Výsledky vyhledávání - "Grigor S. Simitian"

Akademický článek

Consequences of anastomotic leaks after minimally invasive esophagectomy: A single-center experience

Autor: Grigor S. Simitian, BS, David J. Hall, MD, Glen Leverson, PhD, Entela B. Lushaj, MD, PhD, Erik E. Lewis, MD, Kelsey A. Musgrove, MD, Daniel P. McCarthy, MD, James D. Maloney, MD

Publikováno v: Surgery Open Science, Vol 11, Iss , Pp 26-32 (2023)

Background: Anastomotic leak (AL) after minimally invasive esophagectomy (MIE) is a well-described source of morbidity for patients undergoing surgical treatment of esophageal neoplasm. With improved early recognition and endoscopic management techni

Externí odkaz: https://doaj.org/article/d2e292e006f2456899ea246f6cea7c99

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In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways

Autor: Grigor S. Simitian, Jean-Baptiste Garsi, Stephen Hanessian, Aimee L. Edinger, Vito Vece, Lorenzo Sernissi, Alison N. McCracken

A series of compounds containing pyrrolidine and pyrrolizidine cores with appended hydrophobic substituents were prepared as constrained analogs of FTY720 and phytosphingosine. The effect of these compounds on the viability of cancer cells, on downre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa651aff0ba68cc91e08896155f79e4
https://europepmc.org/articles/PMC6217821/

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Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death

Autor: Grigor S. Simitian, Matheus P. Viana, Seong M. Kim, Aimee L. Edinger, Heather O’Donoghue, Susanne M. Rafelski, Dean G. Nguyen, Alison N. McCracken, Timothy Wiher, Michael S. Perryman, Jérémie Tessier, Stephen Hanessian

Publikováno v: Bioorganicmedicinal chemistry. 24(18)

Constrained analogs containing a 2-hydroxymethylpyrrolidine core of the natural sphingolipids sphingosine, sphinganine, N,N-dimethylsphingosine and N-acetyl variants of sphingosine and sphinganine (C2-ceramide and dihydro-C2-ceramide) were synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7165c43de8f8d0c73ffc9cd007585c
https://pubmed.ncbi.nlm.nih.gov/27475534

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