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Identification and Biological Characterization of 6-Aryl-7-isopropylquinazolinones as Novel TRPV1 Antagonists that Are Effective in Models of Chronic Pain

Autor: J. Culshaw, Andrew, Bevan, Stuart, Christiansen, Martin, Copp, Prafula, Davis, Andrew, Davis, Clare, Dyson, Alex, K. Dziadulewicz, Edward, Edwards, Lee, Eggelte, Hendrikus, Fox, Alyson, Gentry, Clive, Groarke, Alex, Hallett, Allan, W. Hart, Terance, A. Hughes, Glyn, Knights, Sally, Kotsonis, Peter, Lee, Wai, Lyothier, Isabelle, McBryde, Andrew, McIntyre, Peter, Paloumbis, George, Panesar, Moh, Patel, Sadhana, Seiler, Max-Peter, Yaqoob, Mohammed, Zimmermann, Kaspar

Publikováno v: Journal of Medicinal Chemistry; January 2006, Vol. 49 Issue: 2 p471-474, 4p

Activation and Desensitisation of the Thyrotropin-Releasing Hormone Receptor Visualised by Monitoring Cellular Redistribution of a β-arrestin-1-Green Fluorescent Protein Fusion Protein

Autor: Groarke, Alex, Milligan, Graeme

Publikováno v: Biochemical Society Transactions; June 1999, Vol. 27 Issue: 3 pA118-A118, 1p

Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain.

Autor: Culshaw AJ; Novartis Institutes for Biomedical Research, London WC1E 6BS, UK. andrew.culshaw@novartis.com, Bevan S, Christiansen M, Copp P, Davis A, Davis C, Dyson A, Dziadulewicz EK, Edwards L, Eggelte H, Fox A, Gentry C, Groarke A, Hallett A, Hart TW, Hughes GA, Knights S, Kotsonis P, Lee W, Lyothier I, McBryde A, McIntyre P, Paloumbis G, Panesar M, Patel S, Seiler MP, Yaqoob M, Zimmermann K

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2006 Jan 26; Vol. 49 (2), pp. 471-4.