Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Grigory, Ryzhakov"'
Autor:
Grigory Ryzhakov, Hannah Almuttaqi, Alastair L. Corbin, Dorothée L. Berthold, Tariq Khoyratty, Hayley L. Eames, Samuel Bullers, Claire Pearson, Zhichao Ai, Kristina Zec, Sarah Bonham, Roman Fischer, Luke Jostins-Dean, Simon P. L. Travis, Benedikt M. Kessler, Irina A. Udalova
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The transcription factor, IRF5, has been implicated in the regulation of inflammation, but how IRF5 protein is activated is still unclear. Here the authors use inhibitor library screening, biochemical analyses and in vivo/ex vivo data to show that a
Externí odkaz:
https://doaj.org/article/083b7a2470054dbf911ff4a0bab0a0ba
Autor:
Grigory Ryzhakov, Nathaniel R. West, Fanny Franchini, Simon Clare, Nicholas E. Ilott, Stephen N. Sansom, Samuel J. Bullers, Claire Pearson, Alice Costain, Alun Vaughan-Jackson, Jeremy A. Goettel, Joerg Ermann, Bruce H. Horwitz, Ludovico Buti, Xin Lu, Subhankar Mukhopadhyay, Scott B. Snapper, Fiona Powrie
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The Hiccs locus has been associated with susceptibility to colitis in mice. Here the authors identify a Hiccs locus gene encoding Alpha kinase 1 as a potent regulator of intestinal inflammation via modulation of the IL-12/Th1 axis.
Externí odkaz:
https://doaj.org/article/cd1515a1c0414a6e99b0e45f27672c4a
Autor:
Kristina Zec, Roman Fischer, Irina A. Udalova, Tariq E. Khoyratty, Claire Pearson, Hayley L. Eames, Benedikt M. Kessler, Hannah Almuttaqi, Grigory Ryzhakov, Simon Travis, Samuel J. Bullers, Luke Jostins-Dean, Alastair L. Corbin, Sarah Bonham, Zhichao Ai, Dorothée L. Berthold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, and has a key pathogenic function in gut inflammation, but how IRF5 is modulated is still unclear. Having performed a kinase inhibitor library screening in macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8cfb57ebeee917922ddd5935776e62
https://doi.org/10.1038/s41467-021-27038-5
https://doi.org/10.1038/s41467-021-27038-5
Autor:
Hayley L. Eames, Alastair L. Corbin, Grigory Ryzhakov, Hannah Almuttaqi, Zhichao Ai, Samuel J. Bullers, Dorothée L. Berthold, Simon Travis, Benedikt M. Kessler, Tariq E. Khoyratty, Roman Fischer, Irina A. Udalova, Luke Jostins-Dean, Sarah Bonham
Inflammatory bowel disease (IBD) is a group of inflammatory disorders of the gastro-intestinal tract caused by a complex combination of genetic and environmental factors. Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53eb597b4bc265c4753ba90752c274f6
https://doi.org/10.1101/2020.05.24.113076
https://doi.org/10.1101/2020.05.24.113076
Publikováno v:
PLoS Pathogens, Vol 4, Iss 2, p e22 (2008)
The IkappaB kinase (IKK) complex is a key regulator of signal transduction pathways leading to the induction of NF-kappaB-dependent gene expression and production of pro-inflammatory cytokines. It therefore represents a major target for the developme
Externí odkaz:
https://doaj.org/article/6212a675dfd24894a31a8d01ad3ab99e
Autor:
Camille, Danne, Grigory, Ryzhakov, Maria, Martínez-López, Nicholas Edward, Ilott, Fanny, Franchini, Fiona, Cuskin, Elisabeth C, Lowe, Samuel J, Bullers, J Simon C, Arthur, Fiona, Powrie
Publikováno v:
Microbial Cell
A high density of microbes inhabits the intestine, helping with food digestion, vitamin synthesis, xenobiotic detoxification, pathogen resistance and immune system maturation. Crucial for human health, communities of commensal bacteria (collectively
Autor:
Gerhard Müller-Newen, Johanna Pott, Dieter Görtz, C Cieluch, Travis Spl., Satish Keshav, Owens Bmj., Frédéric Baribaud, Samuel J. Bullers, Nathan R. West, Carrie Brodmerkel, Anja A. Kühl, S Plevy, K Stockenhuber, Raymond J. Owens, Kevin J. Maloy, Ahmed N. Hegazy, Fiona Powrie, Bryan Linggi, Nahid Rahman, Matthias Friedrich, S This, Grigory Ryzhakov, Sofia Buonocore, Margherita Coccia
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are complex chronic inflammatory conditions of the gastrointestinal tract that are driven by perturbed cytokine pathways. Anti-tumor necrosis factor-α (TN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1d943638f5891c64391bae955786e0
https://eprints.gla.ac.uk/198290/1/198290.pdf
https://eprints.gla.ac.uk/198290/1/198290.pdf
Autor:
Irina A. Udalova, Jiannis Ragoussis, Katrina Blazek, David Saliba, Grigory Ryzhakov, Tatsushi Muta, Ana Teixeira
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry; Vol 288
Journal of Biological Chemistry; Vol 288
Background: NF-κB regulates transcription via binding to DNA and interactions with cofactors. Results: NF-κB binding to DNA and cytosolic IκBs is conserved, whereas binding to nuclear IκBs has evolved. Conclusion: There is distinct evolutionary p
Autor:
Grigory Ryzhakov, Alessandra Lanfrancotti, Thomas Krausgruber, Irina A. Udalova, Hayley L. Eames, David Saliba
IRF5 plays a key role in the induction of pro-inflammatory cytokines, contributing to the plasticity and polarisation of macrophages to an M1 phenotype and initiation of a potent T(H)1-T(H)17 response. To better understand the means of IRF5 transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b5ac7b2372e08be082b70e621c2d0e
https://ora.ox.ac.uk/objects/uuid:dc6be787-e4b1-4638-96c9-c8cb25d2bb74
https://ora.ox.ac.uk/objects/uuid:dc6be787-e4b1-4638-96c9-c8cb25d2bb74
Publikováno v:
Journal of Molecular Evolution; Vol 72
SEF/IL-17R/CIKS/ACT1 homology (SEFIR) domain containing proteins, which include the IL-17 receptors and an adaptor protein Act1, have essential roles in vertebrate immunity. However, the molecular mechanisms of Act1 function remain largely unexplored