bovio 6, 28100, Novara, Italy. dmitry.lim@uniupo.it.

Publikováno v: Cell death & disease [Cell Death Dis] 2022 Oct 18; Vol. 13 (10), pp. 878. Date of Electronic Publication: 2022 Oct 18.

Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids.

Autor: Mola S; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy.; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD), Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy., Pinton G; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy., Erreni M; Unit of Advanced Optical Microscopy, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy., Corazzari M; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD), Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy.; Department of Health Sciences, University of Piemonte Orientale 'A. Avogadro', 28100 Novara, Italy.; Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, 28100 Novara, Italy., De Andrea M; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD), Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy.; Department of Public Health and Pediatric Sciences, Medical School, University of Turin, 10126 Turin, Italy., Grolla AA; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy., Martini V; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD), Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy.; Department of Translational Medicine (DIMET), University of Piemonte Orientale 'A. Avogadro', 28100 Novara, Italy., Moro L; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy., Porta C; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy.; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD), Università del Piemonte Orientale 'Amedeo Avogadro', 28100 Novara, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Apr 22; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 22.

Editorial: Liquid Biopsy as a Tool for Precision Oncology: New Challenges to Assess Clinical Response.

Autor: Ravegnini G; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., Del Re M; Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Grolla AA; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Novara, Italy., van Schaik RHN; Department of Clinical Chemistry, Erasmus MC, Rotterdam, Netherlands., Angelini S; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2020 Oct 07; Vol. 11, pp. 598261. Date of Electronic Publication: 2020 Oct 07 (Print Publication: 2020).

Neutralization of extracellular NAMPT (nicotinamide phosphoribosyltransferase) ameliorates experimental murine colitis.

Autor: Colombo G; Department of Pharmaceutical Sciences, University of Eastern Piedmont, A. Avogadro, 28100, Novara, Italy., Clemente N; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD), Università del Piemonte Orientale, 28100, Novara, Italy., Zito A; Lab of Immunogenetics, Department of Medical Sciences, University of Turin, 10100, Turin, Italy., Bracci C; Lab of Immunogenetics, Department of Medical Sciences, University of Turin, 10100, Turin, Italy., Colombo FS; Flow Cytometry and Cell Sorting Unit, Humanitas Clinical and Research Center - IRCCS, 20089, Rozzano, MI, Italy., Sangaletti S; Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Jachetti E; Molecular Immunology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy., Ribaldone DG; Department of Surgical Sciences, University of Turin, 10100, Turin, Italy., Caviglia GP; Division of Gastroenterology, Department of Medical Sciences, University of Turin, 10100, Turin, Italy., Pastorelli L; Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.; Gastroenterology Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy., De Andrea M; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD), Università del Piemonte Orientale, 28100, Novara, Italy.; Viral Pathogenesis Unit, Department of Public Health and Pediatric Sciences, Turin Medical School, 10126, Turin, Italy., Naviglio S; Institute for Maternal and Child Health IRCCS Burlo Garofolo, 34137, Trieste, Italy., Lucafò M; Department of Medicine, Surgery and Health Sciences, University of Trieste, 34137, Trieste, Italy., Stocco G; Department of Life Sciences, University of Trieste, 34137, Trieste, Italy., Grolla AA; Department of Pharmaceutical Sciences, University of Eastern Piedmont, A. Avogadro, 28100, Novara, Italy., Campolo M; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina (ME), Messina, ME, Italy., Casili G; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina (ME), Messina, ME, Italy., Cuzzocrea S; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina (ME), Messina, ME, Italy., Esposito E; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina (ME), Messina, ME, Italy., Malavasi F; Lab of Immunogenetics, Department of Medical Sciences, University of Turin, 10100, Turin, Italy., Genazzani AA; Department of Pharmaceutical Sciences, University of Eastern Piedmont, A. Avogadro, 28100, Novara, Italy., Porta C; Department of Pharmaceutical Sciences, University of Eastern Piedmont, A. Avogadro, 28100, Novara, Italy. chiara.porta@uniupo.it.; Center for Translational Research on Autoimmune & Allergic Diseases (CAAD), Università del Piemonte Orientale, 28100, Novara, Italy. chiara.porta@uniupo.it., Travelli C; Department of Pharmaceutical Sciences, Università degli Studi di Pavia, 27100, Pavia, Italy. cristina.travelli@unipv.it.

Publikováno v: Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2020 Apr; Vol. 98 (4), pp. 595-612. Date of Electronic Publication: 2020 Apr 27.