Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors.

Autor: Minwoo Wie, Keon Woo Khim, Groehler IV, Arnold S., Soomin Heo, Junhyeok Woo, Kook Son, Lee, Eun A., Jae Sun Ra, Sung You Hong, Schärer, Orlando D., Jang Hyun Choi, Kyungjae Myung

Publikováno v: NAR Cancer; Sep2023, Vol. 5 Issue 3, p1-14, 14p

N⁶‑(2-Deoxy‑d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5‑N‑(2-hydroxy-3-buten-1-yl)-formamidopyrimidine Adducts of 1,3-Butadiene: Synthesis, Structural Identification, and Detection in Human Cells.

Autor: Groehler IV, Arnold S., Najjar, Dominic, Pujari, Suresh S., Sangaraju, Dewakar, Tretyakova, Natalia Y.

Publikováno v: Chemical Research in Toxicology; Sep2018, Vol. 31 Issue 9, p885-897, 13p

Alkylation of nucleobases by 2-chloro- N,N -diethylethanamine hydrochloride (CDEAH) sensitizes PARP1 -deficient tumors.

Autor: Wie M; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea., Khim KW; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea., Groehler Iv AS; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea., Heo S; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea., Woo J; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea., Son K; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea., Lee EA; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea., Ra JS; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea., Hong SY; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea., Schärer OD; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea., Choi JH; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea., Myung K; Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.

Publikováno v: NAR cancer [NAR Cancer] 2023 Aug 07; Vol. 5 (3), pp. zcad042. Date of Electronic Publication: 2023 Aug 07 (Print Publication: 2023).