Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Grigorij, Schleifer"'
Autor:
Bodil Petersen, Cornelius J. Busch, Grigorij Schleifer, Dominik Schaack, Felix Lasitschka, Kenneth D. Bloch, Donald B. Bloch, Fumito Ichinose
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric ox
Externí odkaz:
https://doaj.org/article/e25ed4aa6e604622aeec12eafb54322b
Autor:
Lauren K. Wareham, Ana C. Dordea, Grigorij Schleifer, Vincent Yao, Annabelle Batten, Fei Fei, Joseph Mertz, Meredith Gregory-Ksander, Louis R. Pasquale, Emmanuel S. Buys, Rebecca M. Sappington
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 65-75 (2019)
The nitric oxide – guanylyl cyclase-1 – cyclic guanylate monophosphate (NO-GC-1–cGMP) pathway has emerged as a potential pathogenic mechanism for glaucoma, a common intraocular pressure (IOP)-related optic neuropathy characterized by the degene
Externí odkaz:
https://doaj.org/article/92a4bcd054ac4d3387fd86f1ecf77dac
Autor:
Wittmann, Claudia Neumann, Nadine Straßberger-Nerschbach, Achilles Delis, Johannes Kamp, Alexandra Görtzen-Patin, Dishalen Cudian, Andreas Fleischer, Götz Wietasch, Mark Coburn, Ehrenfried Schindler, Grigorij Schleifer, Maria
Publikováno v:
Healthcare; Volume 11; Issue 13; Pages: 1942
Background: Digitalization in the health system is a topic that is rapidly gaining popularity, and not only because of the current pandemic. As in many areas of daily life, digitalization is becoming increasingly important in the medical field amid t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::b4ecb7a3ab02a3b034b00b13b0322560
Autor:
Claudia Neumann, Nadine Strassberger-Nerschbach, Achilles Delis, Johannes Kamp, Alexandra Görtzen-Patin, Dishalen Cudian, Andreas Fleischer, Götz Wietasch, Mark Coburn, Ehrenfried Schindler, Grigorij Schleifer, Maria Wittmann
Background Digitalisation in the health system is a topic that is rapidly gaining popularity, not only because of the current pandemic. As in many areas of daily life, digitalisation is becoming increasingly important in the medical field amid the ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa07c9a879919a2ef775a575c999fe0b
https://doi.org/10.21203/rs.3.rs-2021983/v1
https://doi.org/10.21203/rs.3.rs-2021983/v1
Autor:
Rajeev Malhotra, Bryn Reinstadler, Aranya Bagchi, Daniel Bloch, Hardik Shah, Fumito Ichinose, Robert M. H. Grange, Eizo Marutani, Gregory R. Wojtkiewicz, Vamsi K. Mootha, Marissa K. Cooper, Yusuke Miyazaki, Grigorij Schleifer, Allyson G. Hindle, Akito Nakagawa, Warren M. Zapol, Olga Goldberger, Rohit Sharma, Annabelle Batten
Publikováno v:
Molecular Genetics and Metabolism. 133:83-93
Leigh syndrome is a severe mitochondrial neurodegenerative disease with no effective treatment. In the Ndufs4−/− mouse model of Leigh syndrome, continuously breathing 11% O2 (hypoxia) prevents neurodegeneration and leads to a dramatic extension (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8dfb0c48990bb2740cda981f0aec86
https://doi.org/10.1016/j.ymgme.2021.03.005
https://doi.org/10.1016/j.ymgme.2021.03.005
An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance
Autor:
Russell P. Goodman, Yusuke Miyazaki, Anupam Patgiri, Rohit Sharma, Warren M. Zapol, Owen S. Skinner, Eizo Marutani, Grigorij Schleifer, Hardik Shah, Tsz-Leung To, Xiaoyan Robert Bao, Vamsi K. Mootha, Fumito Ichinose
Publikováno v:
Nature biotechnology
