Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Grigoris Zoidis"'
Autor:
Erofili Giannakopoulou, Ifigeneia Akrani, George Mpekoulis, Efseveia Frakolaki, Marios Dimitriou, Vassilios Myrianthopoulos, Niki Vassilaki, Grigoris Zoidis
Publikováno v:
Viruses, Vol 16, Iss 8, p 1238 (2024)
Infections with Flaviviridae viruses, such as hepatitis C (HCV), dengue (DENV), and yellow fever (YFV) viruses, are major public health problems worldwide. In the case of HCV, treatment is associated with drug resistance and high costs, while there i
Externí odkaz:
https://doaj.org/article/34fb4d582add4d2e8640a88bb21fd38e
Autor:
Dimitrios Moianos, Maria Makri, Georgia-Myrto Prifti, Aristeidis Chiotellis, Alexandros Pappas, Molly E. Woodson, Razia Tajwar, John E. Tavis, Grigoris Zoidis
Publikováno v:
Molecules, Vol 29, Iss 12, p 2942 (2024)
Hepatitis B virus (HBV) remains a global health threat. Ribonuclease H (RNase H), part of the virus polymerase protein, cleaves the pgRNA template during viral genome replication. Inhibition of RNase H activity prevents (+) DNA strand synthesis and r
Externí odkaz:
https://doaj.org/article/92d2fc12da214c62bb8eb197a88cae60
Autor:
Vasiliki Pardali, Erofili Giannakopoulou, George Mpekoulis, Vassilina Tsopela, Georgios Panos, Martin C. Taylor, John M. Kelly, Niki Vassilaki, Grigoris Zoidis
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1046 (2023)
Flaviviridae infections, such as those caused by hepatitis C (HCV) and dengue viruses (DENVs), represent global health risks. Infected people are in danger of developing chronic liver failure or hemorrhagic fever, both of which can be fatal if not tr
Externí odkaz:
https://doaj.org/article/ed484c1d0d484c44a9f92e23cc06c013
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 901 (2023)
Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting me
Externí odkaz:
https://doaj.org/article/a8243f3f6ec14f17aff0f38ee27bd3f1
Publikováno v:
Molbank, Vol 2022, Iss 1, p M1353 (2022)
Based on previously highlighted structural features, the development of highly selective 5-HT1A receptor inhibitors is closely linked to the incorporation of a 4-alkyl-1-arylpiperazine scaffold on them. In this paper, we present the synthesis of two
Externí odkaz:
https://doaj.org/article/23ec3aa23c124227a9b01ba00f1a9875
Autor:
Elizabeth Geerling, Valerie Murphy, Maria C Mai, E Taylor Stone, Andreu Gazquez Casals, Mariah Hassert, Austin T O'Dea, Feng Cao, Maureen J Donlin, Mohamed Elagawany, Bahaa Elgendy, Vasiliki Pardali, Erofili Giannakopoulou, Grigoris Zoidis, Daniel V Schiavone, Alex J Berkowitz, Nana B Agyemang, Ryan P Murelli, John E Tavis, Amelia K Pinto, James D Brien
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274266 (2022)
Rift Valley fever virus (RVFV) is a veterinary and human pathogen and is an agent of bioterrorism concern. Currently, RVFV treatment is limited to supportive care, so new drugs to control RVFV infection are urgently needed. RVFV is a member of the or
Externí odkaz:
https://doaj.org/article/f63b08d6f3224485b760c43c8a67f8c2
Autor:
Tamer Nasr, Ahmed M. Aboshanab, George Mpekoulis, Antonios Drakopoulos, Niki Vassilaki, Grigoris Zoidis, Khaled A. M. Abouzid, Wafaa Zaghary
Publikováno v:
Viruses, Vol 14, Iss 12, p 2767 (2022)
Chronic hepatitis C virus (HCV) infections are a worldwide medical problem responsible for diverse types of liver diseases. The NS5B polymerase enzyme has become a very interesting target for the development of anti-HCV drugs owing to its fundamental
Externí odkaz:
https://doaj.org/article/21347f9737494097a34e238a7ef24399
Publikováno v:
Molbank, Vol 2021, Iss 2, p M1228 (2021)
A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed
Externí odkaz:
https://doaj.org/article/e5213cea7cb64ad792399638978a8839
Autor:
Alaa R. S. Leila, Mai H. A. Mousa, Efseveia Frakolaki, Niki Vassilaki, Ralf Bartenschlager, Grigoris Zoidis, Mohammad Abdel-Halim, Ashraf H. Abadi
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 11440-11454 (2019)
Externí odkaz:
https://doaj.org/article/7a00eab8e5f244e19ef67493fd0eefb6
Autor:
Argyro Vontzalidou, Sapfo-Maria Dimitrakoudi, Konstantinos Tsoukalas, Grigoris Zoidis, Eliza Chaita, Evanthia Dina, Christina Cheimonidi, Ioannis P. Trougakos, George Lambrinidis, Alexios-Leandros Skaltsounis, Emmanuel Mikros, Nektarios Aligiannis
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1593 (2022)
A number of stilbenoid and chalconoid derivatives were prepared by straightforward methods, and their ability to modulate tyrosinase activity and to scavenge free radicals were evaluated in vitro. The cell-free in vitro evaluation revealed two diaryl
Externí odkaz:
https://doaj.org/article/9c5d96933c874fb19f8eece6ae9d9ba5