Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Grietje, Molema"'
Autor:
Zhendong Wang, Erna-Zulaikha Dayang, Peter J. Zwiers, Martha L. Hernandez Garcia, Matthijs Luxen, Matijs van Meurs, Jill Moser, Jan A. A. M. Kamps, Grietje Molema
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1672 (2024)
Background: Sepsis is an uncontrolled systemic inflammatory response to an infection that can result in acute failure of the function of the lung called acute respiratory distress syndrome. Leukocyte recruitment is an important hallmark of acute lung
Externí odkaz:
https://doaj.org/article/297b7db8f4564ec48c473d9d8bde37c7
Autor:
Audrey Cleuren, Grietje Molema
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
In the last decades, it has become evident that endothelial cells (ECs) in the microvasculature play an important role in the pathophysiology of sepsis-associated multiple organ dysfunction syndrome (MODS). Studies on how ECs orchestrate leukocyte re
Externí odkaz:
https://doaj.org/article/1b25737eed5d4e3d8505d810f7114033
Autor:
Anoek L I van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A M Dekker, Marjolein R A van der Steen, Joris J T H Roelofs, Matijs van Meurs, Grietje Molema, Charissa E van den Brom
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0293673 (2023)
BackgroundThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into
Externí odkaz:
https://doaj.org/article/2ac4c83dd5644c58a18fa8b1e6658a17
Autor:
Sophie F. Ellermann, Rianne M. Jongman, Matthijs Luxen, Timara Kuiper, Josee Plantinga, Jill Moser, Thomas W. L. Scheeren, Gregor Theilmeier, Grietje Molema, Matijs Van Meurs
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Major surgery induces systemic inflammation leading to pro-inflammatory activation of endothelial cells. Endothelial inflammation is one of the drivers of postoperative organ damage, including acute kidney injury Tumour Necrosis Factor alpha (TNF-α)
Externí odkaz:
https://doaj.org/article/cf25c4bc3adc4a79a97601512bf31bd1
Autor:
Peter J. Zwiers, Jacqueline P. F. E. Lucas, Rianne M. Jongman, Matijs van Meurs, Eliane R. Popa, Grietje Molema
Publikováno v:
Cells, Vol 12, Iss 14, p 1850 (2023)
Endothelial cells (ECs) in the microvasculature in organs are active participants in the pathophysiology of sepsis. Tyrosine protein kinase receptor Tie2 (Tek; Tunica interna Endothelial cell Kinase) is thought to play a role in their inflammatory re
Externí odkaz:
https://doaj.org/article/11b6b9db5f9f4453bbffe80e08ab5adc
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Sepsis is a devastating clinical condition that can lead to multiple organ failure and death. Despite advancements in our understanding of molecular mechanisms underlying sepsis and sepsis-associated multiple organ failure, no effective therapeutic t
Externí odkaz:
https://doaj.org/article/9ff91488c0d8492e93efd85d8d671782
Autor:
Mahdi Garelnabi, Mitzy Cowdin, Yun Fang, Bandana Shrestha, Masuko Ushio-Fukai, Elena Aikawa, Garth Graham, Grietje Molema, Hiromi Yanagisawa, Masanori Aikawa
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Recent increased visibility on racial issues in the United States elicited public outcry and a collective call for action. The social justice movement has facilitated energetic discussions about race, sexual orientation, and various issues of diversi
Externí odkaz:
https://doaj.org/article/1fdd089078b147abad3126c2e5d6fc24
Autor:
Peter J. Zwiers, Rianne M. Jongman, Timara Kuiper, Jill Moser, Radu V. Stan, Joachim R. Göthert, Matijs van Meurs, Eliane R. Popa, Grietje Molema
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Tyrosine-protein kinase receptor Tie2, also known as Tunica interna Endothelial cell Kinase or TEK plays a prominent role in endothelial responses to angiogenic and inflammatory stimuli. Here we generated a novel inducible Tie2 knockout mouse model,
Externí odkaz:
https://doaj.org/article/87343e3da24d4f7fb9bde788a5e7c178
Autor:
Susanna Skalicky, Peter J Zwiers, Timara Kuiper, Elisabeth Schraml, Matthias Hackl, Grietje Molema
Publikováno v:
BioTechniques, Vol 67, Iss 6, Pp 276-285 (2019)
Neglecting tissue heterogeneity during the analysis of microRNA (miRNA) levels results in average signals from an unknown mixture of different cell types that are difficult to interpret. Here we demonstrate the technical requirements needed to obtain
Externí odkaz:
https://doaj.org/article/6ede8c10699f4dd4a558f7dcfd18bd3e
Autor:
Yutong He, Dongdong Bi, Josée A. Plantinga, Grietje Molema, Jeroen Bussmann, Jan A. A. M. Kamps
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2086 (2022)
Low transfection efficiency in endothelial cells (EC) is still a bottleneck for the majority of siRNA-based vascular delivery approaches. In this work, we developed a lipid-based nanoparticle (LNP) formulation based on a combination of a permanently
Externí odkaz:
https://doaj.org/article/03a3b92baaa74d51979c188c05f4a036