An elevated intracellular NADH:NAD+ ratio, or 'reductive stress', has been associated with multiple diseases, including disorders of the mitochondrial electron transport chain. As the intracellular NADH:NAD+ ratio can be in near equilibrium with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4742667995ae5732cbf3c007f51a936b
https://doi.org/10.1038/s41587-019-0377-7
https://doi.org/10.1038/s41587-019-0377-7
Autor:
Robert M H, Grange, Rohit, Sharma, Hardik, Shah, Bryn, Reinstadler, Olga, Goldberger, Marissa K, Cooper, Akito, Nakagawa, Yusuke, Miyazaki, Allyson G, Hindle, Annabelle J, Batten, Gregory R, Wojtkiewicz, Grigorij, Schleifer, Aranya, Bagchi, Eizo, Marutani, Rajeev, Malhotra, Donald B, Bloch, Fumito, Ichinose, Vamsi K, Mootha, Warren M, Zapol
Publikováno v:
Mol Genet Metab
Leigh syndrome is a severe mitochondrial neurodegenerative disease with no effective treatment. In the Ndufs4(−/−) mouse model of LS, continuously breathing 11% O(2) (hypoxia) prevents neurodegeneration and leads to a dramatic extension (~5-fold)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0267752dcaa19019458cf3a795f5b069
https://pubmed.ncbi.nlm.nih.gov/33752971
https://pubmed.ncbi.nlm.nih.gov/33752971
Autor:
Fei Fei, Ana C. Dordea, Grigorij Schleifer, Lauren K. Wareham, Meredith S Gregory-Ksander, Annabelle Batten, Emmanuel S. Buys, Rebecca M. Sappington, Joseph L. Mertz, Vincent Yao, Louis R. Pasquale
Publikováno v:
Neurobiology of Disease, Vol 121, Iss, Pp 65-75 (2019)
The nitric oxide – guanylyl cyclase-1 – cyclic guanylate monophosphate (NO-GC-1–cGMP) pathway has emerged as a potential pathogenic mechanism for glaucoma, a common intraocular pressure (IOP)-related optic neuropathy characterized by the degene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab692faa7a6e0e5146fa5b018f760989
http://www.sciencedirect.com/science/article/pii/S096999611830202X
http://www.sciencedirect.com/science/article/pii/S096999611830202X
Autor:
Robert M. H. Grange, Olga Goldberger, Eizo Marutani, Rohit Sharma, Michele Ferrari, Owen S. Skinner, Warren M. Zapol, Martin Wepler, Grigorij Schleifer, Kathryn M. Peneyra, Daniel Bloch, Fumito Ichinose, Rajeev Malhotra, Vamsi K. Mootha
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
Hypoxic pulmonary vasoconstriction (HPV) is a physiological vasomotor response that maintains systemic oxygenation by matching perfusion to ventilation during alveolar hypoxia. Although mitochondria appear to play an essential role in HPV, the impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acb8dccee94783d3a395cc14af31d4d
http://europepmc.org/articles/PMC6397345
http://europepmc.org/articles/PMC6397345
Autor:
Daniel Bloch, Warren M. Zapol, Michele Ferrari, Marissa K. Cooper, Qiukan Chen, Elizabeth S. Klings, Lorenzo Berra, Binglan Yu, Faik N. Musayev, Grigorij Schleifer, Martin K. Safo, Akito Nakagawa, Osheiza Abdulmalik, Ronni S. Safo, Chen Liu
Publikováno v:
Molecular Pharmaceutics
Sickle cell disease is an inherited disorder of hemoglobin (Hb). During a sickle cell crisis, deoxygenated sickle hemoglobin (deoxyHbS) polymerizes to form fibers in red blood cells (RBCs), causing the cells to adopt “sickled” shapes. Using small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2224b7a18f3c187e92c40826977f83e
http://europepmc.org/articles/PMC5942180
http://europepmc.org/articles/PMC5942180