Exposure of Escherichia coli to antibiotic-efflux pump inhibitor combinations in a pharmacokinetic model: impact on bacterial clearance and drug resistance.

Autor: MacGowan AP; Bristol Centre for Antimicrobial Research & Evaluation (BCARE), Infection Sciences, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK., Attwood MLG; Bristol Centre for Antimicrobial Research & Evaluation (BCARE), Infection Sciences, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK., Noel AR; Bristol Centre for Antimicrobial Research & Evaluation (BCARE), Infection Sciences, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK., Barber R; Microbiotix Inc, 1 Innovation Drive, Worcester, MA 01605, USA., Aron Z; Microbiotix Inc, 1 Innovation Drive, Worcester, MA 01605, USA., Opperman TJ; Microbiotix Inc, 1 Innovation Drive, Worcester, MA 01605, USA., Grimsey E; Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Stone J; Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Ricci V; Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Piddock LJV; Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2023 Dec 01; Vol. 78 (12), pp. 2869-2877.

Screening and Optimizing Antimicrobial Peptides by Using SPOT-Synthesis

Autor: López-Pérez, PM, Grimsey, E, Bourne, L, Mikut, R, Hilpert, K

Publikováno v: Frontiers in Chemistry
Frontiers in Chemistry, 5, Article 25
Front Chem

Peptide arrays on cellulose are a powerful tool to investigate peptide interactions with a number of different molecules, for examples antibodies, receptors or enzymes. Such peptide arrays can also be used to study interactions with whole cells. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24050138b0cf939089750d2c736bdf12

Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB.

Autor: Reading E; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK. eamonn.reading@kcl.ac.uk., Ahdash Z; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK., Fais C; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy., Ricci V; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK., Wang-Kan X; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK., Grimsey E; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK., Stone J; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK., Malloci G; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy., Lau AM; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK., Findlay H; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK., Konijnenberg A; Thermo Fisher Scientific, Zwaanstraat 31G/H, 5651 CA, Eindhoven, The Netherlands., Booth PJ; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK., Ruggerone P; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy., Vargiu AV; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy., Piddock LJV; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK., Politis A; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK. argyris.politis@kcl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2020 Nov 04; Vol. 11 (1), pp. 5565. Date of Electronic Publication: 2020 Nov 04.

Temperature sensitive point mutations in fission yeast tropomyosin have long range effects on the stability and function of the actin-tropomyosin copolymer.

Autor: Johnson CA; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Brooker HR; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Gyamfi I; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., O'Brien J; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Ashley B; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Brazier JE; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Dean A; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Embling J; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Grimsey E; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Tomlinson AC; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Wilson EG; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK., Geeves MA; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK. Electronic address: m.a.geeves@kent.ac.uk., Mulvihill DP; School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK. Electronic address: d.p.mulvihill@kent.ac.uk.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Nov 25; Vol. 506 (2), pp. 339-346. Date of Electronic Publication: 2017 Nov 01.

Expression and Purification of Cp3GT: Structural Analysis and Modeling of a Key Plant Flavonol-3-O Glucosyltransferase from Citrus paradisi.

Autor: Birchfield, Aaron S.¹ (AUTHOR) birchfieldas@etsu.edu, McIntosh, Cecilia A.¹ (AUTHOR) mcintosc@etsu.edu

Publikováno v: BioTech. Mar2024, Vol. 13 Issue 1, p4. 31p.