T cell responses to SARS-CoV-2 vaccination differ by disease-modifying therapy for multiple sclerosis

Autor: Asia-Sophia Wolf, Anthony Ravussin, Marton König, Mathias H. Øverås, Guri Solum, Ingrid Fadum Kjønstad, Adity Chopra, Trygve Holmøy, Hanne F. Harbo, Silje Watterdal Syversen, Kristin Kaasen Jørgensen, Einar August Høgestøl, Jon Torgils Vaage, Elisabeth G. Celius, Fridtjof Lund-Johansen, Ludvig A. Munthe, Gro Owren Nygaard, Siri Mjaaland

Publikováno v: JCI Insight, Vol 8, Iss 12 (2023)

Immune responses in people with multiple sclerosis (pwMS) receiving disease-modifying therapies (DMTs) have been of significant interest throughout the COVID-19 pandemic. Lymphocyte-targeting immunotherapies, including anti-CD20 treatments and sphing

Externí odkaz: https://doaj.org/article/5ba69269a3e644d2844eed3988e93d9c

Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study

Autor: Hanneke E. Hulst, Mona K. Beyer, Hanne F. Harbo, Lars T. Westlye, Gro Owren Nygaard, Samuele Ghezzo, Piotr Sowa, Thomas Espeseth, Dag Alnæs, Einar August Høgestøl

Publikováno v: Høgestøl, E A, Ghezzo, S, Nygaard, G O, Espeseth, T, Sowa, P, Beyer, M K, Harbo, H F, Westlye, L T, Hulst, H E & Alnæs, D 2021, ' Functional connectivity in multiple sclerosis modelled as connectome stability: A 5-year follow-up study ', Multiple Sclerosis Journal . https://doi.org/10.1177/13524585211030212
Multiple Sclerosis Journal. SAGE Publications Ltd

Background: Brain functional connectivity (FC) in multiple sclerosis (MS) is abnormal compared to healthy controls (HCs). More longitudinal studies in MS are needed to evaluate whether FC stability is clinically relevant. Objective: To compare functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb75faceea1d97350850c2930866769
https://doi.org/10.1177/13524585211030212

Risk of fingolimod rebound after switching to cladribine or rituximab in multiple sclerosis

Autor: Gro Owren Nygaard, Hilde Torgauten, Lars Skattebøl, Einar August Høgestøl, Piotr Sowa, Kjell-Morten Myhr, Øivind Torkildsen, Elisabeth Gulowsen Celius

Publikováno v: Multiple sclerosis and related disorders. 62

A sudden onset of extensive disease activity, including severe clinical relapse and extensive brain or spinal magnetic resonance imaging (MRI) lesions, termed "rebound" disease activity has been reported after withdrawal of fingolimod in patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efd09dea1c0c2c6c49dbc5e9575a5a6
https://pubmed.ncbi.nlm.nih.gov/35462167

Immunogenicity and Safety of a Third SARS-CoV-2 Vaccine Dose in Patients With Multiple Sclerosis and Weak Immune Response After COVID-19 Vaccination

Autor: Marton König, Hilde Marie Torgauten, The Trung Tran, Trygve Holmøy, John Torgils Vaage, Fridtjof Lund-Johansen, Gro Owren Nygaard

Publikováno v: JAMA Neurology

This cohort study investigates the immunogenicity and safety of a third SARS-CoV-2 vaccine dose in patients with multiple sclerosis who had a weak immune response to COVID-19 vaccination.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfd95c290f4c4c7b5d3e1aa10b87971
http://europepmc.org/articles/PMC8787678

Efficacy and safety of a third SARS-CoV-2 vaccination in multiple sclerosis vaccine non-responders

Autor: Marthias Herstad Overas, Hilde Marie Torgauten, Elisabeth Gulowsen Celius, Hanne F. Harbo, Trygve Holmøy, Siri Mjaaland, Adity Chopra, Tone Berge, Åslaug R. Lorentzen, Ludvig A. Munthe, Øivind Torkildsen, Fridtjof Lund-Johansen, Marton König, Stig Wergeland, Gro Owren Nygaard, Ingeborg S. Aaberge, Kjell-Morten Myhr, John T. Vaage

ImportanceVaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to protect against coronavirus disease of 2019 (COVID-19) is recommended for patients with multiple sclerosis (pwMS). However, approximately 80% of all pwMS tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f7999b1bc0bc9da166afedea205e687
https://doi.org/10.1101/2021.10.15.21264977