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Translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system active drugs.

Autor: Ferreira GS; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Dijkstra FM; Centre for Human Drug Research, Leiden, The Netherlands. fdijkstra@chdr.nl.; Leiden University Medical Centre, Leiden, The Netherlands. fdijkstra@chdr.nl., Veening-Griffioen DH; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Boon WPC; Copernicus Institute of Sustainable Development, Innovation Studies, Utrecht University, Utrecht, The Netherlands., Schellekens H; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Moors EHM; Copernicus Institute of Sustainable Development, Innovation Studies, Utrecht University, Utrecht, The Netherlands., van Meer PJK; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Medicines Evaluation Board (CBG), Utrecht, The Netherlands., Stuurman FE; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., van Gerven JMA; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.; Central Committee on Research Involving Human Subjects (CCMO), Leiden, The Netherlands.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2023 Mar 01; Vol. 13 (1), pp. 74. Date of Electronic Publication: 2023 Mar 01.

Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy.

Autor: Alashkar Alhamwe B; Institute of Laboratory Medicine, the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, 35039 Marburg, Germany.; Institute of Tumor Immunology, Clinic for Hematology, Oncology and Immunology, Center for Tumor Biology and Immunology, Philipps University Marburg, 35039 Marburg, Germany.; College of Pharmacy, International University for Science and Technology (IUST), Daraa 15, Syria., Meulenbroek LAPM; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CT Utrecht, The Netherlands., Veening-Griffioen DH; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CT Utrecht, The Netherlands., Wehkamp TMD; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CT Utrecht, The Netherlands., Alhamdan F; Institute of Laboratory Medicine, the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, 35039 Marburg, Germany.; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35039 Marburg, Germany., Miethe S; Institute of Laboratory Medicine, the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, 35039 Marburg, Germany.; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35039 Marburg, Germany., Harb H; Institute of Laboratory Medicine, the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, 35039 Marburg, Germany.; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA., Hogenkamp A; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CT Utrecht, The Netherlands., Knippels LMJ; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CT Utrecht, The Netherlands., Pogge von Strandmann E; Institute of Tumor Immunology, Clinic for Hematology, Oncology and Immunology, Center for Tumor Biology and Immunology, Philipps University Marburg, 35039 Marburg, Germany., Renz H; Institute of Laboratory Medicine, the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, 35039 Marburg, Germany., Garssen J; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CT Utrecht, The Netherlands., van Esch BCAM; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CT Utrecht, The Netherlands., Garn H; Institute of Laboratory Medicine, the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, 35039 Marburg, Germany.; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35039 Marburg, Germany., Potaczek DP; Institute of Laboratory Medicine, the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, 35039 Marburg, Germany.; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35039 Marburg, Germany.; John Paul II Hospital, 31-202 Krakow, Poland., Tiemessen MM; Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CT Utrecht, The Netherlands.

Publikováno v: Nutrients [Nutrients] 2020 Oct 19; Vol. 12 (10). Date of Electronic Publication: 2020 Oct 19.

Levelling the Translational Gap for Animal to Human Efficacy Data.

Autor: Ferreira GS; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3512 JE Utrecht, The Netherlands., Veening-Griffioen DH; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3512 JE Utrecht, The Netherlands., Boon WPC; Copernicus Institute of Sustainable Development, Innovation Studies, Utrecht University, 3512 JE Utrecht, The Netherlands., Moors EHM; Copernicus Institute of Sustainable Development, Innovation Studies, Utrecht University, 3512 JE Utrecht, The Netherlands., van Meer PJK; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3512 JE Utrecht, The Netherlands.; Medicines Evaluation Board, 3531 AH Utrecht, The Netherlands.

Publikováno v: Animals : an open access journal from MDPI [Animals (Basel)] 2020 Jul 15; Vol. 10 (7). Date of Electronic Publication: 2020 Jul 15.

Correction: A standardised framework to identify optimal animal models for efficacy assessment in drug development.

Autor: Ferreira GS, Veening-Griffioen DH, Boon WPC, Moors EHM, Gispen-de Wied CC, Schellekens H, van Meer PJK

Publikováno v: PloS one [PLoS One] 2019 Jul 22; Vol. 14 (7), pp. e0220325. Date of Electronic Publication: 2019 Jul 22 (Print Publication: 2019).