Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Grigory Veinberg"'
Publikováno v:
Chromatographia. 85:489-495
Autor:
Jevgenijs Kuznecovs, Natalja Orlova, Sergey Belyakov, Grigory Veinberg, Maksims Vorona, Vladislavs Baskevics, Ilona Domračeva
Publikováno v:
Chemistry of Heterocyclic Compounds. 56:1297-1301
The ozonation of N-Boc-protected 3-methylidene-4-phenyl-5-(trifluoromethyl)pyrrolidin-2-one resulted in its transformation into 3-hydroxy-4-phenyl-5-(trifluoromethyl)-3-pyrrolin-2-one. Catalytic hydrogenation of its O-Boc-protected derivative introdu
Autor:
Natalja Orlova, Sergey Belyakov, Marina Petrova, Helena Kazoka, Vladislavs Baskevics, Ruslan Muhamadejev, Grigory Veinberg, Maxim Vorona
Publikováno v:
Chemistry of Heterocyclic Compounds. 56:997-1009
The addition of malonates to trans-β-alkyl-β-nitrostyrenes in the presence of chiral Mg2+ bisoxazoline complex and Ni2+ and Co2+ bis((S,S)- or (R,R)-N,N′-dibenzylcyclohexane-1,2-diamine) complexes resulted in the formation of Michael adducts with
Autor:
Jevgenijs Kuznecovs, Grigory Veinberg, Ainars Leonchiks, Sergey Belyakov, Maxim Vorona, Iveta Kanepe-Lapsa, Marina Petrova, Edvards Liepins, Ilona Domračeva
Publikováno v:
Chemistry of Heterocyclic Compounds. 54:514-519
The treatment of 1-acetyl-5-bromo-4-phenyl-3-pyrrolin-2-one with appropriate silver salts in benzene promotes the substitution of bromine with chloride, fluoride, nitrite, nitrate, and thiocyanate groups. Biological testing of the newly synthesized c
Autor:
Ilona Domracheva, Grigory Veinberg, Jevgenijs Kuznecovs, Maxim Vorona, Natalja Orlova, Liga Zvejniece, Edijs Vavers, Maija Dambrova
Publikováno v:
Chemistry of Heterocyclic Compounds. 51:601-606
Since the discovery of piracetam its structural analogs based on the pyrrolidin-2-one pharmacophore have aroused great interest as a source of effective pharmacological central nervous system agents capable to facilitate memory processes and to atten
The cognition‐enhancing activity of E1R , a novel positive allosteric modulator of sigma‐1 receptors
Autor:
Ivars Kalvinsh, Ilona Domracheva, Grigory Veinberg, Ilmars Stonans, Liga Zvejniece, Edijs Vavers, Reinis Vilskersts, Maxim Vorona, Ilga Misane, Maija Dambrova, Baiba Svalbe
Publikováno v:
British Journal of Pharmacology. 171:761-771
Background and Purpose Here, we describe the in vitro and in vivo effects of (4R,5S)-2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide (E1R), a novel positive allosteric modulator of sigma-1 receptors. Experimental Approach E1R was tested for sig
Publikováno v:
Current Medicinal Chemistry. 21:393-416
Since the discovery of penicillin, natural and synthetic β-lactams have aroused great interest not only as sources of effective antibacterial agents but also as specific inhibitors of proteases responsible for various non-bacterial pathological proc
Autor:
A. F. Mishnev, E. E. Liepin'sh, E. Kuznetsov, Natalja Orlova, S. Vikainis, Maksims Vorona, Sergey Belyakov, Grigory Veinberg
Publikováno v:
Chemistry of Heterocyclic Compounds. 49:1118-1127
An effective method for the conversion of 1-acetyl-4-phenyl-2-pyrrolidone into 1-acetyl-4-phenyl-3-pyrrolin-2-one by bromination–dehydrobromination with N-bromosuccinimide, catalyzed by azo-bisisobutyronitrile or by UV irradiation is developed. The
Autor:
Liga Zvejniece, Edijs Vavers, Jevgenijs Kuznecovs, Maxim Vorona, Ilona Domracheva, Maija Dambrova, Grigory Veinberg, Natalja Orlova
Publikováno v:
ChemInform. 47
Since the discovery of piracetam its structural analogs based on the pyrrolidin-2-one pharmacophore have aroused great interest as a source of effective pharmacological central nervous system agents capable to facilitate memory processes and to atten
Autor:
Grigory Veinberg, Liga Zvejniece, A. Chernobrovijs, Maksims Vorona, E. Kuznetsov, Maija Dambrova, S. Vikainis, Yu. Ponomarev, Anton Lebedev
Publikováno v:
Chemistry of Heterocyclic Compounds. 48:720-723
Two novel methods have been developed for the preparation of 2-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide ((R)-Phenotropil). In the first, n-butyl (3R)-4-amino-3-phenylbutyrate is alkylated with haloacetamide in DMF in the presence of potassium ph