Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

Autor: Wakefield B; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.; Western's Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, Ontario, Canada., Tang J; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.; Western's Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, Ontario, Canada., Hutchinson JL; Western's Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, Ontario, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada., Kanji R; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada., Brooks C; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada., Grol MW; Western's Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, Ontario, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada., Séguin CA; Western's Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, Ontario, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada., Penuela S; Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.; Western's Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, Ontario, Canada., Beier F; Western's Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, Ontario, Canada.; Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2024 Aug; Vol. 42 (8), pp. 1696-1709. Date of Electronic Publication: 2024 Mar 18.

Editorial: The immune system and inflammation in musculoskeletal health, aging, and disease.

Autor: Baht GS; Department of Orthopaedic Surgery, Duke Molecular Physiology Institute, Duke University, Durham, NC, United States., Grol MW; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 May 18; Vol. 14, pp. 1218118. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).

Tendon and motor phenotypes in the Crtap ^-/- mouse model of recessive osteogenesis imperfecta.

Autor: Grol MW; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States., Haelterman NA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States., Lim J; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States., Munivez EM; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States., Archer M; Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, United States., Hudson DM; Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, United States., Tufa SF; Shriners Hospital for Children, Portland, United States., Keene DR; Shriners Hospital for Children, Portland, United States., Lei K; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States., Park D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States., Kuzawa CD; Department of Orthopaedic Surgery, UT Health Sciences Center, Houston, United States., Ambrose CG; Department of Orthopaedic Surgery, UT Health Sciences Center, Houston, United States., Eyre DR; Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, United States., Lee BH; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.

Publikováno v: ELife [Elife] 2021 May 26; Vol. 10. Date of Electronic Publication: 2021 May 26.

Leukocyte-dependent effects of platelet-rich plasma on cartilage loss and thermal hyperalgesia in a mouse model of post-traumatic osteoarthritis.

Autor: Jayaram P; H. Ben Taub Department of Physical Medicine & Rehabilitation, Baylor College of Medicine, Houston, TX, USA; Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX, USA., Liu C; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Dawson B; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Ketkar S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Patel SJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Lee BH; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Electronic address: blee@bcm.edu., Grol MW; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Electronic address: grol@bcm.edu.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2020 Oct; Vol. 28 (10), pp. 1385-1393. Date of Electronic Publication: 2020 Jul 03.

Combinatorial Prg4 and Il-1ra Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Post-Traumatic Osteoarthritis.

Autor: Stone A; 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.; 2 Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, Texas., Grol MW; 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas., Ruan MZC; 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas., Dawson B; 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas., Chen Y; 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas., Jiang MM; 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas., Song IW; 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas., Jayaram P; 3 H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.; 4 Department of Orthopedic Surgery, Baylor College of Medicine, Houston, Texas., Cela R; 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas., Gannon F; 5 Department of Pathology, Baylor College of Medicine, Houston, Texas., Lee BHL; 1 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

Publikováno v: Human gene therapy [Hum Gene Ther] 2019 Feb; Vol. 30 (2), pp. 225-235. Date of Electronic Publication: 2018 Oct 17.