Diverse anti-NMDAR autoantibodies from individuals with encephalitis.

Autor: Jamet Z; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France., Villega F; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France.; Department of Pediatric Neurology, CIC-1401, University Children's Hospital of Bordeaux, Bordeaux, France., Groc L; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France. laurent.groc@u-bordeaux.fr.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Nov 27. Date of Electronic Publication: 2024 Nov 27.

Ketamine alleviates NMDA receptor hypofunction through synaptic trapping.

Autor: Villéga F; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France; Department of Pediatric Neurology, CIC-1401, University Children's Hospital of Bordeaux, Bordeaux, France., Fernandes A; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Jézéquel J; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Uyttersprot F; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Benac N; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Zenagui S; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Bastardo L; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Gréa H; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Bouchet D; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Villetelle L; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Nicole O; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France., Rogemond V; Synaptopathies and Autoantibodies Team, Institut NeuroMyoGene-MeLis, INSERM U1314, CNRS UMR 5284, Université Claude Bernard Lyon1, 69373 Lyon, France; French Reference Centre on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, 69677 Bron, France., Honnorat J; Synaptopathies and Autoantibodies Team, Institut NeuroMyoGene-MeLis, INSERM U1314, CNRS UMR 5284, Université Claude Bernard Lyon1, 69373 Lyon, France; French Reference Centre on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique Pierre Wertheimer, 69677 Bron, France., Dupuis JP; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France. Electronic address: julien.dupuis@u-bordeaux.fr., Groc L; University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS UMR 5297, 33000 Bordeaux, France. Electronic address: laurent.groc@u-bordeaux.fr.

Publikováno v: Neuron [Neuron] 2024 Oct 09; Vol. 112 (19), pp. 3311-3328.e9. Date of Electronic Publication: 2024 Jul 23.

APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors.

Autor: Dunot J; Université Côte d'Azur, CNRS, INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany., Moreno S; Université Côte d'Azur, CNRS, INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France., Gandin C; Université Côte d'Azur, CNRS, INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France., Pousinha PA; Université Côte d'Azur, CNRS, INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France., Amici M; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK., Dupuis J; Université de Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, 33076 Bordeaux Cedex, France., Anisimova M; Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA., Winschel A; Department of Biology, Neurophysiology und Neurosensory Systems, TU Darmstadt, 64287 Darmstadt, Germany., Uriot M; Université de Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, 33076 Bordeaux Cedex, France., Petshow SJ; Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA., Mensch M; Université Côte d'Azur, CNRS, INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France., Bethus I; Université Côte d'Azur, CNRS, INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France., Giudici C; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany., Hampel H; Biomedical Center (BMC), Division of Metabolic Biochemistry, Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany., Wefers B; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany., Wurst W; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany; Institute of Developmental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany., Naumann R; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany., Ashby MC; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK., Laube B; Department of Biology, Neurophysiology und Neurosensory Systems, TU Darmstadt, 64287 Darmstadt, Germany., Zito K; Center for Neuroscience, University of California, Davis, Davis, CA 95618, USA., Mellor JR; Centre for Synaptic Plasticity, School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK., Groc L; Université de Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, 33076 Bordeaux Cedex, France., Willem M; Biomedical Center (BMC), Division of Metabolic Biochemistry, Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address: mwillem@med.uni-muenchen.de., Marie H; Université Côte d'Azur, CNRS, INSERM, Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France. Electronic address: marie@ipmc.cnrs.fr.

Publikováno v: Neuron [Neuron] 2024 Aug 21; Vol. 112 (16), pp. 2708-2720.e9. Date of Electronic Publication: 2024 Jun 14.

Positive Allosteric Modulation of NMDARs Prevents the Altered Surface Dynamics Caused by Patients' Antibodies.

Autor: Maudes E; From the Neuroimmunology Program (E.M., L.M., J.O.D.), Fundació Clinic per la Recerca Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), University of Barcelona, Spain; and University of Bordeaux (Z.J., L.G.), CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France., Jamet Z; From the Neuroimmunology Program (E.M., L.M., J.O.D.), Fundació Clinic per la Recerca Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), University of Barcelona, Spain; and University of Bordeaux (Z.J., L.G.), CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France., Marmolejo L; From the Neuroimmunology Program (E.M., L.M., J.O.D.), Fundació Clinic per la Recerca Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), University of Barcelona, Spain; and University of Bordeaux (Z.J., L.G.), CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France., Dalmau JO; From the Neuroimmunology Program (E.M., L.M., J.O.D.), Fundació Clinic per la Recerca Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), University of Barcelona, Spain; and University of Bordeaux (Z.J., L.G.), CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France., Groc L; From the Neuroimmunology Program (E.M., L.M., J.O.D.), Fundació Clinic per la Recerca Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), University of Barcelona, Spain; and University of Bordeaux (Z.J., L.G.), CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France.

Publikováno v: Neurology(R) neuroimmunology & neuroinflammation [Neurol Neuroimmunol Neuroinflamm] 2024 Jul; Vol. 11 (4), pp. e200261. Date of Electronic Publication: 2024 May 21.

Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony.

Autor: Ceanga M; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, 07747 Jena, Germany., Rahmati V; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, 07747 Jena, Germany., Haselmann H; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, 07747 Jena, Germany., Schmidl L; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, 07747 Jena, Germany., Hunter D; Université de Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, 33000 Bordeaux, France., Brauer AK; Institute of Clinical Neuroimmunology, Klinikum der Universität München, Ludwig Maximilians University Munich, Martinsried, Germany; Biomedical Center, Ludwig Maximilians University Munich, Martinsried, Germany., Liebscher S; Institute of Clinical Neuroimmunology, Klinikum der Universität München, Ludwig Maximilians University Munich, Martinsried, Germany; Biomedical Center, Ludwig Maximilians University Munich, Martinsried, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Kreye J; Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany; Department of Pediatric Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany., Prüss H; Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany., Groc L; Université de Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, 33000 Bordeaux, France., Hallermann S; Carl Ludwig Institute for Physiology, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany., Dalmau J; Catalan Institution for Research and Advanced Studies (ICREA) and IDIBAPS-Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain., Ori A; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany., Heckmann M; Department of Neurophysiology, Institute of Physiology, University of Würzburg, 97070 Würzburg, Germany., Geis C; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, 07747 Jena, Germany. Electronic address: christian.geis@med.uni-jena.de.

Publikováno v: Cell reports [Cell Rep] 2023 Oct 31; Vol. 42 (10), pp. 113166. Date of Electronic Publication: 2023 Sep 27.