Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Grit Zahn"'
Autor:
Barbara Schwertner, George Dahdal, Wolfgang Jagla, Luis Grossmann, Konstantin Drexler, Michael P. Krahn, Katja Evert, Mark Berneburg, Sebastian Haferkamp, Christine Ziegler, Eric K. Parkinson, Grit Zahn, Maria E. Mycielska, Andreas Gaumann
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
We have recently shown that cancer cells of various origins take up extracellular citrate through the plasma membrane citrate carrier (pmCiC), a specific plasma membrane citrate transporter. Extracellular citrate is required to support cancer cell me
Externí odkaz:
https://doaj.org/article/0e8a6ba44376475d8a649d023b9f0b09
Autor:
Dipender Gill, Loukas Zagkos, Rubinder Gill, Thomas Benzing, Jens Jordan, Andreas L. Birkenfeld, Stephen Burgess, Grit Zahn
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Solute carrier family 13 member 5 (SLC13A5) is a Na+-coupled citrate co-transporter that mediates entry of extracellular citrate into the cytosol. SLC13A5 inhibition has been proposed as a target for reducing progression of kidney
Externí odkaz:
https://doaj.org/article/ed05579c4a774e6680913e20083f3975
Autor:
Grit Zahn, Hannes A. Baukmann, Jasmine Wu, Jens Jordan, Andreas L. Birkenfeld, Naomi Dirckx, Marco F. Schmidt
Publikováno v:
Metabolites, Vol 13, Iss 12, p 1186 (2023)
Reduced expression of the plasma membrane citrate transporter SLC13A5, also known as INDY, has been linked to increased longevity and mitigated age-related cardiovascular and metabolic diseases. Citrate, a vital component of the tricarboxylic acid cy
Externí odkaz:
https://doaj.org/article/01fe8716f85649ccbdeaaf5fbe349067
Autor:
Grit Zahn, Diana M. Willmes, Nermeen N. El-Agroudy, Christopher Yarnold, Richard Jarjes-Pike, Sabine Schaertl, Kay Schreiter, Wiebke Gehrmann, Andrea Kuan Cie Wong, Tommaso Zordan, Jörg König, Jens Jordan, Andreas L. Birkenfeld
Publikováno v:
Metabolites, Vol 12, Iss 8, p 732 (2022)
Mammalian INDY (mINDY, NaCT, gene symbol SLC13A5) is a potential target for the treatment of metabolically associated fatty liver disease (MAFLD). This study evaluated the effects of a selective, cross-species active, non-competitive, non-substrate-l
Externí odkaz:
https://doaj.org/article/df864a926cf9414baf12212f6718bd61
Autor:
NERMEEN EL-AGROUDY, GRIT ZAHN, CHRISTINE HERRMANN, GELTRUDE MINGRONE, TIAGO C. ALVES, ANDREAS L. BIRKENFELD
Publikováno v:
Diabetes. 71
Background: Recent data proposed a role of the citrate transporter INDY (I’m Not Dead Yet) in the development of obesity, insulin resistance and NAFLD suggesting its potential as a therapeutic target for metabolic-related disorders. The aim of our
Autor:
E. Kenneth Parkinson, Jerzy Adamski, Grit Zahn, Andreas Gaumann, Fabian Flores-Borja, Christine Ziegler, Maria E. Mycielska
Publikováno v:
Cancer Metastasis Rev., DOI: 10.1007/s10555-021-10007-1 (2021)
It is well established that cancer cells acquire energy via the Warburg effect and oxidative phosphorylation. Citrate is considered to play a crucial role in cancer metabolism by virtue of its production in the reverse Krebs cycle from glutamine. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf7b59659e08f50312499b82baf230c
https://epub.uni-regensburg.de/51272/
https://epub.uni-regensburg.de/51272/
Autor:
Mario G. Fsadni, Evelien Vandewalle, Lieve Moons, Ingeborg Stalmans, Patrizia Caldirola, Grit Zahn, Tine Van Bergen, Ninus Caram-Lelham
Purpose To evaluate the therapeutic potential of the small molecule integrin α5β1 inhibitor, CLT-28643, to improve the filtering surgery outcome in a mouse model. Different dose regimens and administration routes of the inhibitor were compared with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158fafd267763d418799017914d30231
https://lirias.kuleuven.be/handle/123456789/558002
https://lirias.kuleuven.be/handle/123456789/558002
Autor:
Mario G. Fsadni, Maximilian Schultheiss, Karl U. Bartz-Schmidt, Martin S. Spitzer, Ninus Caram-Lelham, Eva-Maria Konrad, Sven Schnichels, Patrizia Caldirola, Grit Zahn
Publikováno v:
Acta ophthalmologica. 95(1)
Purpose Glaucoma filtration surgery (GFS) fails due to fibrosis. The α5β1-integrin plays a pivotal role in fibrosis, angiogenesis and inflammation. This is the first experiment evaluating the prevention of fibrosis after GFS by a specific small mol
Autor:
Ettore Novellino, Alexander Bochen, Grit Zahn, Luciana Marinelli, Herbert B. Schiller, Andreas O. Frank, Carlos Mas-Moruno, Sandro Cosconati, Horst Kessler, Roland Stragies, Dörte Vossmeyer, Elke Otto
Publikováno v:
Angewandte Chemie. 122:9465-9468
Autor:
Grit Zahn, Ettore Novellino, Roland Stragies, Luciana Marinelli, Vittorio Limongelli, Dominik Heckmann, Horst Kessler, Burkhardt Laufer
Publikováno v:
Angewandte Chemie. 121:4501-4506
Substitution einer Carboxygruppe: Alle Integrinrezeptoren binden ihre Liganden, die einen Aspartatrest enthalten, in der Metallionen-abhangigen Adhasionsstelle (MIDAS). Bislang waren alle Versuche, die Carboxygruppe durch andere isostere Gruppen mit