Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Grigorii V. Andrianov"'
Autor:
Ilya G. Serebriiskii, Valerii A. Pavlov, Grigorii V. Andrianov, Samuel Litwin, Stanley Basickes, Justin Y. Newberg, Garrett M. Frampton, Joshua E. Meyer, Erica A. Golemis
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected
Externí odkaz:
https://doaj.org/article/05b5d8139d0048c0b81f41974e799bcd
Publikováno v:
J Chem Inf Model
In early stage drug discovery, the hit-to-lead optimization (or “hit expansion”) stage entails starting from a newly-identified active compound, and improving its potency or other properties. Traditionally this process relies on synthesizing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccbd886bef7ae46367691b3791e5650
https://europepmc.org/articles/PMC8865965/
https://europepmc.org/articles/PMC8865965/
Autor:
Max Yates, John Karanicolas, Nan Bai, Palani Kirubakaran, Grigorii V. Andrianov, Sven A. Miller
Publikováno v:
J Chem Inf Model
Proteolysis-targeting chimaeras (PROTACs) are molecules that combine a target-binding warhead with an E3 ligase-recruiting moiety; by drawing the target protein into a ternary complex with the E3 ligase, PROTACs induce target protein degradation. Whi