Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Grit Bornschein"'
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 11 (2020)
The efficacy of neocortical synapses to transmit during bursts of action potentials (APs) increases during development but the underlying mechanisms are largely unclear. We investigated synaptic efficacy at synapses between layer 5 pyramidal neurons
Externí odkaz:
https://doaj.org/article/36fbfc4b18f24ccfa0fc7bfd5fad9e49
Autor:
Valentin Kusch, Grit Bornschein, Desiree Loreth, Julia Bank, Johannes Jordan, David Baur, Masahiko Watanabe, Akos Kulik, Manfred Heckmann, Jens Eilers, Hartmut Schmidt
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 1965-1973 (2018)
Summary: Spatial relationships between Cav channels and release sensors at active zones (AZs) are a major determinant of synaptic fidelity. They are regulated developmentally, but the underlying molecular mechanisms are largely unclear. Here, we show
Externí odkaz:
https://doaj.org/article/d79708ffd3ba4fe7b33f564a3eeceab0
Autor:
Grit Bornschein, Hartmut Schmidt
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2019)
Ca2+ concentrations drop rapidly over a distance of a few tens of nanometers from an open voltage-gated Ca2+ channel (Cav), thereby, generating a spatially steep and temporally short-lived Ca2+ gradient that triggers exocytosis of a neurotransmitter
Externí odkaz:
https://doaj.org/article/73d8c1301814434e80596ff9daafb2d7
Autor:
Magdalena Wender, Grit Bornschein, Simone Brachtendorf, Stefan Hallermann, Jens Eilers, Hartmut Schmidt
Publikováno v:
The Journal of Neuroscience. 43:4005-4018
The composition of voltage-gated Ca2+channel (Cav) subtypes that gate action potential (AP)-evoked release changes during the development of mammalian CNS synapses. Cav2.2 and Cav2.3 lose their function in gating-evoked release during postnatal synap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c19708409827f73c4021430dc165de1
https://doi.org/10.1523/jneurosci.1279-22.2023
https://doi.org/10.1523/jneurosci.1279-22.2023
Autor:
Iron Weichard, Holger Taschenberger, Felix Gsell, Grit Bornschein, Andreas Ritzau-Jost, Hartmut Schmidt, Robert J. Kittel, Jens Eilers, Erwin Neher, Stefan Hallermann, Jana Nerlich
Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer 5 pyramidal neurons LTP increases the initial synaptic strength but also short-term depression during high-frequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7930d6f51f14370cc4c146801fc9c61c
https://doi.org/10.1101/2023.04.11.535831
https://doi.org/10.1101/2023.04.11.535831
Autor:
Mila M Paul, Sven Dannhäuser, Lydia Morris, Achmed Mrestani, Martha Hübsch, Jennifer Gehring, Georgios N Hatzopoulos, Martin Pauli, Genevieve M Auger, Grit Bornschein, Nicole Scholz, Dmitrij Ljaschenko, Martin Müller, Markus Sauer, Hartmut Schmidt, Robert J Kittel, Aaron DiAntonio, Ioannis Vakonakis, Manfred Heckmann, Tobias Langenhan
Publikováno v:
Brain. 145:3787-3802
Humans carrying the CORD7 (cone-rod dystrophy 7) mutation possess increased verbal IQ and working memory. This autosomal dominant syndrome is caused by the single-amino acid R844H exchange (human numbering) located in the 310 helix of the C2A domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e229fbac4d1fe4e89715e64bf18abcc
https://doi.org/10.1093/brain/awac011
https://doi.org/10.1093/brain/awac011
Autor:
David Baur, Valentin Kusch, Desiree Loreth, Akos Kulik, Hartmut Schmidt, Grit Bornschein, Julia Bank, Masahiko Watanabe, Jens Eilers, Johannes Jordan, Manfred Heckmann
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 1965-1973 (2018)
Summary Spatial relationships between Ca v channels and release sensors at active zones (AZs) are a major determinant of synaptic fidelity. They are regulated developmentally, but the underlying molecular mechanisms are largely unclear. Here, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585ab1326908b1c97e839557779d2fca
http://www.sciencedirect.com/science/article/pii/S2211124718301785
http://www.sciencedirect.com/science/article/pii/S2211124718301785
Publikováno v:
Frontiers in Synaptic Neuroscience
The efficacy of neocortical synapses to transmit during bursts of action potentials (APs) increases during development but the underlying mechanisms are largely unclear. We investigated synaptic efficacy at synapses between layer 5 pyramidal neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29ad988f28e353eefba6083b384ffc3a
https://pubmed.ncbi.nlm.nih.gov/32009937
https://pubmed.ncbi.nlm.nih.gov/32009937
Publikováno v:
Cell reports. 28(6)
Coupling distances between Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df627fe9e9b2d8b73720c217c9f776d6
https://pubmed.ncbi.nlm.nih.gov/31390556
https://pubmed.ncbi.nlm.nih.gov/31390556
Publikováno v:
SSRN Electronic Journal.
Coupling distances between Ca2+ channels and release sensors regulate the vesicular release probability (pr). Tight coupling is thought to provide a framework for high pr and loose coupling for high plasticity at low pr. At synapses investigated duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5f32542de7831550d99f4330ae3a99
https://doi.org/10.2139/ssrn.3353704
https://doi.org/10.2139/ssrn.3353704