Neoantigen-specific stem cell memory-like CD4 ⁺ T cells mediate CD8 ⁺ T cell-dependent immunotherapy of MHC class II-negative solid tumors.

Autor: Brightman SE; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA, USA.; Biomedical Sciences Program, School of Medicine, University of California San Diego, La Jolla, CA, USA., Becker A; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA, USA., Thota RR; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA, USA., Naradikian MS; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA, USA., Chihab L; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA., Zavala KS; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA, USA., Ramamoorthy Premlal AL; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA., Griswold RQ; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA, USA.; Biomedical Sciences Program, School of Medicine, University of California San Diego, La Jolla, CA, USA., Dolina JS; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA, USA., Cohen EEW; Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, UCSD, La Jolla, CA, USA., Miller AM; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA, USA.; Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, UCSD, La Jolla, CA, USA., Peters B; Division of Hematology and Oncology, University of California San Diego Moores Cancer Center, UCSD, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Schoenberger SP; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA, USA. sps@lji.org.

Publikováno v: Nature immunology [Nat Immunol] 2023 Aug; Vol. 24 (8), pp. 1345-1357. Date of Electronic Publication: 2023 Jul 03.

TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4 ⁺ T Cells to T reg .

Autor: Dolina JS; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA. Electronic address: jdolina@lji.org., Lee J; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Griswold RQ; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Labarta-Bajo L; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA., Kannan S; Bioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Greenbaum JA; Bioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Bahia El Idrissi N; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Neurogenetics, Academic Medical Center, Amsterdam, the Netherlands., Pont MJ; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Croft M; Division of Immune Regulation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Schoenberger SP; Division of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA. Electronic address: sps@lji.org.

Publikováno v: Cell reports [Cell Rep] 2020 Apr 07; Vol. 31 (1), pp. 107249.