Next generation risk assessment for occupational chemical safety - A real world example with sodium-2-hydroxyethane sulfonate.

Autor: Wood A; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK. Electronic address: adam.wood@unilever.com., Breffa C; Clariant Produkte (Deutschland) GmbH, Frankfurt am Main, Germany., Chaine C; Vantage Specialty Chemicals, 3 rue Jules Guesde, Ris Orangis 91130, France., Cubberley R; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Dent M; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Eichhorn J; Clariant Produkte (Deutschland) GmbH, Frankfurt am Main, Germany., Fayyaz S; Clariant Produkte (Deutschland) GmbH, Frankfurt am Main, Germany., Grimm FA; Clariant Produkte (Deutschland) GmbH, Frankfurt am Main, Germany., Houghton J; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Kiwamoto R; Unilever, Bronland 14, Wageningen 6708 WH, the Netherlands., Kukic P; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Lee M; Clariant Produkte (Deutschland) GmbH, Frankfurt am Main, Germany., Malcomber S; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Martin S; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Nicol B; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Reynolds J; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Riley G; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Scott S; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Smith C; ERM Ireland Limited, Ardilaun Court, St Stephen's Green, Dublin, Ireland., Westmoreland C; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Wieland W; ERM, Catherijnesingel 47, Utrecht 3511GC, the Netherlands., Williams M; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Wolton K; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK., Zellmann T; Vantage Leuna, Am Haupttor, Gebäude 7302, Leuna 06237, Germany., Gutsell S; Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK.

Publikováno v: Toxicology [Toxicology] 2024 Aug; Vol. 506, pp. 153835. Date of Electronic Publication: 2024 Jun 08.

Integrative Chemical-Biological Grouping of Complex High Production Volume Substances from Lower Olefin Manufacturing Streams.

Autor: Cordova AC; Interdisciplinary Faculty of Toxicology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.; Department of Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA., Klaren WD; Interdisciplinary Faculty of Toxicology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.; Department of Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA., Ford LC; Interdisciplinary Faculty of Toxicology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.; Department of Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA., Grimm FA; Interdisciplinary Faculty of Toxicology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.; Department of Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA., Baker ES; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Zhou YH; Departments of Statistics and Biological Sciences and Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27606, USA., Wright FA; Departments of Statistics and Biological Sciences and Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27606, USA., Rusyn I; Interdisciplinary Faculty of Toxicology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.; Department of Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.

Publikováno v: Toxics [Toxics] 2023 Jul 05; Vol. 11 (7). Date of Electronic Publication: 2023 Jul 05.

Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays.

Autor: House JS; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA.; Biostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, RTP, NC, USA., Grimm FA; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA., Klaren WD; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.; current address: ToxStrategies, Inc., Asheville, NC, USA., Dalzell A; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Harwell Science Campus, Oxon, UK., Kuchi S; Northern Ireland Centre for Stratified Medicine, Ulster University, L/Derry, Northern Ireland, UK.; current address: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Zhang SD; Northern Ireland Centre for Stratified Medicine, Ulster University, L/Derry, Northern Ireland, UK., Lenz K; SYNCOM Forschungs und Entwicklungsberatung GmbH, Ganderkesee, Germany., Boogaard PJ; SHELL International BV, The Hague, The Netherlands., Ketelslegers HB; Concawe, Brussels, Belgium., Gant TW; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Harwell Science Campus, Oxon, UK., Rusyn I; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA., Wright FA; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA.

Publikováno v: ALTEX [ALTEX] 2022; Vol. 39 (3), pp. 388–404. Date of Electronic Publication: 2022 Mar 10.

Revealing Adverse Outcome Pathways from Public High-Throughput Screening Data to Evaluate New Toxicants by a Knowledge-Based Deep Neural Network Approach.

Autor: Ciallella HL; Center for Computational and Integrative Biology, Rutgers University Camden, Camden, New Jersey 08103, United States., Russo DP; Center for Computational and Integrative Biology, Rutgers University Camden, Camden, New Jersey 08103, United States.; Department of Chemistry, Rutgers University Camden, Camden, New Jersey 08102, United States., Aleksunes LM; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey 08854, United States., Grimm FA; ExxonMobil Biomedical Sciences, Inc., Annandale, New Jersey 08801, United States., Zhu H; Center for Computational and Integrative Biology, Rutgers University Camden, Camden, New Jersey 08103, United States.; Department of Chemistry, Rutgers University Camden, Camden, New Jersey 08102, United States.

Publikováno v: Environmental science & technology [Environ Sci Technol] 2021 Aug 03; Vol. 55 (15), pp. 10875-10887. Date of Electronic Publication: 2021 Jul 25.

Grouping of UVCB substances with new approach methodologies (NAMs) data.

Autor: House JS; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA.; current address: Biostatistics & Computational Biology Branch, National Institute of Environmental Health Sciences, RTP, NC, USA., Grimm FA; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.; current address: ExxonMobil Biomedical Sciences Inc., Annandale, NJ, USA., Klaren WD; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.; current address: S.C. Johnson and Son, Inc., Racine, WI, USA., Dalzell A; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Harwell Science Campus, Oxon, UK., Kuchi S; Northern Ireland Centre for Stratified Medicine, Ulster University, L/Derry, Northern Ireland, UK.; current address: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, UK., Zhang SD; Northern Ireland Centre for Stratified Medicine, Ulster University, L/Derry, Northern Ireland, UK., Lenz K; SYNCOM Forschungs- und Entwicklungsberatung GmbH, Ganderkesee, Germany., Boogaard PJ; SHELL International BV, The Hague, Netherlands.; Concawe, Brussels, Belgium., Ketelslegers HB; Concawe, Brussels, Belgium., Gant TW; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Harwell Science Campus, Oxon, UK., Wright FA; Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA., Rusyn I; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.

Publikováno v: ALTEX [ALTEX] 2021; Vol. 38 (1), pp. 123-137. Date of Electronic Publication: 2020 Oct 09.