A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.

Autor: Jäger K; Institute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, University of Rostock, Rostock, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany., Mensch J; Institute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, University of Rostock, Rostock, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany., Grimmig ME; Institute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, University of Rostock, Rostock, Germany., Neuner B; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Berlin, Germany., Gorzelniak K; Unfallkrankenhaus Berlin, Institute of Laboratory Medicine, Berlin, Germany., Türkmen S; LNS Hematooncogenetics, National Center of Genetics Luxembourg, Dudelange, Luxemburg.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Medical Genetics and Human Genetics, Berlin, Germany., Demuth I; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany., Hartmann A; Institute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, University of Rostock, Rostock, Germany., Hartmann C; Translational Neurodegeneration Section 'Albrecht-Kossel', Department of Neurology, Rostock University Medical Center, University of Rostock, 18147 Rostock, Germany., Wittig F; Institute of Pharmacology and Toxicology, Rostock University Medical Center, University of Rostock, Rostock, Germany., Sporbert A; Advanced Light Microscopy, Max Delbrück Center for Molecular Medicine, Berlin, Germany., Hermann A; Translational Neurodegeneration Section 'Albrecht-Kossel', Department of Neurology, Rostock University Medical Center, University of Rostock, 18147 Rostock, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Rostock/Greifswald, Rostock, Germany.; Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, Rostock, Germany., Fuellen G; Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany., Möller S; Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany., Walter M; Institute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, University of Rostock, Rostock, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Berlin, Germany.

Publikováno v: Science advances [Sci Adv] 2022 Aug 19; Vol. 8 (33), pp. eabk2814. Date of Electronic Publication: 2022 Aug 17.