FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

Autor: Brevini, Teresa, Maes, Mailis, Webb, Gwilym J, John, Binu V, Fuchs, Claudia Daniela, Buescher, Gustav, Wang, Lu, Griffiths, Chelsea, Brown, Marnie L, Scott 3rd, William E, Pereyra-Gerber, Pehuen, Gelson, William T H, Brown, Stephanie, Dillon, Scott, Muraro, Danielle, Sharp, Jo, Neary, Megan, Box, Helen, Tatham, Lee, Stewart, James, Hagstrøm, Hannes, Melum, Espen, Barritt 4th, Alfred S, Gupta, Ravindra K., Baker, Stephen, Davenport, Antony P, Corbett, Gareth, Gorgoulis, Vassilis G, Bauzacki, Simon J A, Lee, Joo-Hyeon, Matheson, Nicholas J, Trauner, Michael, Fisher, Andrew J, Gibbs, Paul, Butler, Andrew J., Watson, Christopher J E, Mells, Georg F, Dougan, Gordon, Owen, Andrew, Lohse, Ansgar W., Vallier, Ludovic, Sampaziotis, Fotios

Publikováno v: Brevini, Teresa Maes, Mailis Webb, Gwilym J John, Binu V Fuchs, Claudia Daniela Buescher, Gustav Wang, Lu Griffiths, Chelsea Brown, Marnie L Scott 3rd, William E Pereyra-Gerber, Pehuen Gelson, William T H Brown, Stephanie Dillon, Scott Muraro, Danielle Sharp, Jo Neary, Megan Box, Helen Tatham, Lee Stewart, James Hagstrøm, Hannes Melum, Espen Barritt 4th, Alfred S Gupta, Ravindra K. Baker, Stephen Davenport, Antony P Corbett, Gareth Gorgoulis, Vassilis G Bauzacki, Simon J A Lee, Joo-Hyeon Matheson, Nicholas J Trauner, Michael Fisher, Andrew J Gibbs, Paul Butler, Andrew J. Watson, Christopher J E Mells, Georg F Dougan, Gordon Owen, Andrew Lohse, Ansgar W. Vallier, Ludovic Sampaziotis, Fotios . FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022
Nature

Externí odkaz: http://hdl.handle.net/10852/100985

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FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

Autor: Brevini T; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. tb647@cam.ac.uk., Maes M; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Webb GJ; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., John BV; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA., Fuchs CD; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Buescher G; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Wang L; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Griffiths C; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Brown ML; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Scott WE 3rd; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Pereyra-Gerber P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Gelson WTH; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Brown S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Dillon S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Muraro D; Wellcome Sanger Institute, Hinxton, UK., Sharp J; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Neary M; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Box H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Tatham L; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Stewart J; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Curley P; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Pertinez H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Forrest S; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Mlcochova P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA., Varankar SS; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Darvish-Damavandi M; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Mulcahy VL; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK., Kuc RE; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Williams TL; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Heslop JA; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Rossetti D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Tysoe OC; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Galanakis V; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Vila-Gonzalez M; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Crozier TWM; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Bargehr J; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Sinha S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Fear C; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Swift L; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Davies SE; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Wester A; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden., Hagström H; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden., Melum E; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Hybrid Technology Hub Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway., Clements D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Humphreys P; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Herriott J; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Kijak E; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Cox H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Bramwell C; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Valentijn A; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Illingworth CJR; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.; Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK., Dahman B; Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA., Bastaich DR; Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA., Ferreira RD; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA., Marjot T; Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK., Barnes E; Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK., Moon AM; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA., Barritt AS 4th; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA., Gupta RK; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Baker S; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Davenport AP; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Corbett G; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Gorgoulis VG; Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Buczacki SJA; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Lee JH; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.; NHS Blood and Transplant, Cambridge, UK., Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Fisher AJ; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Gibbs P; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Butler AJ; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Watson CJE; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre, and the NIHR Blood and Transplant Research Unit (BTRU) at the University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT), Cambridge, UK., Mells GF; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK., Dougan G; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Owen A; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Lohse AW; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Vallier L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. ludovic.vallier@bih-charite.de.; Wellcome Sanger Institute, Hinxton, UK. ludovic.vallier@bih-charite.de.; Berlin Institute of Health (BIH), BIH Centre for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Berlin, Germany. ludovic.vallier@bih-charite.de.; Max Planck Institute for Molecular Genetics, Berlin, Germany. ludovic.vallier@bih-charite.de., Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. fs347@cam.ac.uk.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. fs347@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. fs347@cam.ac.uk.

Publikováno v: Nature [Nature] 2023 Mar; Vol. 615 (7950), pp. 134-142. Date of Electronic Publication: 2022 Dec 05.