Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Grigory A. Efimov"'
Autor:
Saveliy A. Sheetikov, Alexandra A. Khmelevskaya, Ksenia V. Zornikova, Ivan V. Zvyagin, Alina S. Shomuradova, Yana V. Serdyuk, Naina T. Shakirova, Iuliia O. Peshkova, Aleksei Titov, Dmitrii S. Romaniuk, Irina A. Shagina, Dmitry M. Chudakov, Dmitry O. Kiryukhin, Olga V. Shcherbakova, Ekaterina G. Khamaganova, Vitalina Dzutseva, Andrei Afanasiev, Apollinariya V. Bogolyubova, Grigory A. Efimov
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Adenovirus vaccines, particularly the COVID-19 Ad5-nCoV adenovirus vaccine, have emerged as promising tools in the fight against infectious diseases. In this study, we investigated the structure of the T cell response to the Spike protein of the SARS
Externí odkaz:
https://doaj.org/article/c8dda62480a240ed83d72a7ba8d1b3ca
Autor:
Ksenia V. Zornikova, Alexandra Khmelevskaya, Savely A. Sheetikov, Dmitry O. Kiryukhin, Olga V. Shcherbakova, Aleksei Titov, Ivan V. Zvyagin, Grigory A. Efimov
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
The clonotypes of CD8+ T cells specific to 9 SARS-CoV-2 epitopes are identified from COVID-19 convalescent patients and the longitudinal study of these clonotypes reveals that T cell persistence correlates with TCR diversity.
Externí odkaz:
https://doaj.org/article/4dc9d57d7cbd4b779de5a7b2e6740e78
Autor:
Daichao Wu, Alexander Kolesnikov, Rui Yin, Johnathan D. Guest, Ragul Gowthaman, Anton Shmelev, Yana Serdyuk, Dmitry V. Dianov, Grigory A. Efimov, Brian G. Pierce, Roy A. Mariuzza
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Structural immunology is critical in understanding the interplay between the immune response and the infective agent but such studies in T cells and SARS-CoV-2 lag behind those of antibodies and B-cell receptors. Here the authors assess recognition o
Externí odkaz:
https://doaj.org/article/88ff2336853b4fc5ae388f4cc35fedd1
Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2
Autor:
Aleksei Titov, Regina Shaykhutdinova, Olga V. Shcherbakova, Yana V. Serdyuk, Savely A. Sheetikov, Ksenia V. Zornikova, Alexandra V. Maleeva, Alexandra Khmelevskaya, Dmitry V. Dianov, Naina T. Shakirova, Dmitry B. Malko, Maxim Shkurnikov, Stepan Nersisyan, Alexander Tonevitsky, Ekaterina Khamaganova, Anton V. Ershov, Elena Y. Osipova, Ruslan V. Nikolaev, Dmitry E. Pershin, Viktoria A. Vedmedskia, Michael Maschan, Victoria R. Ginanova, Grigory A. Efimov
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
The ongoing COVID-19 pandemic calls for more effective diagnostic tools. T cell response assessment serves as an independent indicator of prior COVID-19 exposure while also contributing to a more comprehensive characterization of SARS-CoV-2 immunity.
Externí odkaz:
https://doaj.org/article/f3a2a8cc553a465b87e4da680fdb63db
Autor:
Wesley Huisman, Lois Hageman, Didier A. T. Leboux, Alexandra Khmelevskaya, Grigory A. Efimov, Marthe C. J. Roex, Derk Amsen, J. H. Frederik Falkenburg, Inge Jedema
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Since multiple different T-cell receptor (TCR) sequences can bind to the same peptide-MHC combination and the number of TCR-sequences that can theoretically be generated even exceeds the number of T cells in a human body, the likelihood that many pub
Externí odkaz:
https://doaj.org/article/8c317c5f5ec342cead55f08d7667e8af
Autor:
Maria G. Byazrova, Sergey V. Kulemzin, Ekaterina A. Astakhova, Tatyana N. Belovezhets, Grigory A. Efimov, Anton N. Chikaev, Ilya O. Kolotygin, Andrey A. Gorchakov, Alexander V. Taranin, Alexander V. Filatov
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The development of effective vaccines against SARS-CoV-2 remains a global health priority. Despite extensive use, the effects of Sputnik V on B cell immunity need to be explored in detail. We performed comprehensive profiling of humoral and B cell re
Externí odkaz:
https://doaj.org/article/158ab0e960dd46d9ae4dd4d9e4fff3e3
Autor:
Dmitrii S. Romaniuk, Anna M. Postovskaya, Alexandra A. Khmelevskaya, Dmitry B. Malko, Grigory A. Efimov
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
A subset of MHC-associated self-peptides presented by the recipient's cells and immunologically foreign to the donor can induce an allogeneic immune response after hematopoietic stem cell transplantation (HSCT). These immunogenic peptides originate f
Externí odkaz:
https://doaj.org/article/872852d510c24bfc90bd94e79e855fb4
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is routinely used to treat hematopoietic malignancies. The eradication of residual tumor cells during engraftment is mediated by donor cytotoxic T lymphocytes reactive to alloantigens. In
Externí odkaz:
https://doaj.org/article/e590af605d484ff0bdedbacdfd103fc5
Autor:
Maxim A. Nosenko, Kamar-Sulu N. Atretkhany, Vladislav V. Mokhonov, Grigory A. Efimov, Andrey A. Kruglov, Sergei V. Tillib, Marina S. Drutskaya, Sergei A. Nedospasov
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions, their
Externí odkaz:
https://doaj.org/article/937fbf19f2fe463aa54a9611e61ef54d
Autor:
Ekaterina N. Gorshkova, Grigory A. Efimov, Ksenia D. Ermakova, Ekaterina A. Vasilenko, Diana V. Yuzhakova, Marina V. Shirmanova, Vladislav V. Mokhonov, Sergei V. Tillib, Sergei A. Nedospasov, Irina V. Astrakhantseva
Publikováno v:
Antibodies, Vol 7, Iss 4, p 43 (2018)
Upregulation of the expression of tumor necrosis factor (TNF-α, TNF) has a significant role in the development of autoimmune diseases. The fluorescent antibodies binding TNF may be used for personalized therapy of TNF-dependent diseases as a tool to
Externí odkaz:
https://doaj.org/article/c932b57ac3ec4c239f2f52d04e923ce1