Polymorphic variants in NR1I3 and UGT2B7 predict taxane neurotoxicity and have prognostic relevance in breast cancer patients: a case-control study

Autor: Arbitrio Mariamena (1), Scionti Francesca (2), Altomare Emanuela (2), Di Martino Maria Teresa (2), Agapito Giuseppe (3), Galeano Teresa (2), Staropoli Nicoletta (4), Iuliano Eleonora(2), Grillone rancescaF (4), Fabiani Fernanda (5), Caracciolo Daniele (2), Cannataro Mario (3), Arpino Grazia (6), Santini Daniele (7), Tassone Pierfrancesco (2, Tagliaferri Pierosandro (2

Publikováno v: Clinical pharmacology and therapeutics (2019). doi:10.1002/cpt.1391
info:cnr-pdr/source/autori:Arbitrio Mariamena (1), Scionti Francesca (2), Altomare Emanuela (2), Di Martino Maria Teresa (2), Agapito Giuseppe (3), Galeano Teresa (2), Staropoli Nicoletta (4), Iuliano Eleonora(2), Grillone rancescaF (4), Fabiani Fernanda (5), Caracciolo Daniele (2), Cannataro Mario (3), Arpino Grazia (6), Santini Daniele (7), Tassone Pierfrancesco (2,3), Tagliaferri Pierosandro (2,3)/titolo:Polymorphic variants in NR1I3 and UGT2B7 predict taxane neurotoxicity and have prognostic relevance in breast cancer patients: a case-control study/doi:10.1002%2Fcpt.1391/rivista:Clinical pharmacology and therapeutics/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume

Taxane-related peripheral neuropathy (TrPN) is a dose-limiting toxicity with important inter-individual variability. Genetic polymorphisms in ADME genes may account for variability in drug efficacy and/or toxicity. By the use of Affymetrix DMETTM mic

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https://publications.cnr.it/doc/399806