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Akademický článek

Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of Na V 1.7.

Autor: Sun S; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada. Electronic address: ssun@xenon-pharma.com., Chowdhury S; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Hemeon I; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Hasan A; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Wilson MS; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Bergeron P; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., Jia Q; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Zenova AY; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Grimwood ME; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Gong W; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Decker SM; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Bichler P; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Andrez JC; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Focken T; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Ngyuen T; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., Zhu J; Chempartner, Building No. 5, 998 Halei Rd., Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai, PR China., White AD; Chempartner, Building No. 5, 998 Halei Rd., Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai, PR China., Bankar G; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Howard S; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., Chang E; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Khakh K; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Lin S; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Dean R; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Johnson JP Jr; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Chang JH; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., Hackos DH; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., McKerrall SJ; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., Sellers B; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., Ortwine DF; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., Cohen CJ; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Safina BS; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., Sutherlin DP; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080-4990, USA., Dehnhardt CM; Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 21, pp. 130033. Date of Electronic Publication: 2024 Nov 21.

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Akademický článek

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na V 1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.

Autor: Focken T; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Burford K; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Grimwood ME; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Zenova A; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Andrez JC; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Gong W; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Wilson M; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Taron M; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Decker S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Lofstrand V; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Chowdhury S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Shuart N; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Lin S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Goodchild SJ; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Young C; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Soriano M; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Tari PK; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Waldbrook M; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Nelkenbrecher K; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Kwan R; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Lindgren A; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., de Boer G; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Lee S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Sojo L; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., DeVita RJ; RJD Medicinal Chemistry and Drug Discovery Consulting LLC , Westfield , New Jersey 07090 , United States., Cohen CJ; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Wesolowski SS; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Johnson JP Jr; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Dehnhardt CM; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Empfield JR; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Nov 14; Vol. 62 (21), pp. 9618-9641. Date of Electronic Publication: 2019 Oct 03.

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Akademický článek

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (Na V ) 1.7 with Potent Analgesic Activity.

Autor: Sun S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Jia Q; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Zenova AY; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Wilson MS; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Chowdhury S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Focken T; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Li J; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., Decker S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Grimwood ME; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Andrez JC; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Hemeon I; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Sheng T; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Chen CA; ChemPartner , Building No. 5, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area , Shanghai 201203 , P. R. China., White A; ChemPartner , Building No. 5, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area , Shanghai 201203 , P. R. China., Hackos DH; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., Deng L; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., Bankar G; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Khakh K; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Chang E; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Kwan R; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Lin S; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Nelkenbrecher K; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Sellers BD; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., DiPasquale AG; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., Chang J; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., Pang J; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., Sojo L; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Lindgren A; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Waldbrook M; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Xie Z; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Young C; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Johnson JP; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Robinette CL; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Cohen CJ; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada., Safina BS; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., Sutherlin DP; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., Ortwine DF; Genentech Inc. , 1 DNA Way , South San Francisco , California 94080-4990 , United States., Dehnhardt CM; Xenon Pharmaceuticals Inc. , 200-3650 Gilmore Way , Burnaby , British Columbia V5G 4W8 , Canada.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Jan 24; Vol. 62 (2), pp. 908-927. Date of Electronic Publication: 2018 Dec 21.

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Akademický článek

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa V 1.7 Inhibitors for the Treatment of Pain.

Autor: Focken T; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Chowdhury S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Zenova A; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Grimwood ME; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Chabot C; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Sheng T; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Hemeon I; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Decker SM; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Wilson M; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Bichler P; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Jia Q; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Sun S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Young C; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Lin S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Goodchild SJ; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Shuart NG; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Chang E; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Xie Z; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Li B; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Khakh K; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Bankar G; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Waldbrook M; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Kwan R; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Nelkenbrecher K; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Karimi Tari P; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Chahal N; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Sojo L; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Robinette CL; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., White AD; Chempartner , Building No. 5, 998 Halei Rd. , Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203 , China., Chen CA; Chempartner , Building No. 5, 998 Halei Rd. , Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203 , China., Zhang Y; Chempartner , Building No. 5, 998 Halei Rd. , Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203 , China., Pang J; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Chang JH; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Hackos DH; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Johnson JP Jr; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Cohen CJ; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Ortwine DF; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Sutherlin DP; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States., Dehnhardt CM; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada., Safina BS; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Jun 14; Vol. 61 (11), pp. 4810-4831. Date of Electronic Publication: 2018 May 23.

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Akademický článek

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.

Autor: Focken T; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Liu S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Chahal N; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Dauphinais M; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Grimwood ME; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Chowdhury S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Hemeon I; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Bichler P; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Bogucki D; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Waldbrook M; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Bankar G; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Sojo LE; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Young C; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Lin S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Shuart N; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Kwan R; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Pang J; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Chang JH; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Safina BS; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Sutherlin DP; Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States., Johnson JP Jr; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Dehnhardt CM; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Mansour TS; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Oballa RM; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Cohen CJ; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Robinette CL; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2016 Jan 19; Vol. 7 (3), pp. 277-82. Date of Electronic Publication: 2016 Jan 19 (Print Publication: 2016).

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Akademický článek

The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.

Autor: Sun S; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada. Electronic address: ssun@xenon-pharma.com., Jia Q; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Zenova AY; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Chafeev M; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Zhang Z; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Lin S; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Kwan R; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Grimwood ME; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Chowdhury S; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Young C; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Cohen CJ; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada., Oballa RM; Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Sep 15; Vol. 24 (18), pp. 4397-4401. Date of Electronic Publication: 2014 Aug 14.

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