Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Grillot AL"'
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4
Akademický článek
Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.
Autor: O'Dowd H; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Shannon DE; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Chandupatla KR; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Dixit V; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Engtrakul JJ; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Ye Z; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Jones SM; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., O'Brien CF; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospital , 80 Seymour Street, Hartford, Connecticut 06102, United States., Tessier PR; Center for Anti-Infective Research and Development, Hartford Hospital , 80 Seymour Street, Hartford, Connecticut 06102, United States., Crandon JL; Center for Anti-Infective Research and Development, Hartford Hospital , 80 Seymour Street, Hartford, Connecticut 06102, United States., Song B; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Macikenas D; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Hanzelka BL; Vertex Pharmaceuticals Incorporated , 2500 Crosspark Road, Bioventures Center, Coralville, Iowa 52241, United States., Le Tiran A; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bennani YL; Vertex Pharmaceuticals Incorporated , 275 Boulevard Armand Frappier, Laval, QC H7V 4A7, Canada., Charifson PS; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Grillot AL; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Jun 22; Vol. 6 (7), pp. 822-6. Date of Electronic Publication: 2015 Jun 22 (Print Publication: 2015).
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5
Akademický článek
Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency.
Autor: Henderson JA; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA. Electronic address: james_henderson@vrtx.com., Bilimoria D; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Bubenik M; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cadilhac C; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cottrell KM; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Dietrich E; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Denis F; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Ewing N; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Falardeau G; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Giroux S; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Grey R Jr; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., L'Heureux L; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Liu B; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Mani N; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Morris M; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Nicolas O; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Pereira OZ; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Poisson C; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Govinda Rao B; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Reddy TJ; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Selliah S; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Shawgo RS; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Vaillancourt L; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Wang J; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Yannopoulos CG; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Chauret N; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Berlioz-Seux F; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Chan LC; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Das SK; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Grillot AL; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Bennani YL; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Maxwell JP; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Feb 15; Vol. 25 (4), pp. 944-7. Date of Electronic Publication: 2014 Dec 20.
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6
Akademický článek
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers.
Autor: Giroux S; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Bilimoria D; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cadilhac C; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cottrell KM; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Denis F; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Dietrich E; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Ewing N; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Henderson JA; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., L'Heureux L; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Mani N; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Morris M; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Nicolas O; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Reddy TJ; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Selliah S; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Shawgo RS; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Xu J; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Chauret N; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Berlioz-Seux F; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Chan LC; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Das SK; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Grillot AL; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Bennani YL; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Maxwell JP; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Feb 15; Vol. 25 (4), pp. 936-9. Date of Electronic Publication: 2014 Dec 30.
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7
Akademický článek
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1b.
Autor: Giroux S; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA. Electronic address: simon_giroux@vrtx.com., Bilimoria D; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cadilhac C; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cottrell KM; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Denis F; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Dietrich E; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Ewing N; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Henderson JA; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., L'Heureux L; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Mani N; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Morris M; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Nicolas O; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Reddy TJ; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Selliah S; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Shawgo RS; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Xu J; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Chauret N; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Berlioz-Seux F; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Chan LC; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Das SK; Vertex Pharmaceuticals Canada Inc., 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Grillot AL; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Bennani YL; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA., Maxwell JP; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02210, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Feb 15; Vol. 25 (4), pp. 940-3. Date of Electronic Publication: 2014 Dec 29.
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8
Akademický článek
Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores.
Autor: Henderson JA; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA. Electronic address: james_henderson@vrtx.com., Bilimoria D; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Bubenik M; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cadilhac C; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Cottrell KM; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Denis F; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Dietrich E; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Ewing N; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Falardeau G; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Giroux S; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., L'Heureux L; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Liu B; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Mani N; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Morris M; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Nicolas O; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Pereira OZ; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Poisson C; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Reddy TJ; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Selliah S; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Shawgo RS; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Vaillancourt L; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Wang J; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Xu J; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Chauret N; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Berlioz-Seux F; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Chan LC; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Das SK; Vertex Pharmaceuticals Canada Incorporated, 275 Boul. Armand-Frappier, Laval, QC H7V 4A7, Canada., Grillot AL; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Bennani YL; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA., Maxwell JP; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, USA.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Feb 15; Vol. 25 (4), pp. 948-51. Date of Electronic Publication: 2014 Dec 22.
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9
Akademický článek
Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.
Autor: Grillot AL; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Le Tiran A, Shannon D, Krueger E, Liao Y, O'Dowd H, Tang Q, Ronkin S, Wang T, Waal N, Li P, Lauffer D, Sizensky E, Tanoury J, Perola E, Grossman TH, Doyle T, Hanzelka B, Jones S, Dixit V, Ewing N, Liao S, Boucher B, Jacobs M, Bennani Y, Charifson PS
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2014 Nov 13; Vol. 57 (21), pp. 8792-816. Date of Electronic Publication: 2014 Oct 28.
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10
Akademický článek
Successful application of serum shift prediction models to the design of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV with improved in vivo efficacy.
Autor: Perola E; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States. Electronic address: emanuele_perola@vrtx.com., Stamos D; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Grillot AL; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Ronkin S; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Wang T; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., LeTiran A; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Tang Q; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Deininger DD; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Liao Y; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Tian SK; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Drumm JE; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, United States., Tessier PR; Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, United States., Mani N; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Grossman TH; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States., Charifson PS; Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States.
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 May 01; Vol. 24 (9), pp. 2177-81. Date of Electronic Publication: 2014 Mar 19.
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