Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Grigory V. Mechetin"'
Autor:
Evgeniia A. Diatlova, Grigory V. Mechetin, Anna V. Yudkina, Vasily D. Zharkov, Natalia A. Torgasheva, Anton V. Endutkin, Olga V. Shulenina, Andrey L. Konevega, Irina P. Gileva, Sergei N. Shchelkunov, Dmitry O. Zharkov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9113 (2023)
The protein encoded by the vaccinia virus D4R gene has base excision repair uracil–DNA N-glycosylase (vvUNG) activity and also acts as a processivity factor in the viral replication complex. The use of a protein unlike PolN/PCNA sliding clamps is a
Externí odkaz:
https://doaj.org/article/5385904e79d840849797b631547bd5f7
Autor:
Grigory V. Mechetin, Dmitry O. Zharkov
Publikováno v:
Genes, Vol 14, Iss 1, p 127 (2023)
Boron neutron capture therapy (BNCT) is an approach to the radiotherapy of solid tumors that was first outlined in the 1930s but has attracted considerable attention recently with the advent of a new generation of neutron sources. In BNCT, tumor cell
Externí odkaz:
https://doaj.org/article/4951e191bb864c1587bae2fd4661722a
Publikováno v:
Cells, Vol 11, Iss 20, p 3192 (2022)
Proteins that recognize specific DNA sequences or structural elements often find their cognate DNA lesions in a processive mode, in which an enzyme binds DNA non-specifically and then slides along the DNA contour by one-dimensional diffusion. Opposit
Externí odkaz:
https://doaj.org/article/246d1af67b3c4036a023220e59f355a0
Autor:
Natalia A. Torgasheva, Evgeniia A. Diatlova, Inga R. Grin, Anton V. Endutkin, Grigory V. Mechetin, Ivan P. Vokhtantsev, Anna V. Yudkina, Dmitry O. Zharkov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7286 (2022)
Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the
Externí odkaz:
https://doaj.org/article/5ba05e0ccff241558f62dc644478f9fd
Autor:
Inga R. Grin, Grigory V. Mechetin, Rustem D. Kasymov, Evgeniia A. Diatlova, Anna V. Yudkina, Sergei N. Shchelkunov, Irina P. Gileva, Alexandra A. Denisova, Grigoriy A. Stepanov, Ghermes G. Chilov, Dmitry O. Zharkov
Publikováno v:
Molecules, Vol 26, Iss 21, p 6668 (2021)
Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the effic
Externí odkaz:
https://doaj.org/article/4eccb9b2add64a62a6373d3ddfe88e90
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3118 (2020)
DNA glycosylases are enzymes that initiate the base excision repair pathway, a major biochemical process that protects the genomes of all living organisms from intrinsically and environmentally inflicted damage. Recently, base excision repair inhibit
Externí odkaz:
https://doaj.org/article/543422013b044080a9203e7ced879c72
Autor:
Rustem D. Kasymov, Evgeniia A. Diatlova, Grigoriy A. Stepanov, Grigory V. Mechetin, Ghermes G. Chilov, Anna V. Yudkina, I. P. Gileva, Dmitry O. Zharkov, Sergei N. Shchelkunov, Inga R. Grin, Alexandra A. Denisova
Publikováno v:
Molecules
Molecules, Vol 26, Iss 6668, p 6668 (2021)
Volume 26
Issue 21
Molecules, Vol 26, Iss 6668, p 6668 (2021)
Volume 26
Issue 21
Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the effic
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3118, p 3118 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 3118, p 3118 (2020)
DNA glycosylases are enzymes that initiate the base excision repair pathway, a major biochemical process that protects the genomes of all living organisms from intrinsically and environmentally inflicted damage. Recently, base excision repair inhibit
Autor:
Haoquan Li, Arthur J. Campbell, Carlos de los Santos, Nikita A. Kuznetsov, Arthur P. Grollman, Dmitry O. Zharkov, Grigory V. Mechetin, Carlos Simmerling, Christina Bergonzo, Olga S. Fedorova
Publikováno v:
Nucleic Acids Research
Formamidopyrimidine-DNA glycosylase (Fpg) excises 8-oxoguanine (oxoG) from DNA but ignores normal guanine. We combined molecular dynamics simulation and stopped-flow kinetics with fluorescence detection to track the events in the recognition of oxoG
Autor:
Dmitry O. Zharkov, Grigory V. Mechetin
Publikováno v:
Biochemical and Biophysical Research Communications. 414:425-430
Uracil–DNA glycosylase (Ung) is a DNA repair enzyme that excises uracil bases from DNA, where they appear through deamination of cytosine or incorporation from a cellular dUTP pool. DNA repair enzymes often use one-dimensional diffusion along DNA t