Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gricelda Hernandez"'
Autor:
Jerome F. Daanen, Joseph P. Mikusa, Chih Hung Lee, Chengmin Zhong, Jason A. Segreti, Patrick W. Mantyh, Torben R. Neelands, Patricia N. Banfor, Michael F. Jarvis, Arthur Gomtsyan, Prasant Chandran, Molly A. Sevcik, Philip R. Kym, Donna M. Gauvin, Regina M. Reilly, Kennan C. Marsh, Michael E. Kort, Connie R. Faltynek, James P. Sullivan, Erol K. Bayburt, Carol S. Surowy, Joseph R. Ghilardi, Prisca Honore, Gricelda Hernandez, Ryan M. Fryer, Shailen K. Joshi
Publikováno v:
Pain. 142:27-35
Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a variety of putative endogenous lipid ligands. TRPV1 antagonists have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26cec77f1eb7a5454a08a328e395101
https://doi.org/10.1016/j.pain.2008.11.004
https://doi.org/10.1016/j.pain.2008.11.004
Autor:
Matthew S Johnson, Dong Liu, Robert J. Gregg, Irene Drizin, Michael F. Gross, Gricelda Hernandez, Kennan C. Marsh, James B. Thomas, Mark L. Chapman, Chang Z. Zhu, Brian E. Marron, Connie R. Faltynek, Shailen K. Joshi, Prisca Honore, Stephen Werness, Michael E. Kort, Douglas S. Krafte, Robert N. Atkinson, Rosemarie Roeloffs, William A. Carroll, Marc J. C. Scanio, Xu-Feng Zhang, Donna M. Gauvin, Michael J. Krambis, Michael F. Jarvis, Char-Chang Shieh, Lei Shi, Joseph P. Mikusa
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6379-6386
The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is reported. Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3) as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdfd333e1e1c8103d37b0c3b7e0a15f
https://doi.org/10.1016/j.bmc.2008.05.003
https://doi.org/10.1016/j.bmc.2008.05.003
Autor:
Chang Z. Zhu, Peter R. Hollingsworth, Donna M. Gauvin, Sonya G. Lehto, Renjie Chang, Prisca Honore, Jorge D. Brioni, Scott J. Baker, Gricelda Hernandez, GuoZhu Zheng, Robert B. Moreland, Odile EI-Kouhen, Andrew O. Stewart
Publikováno v:
European Journal of Pharmacology. 580:314-321
Activation of metabotropic glutamate (mGlu) receptors has previously been shown to play a role in inflammatory or neuropathic pain states. However, the role of mGlu type 1 receptors in post-operative pain remains to be investigated. In the present st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc7c4bfb04efdede560e59d69f8a707
https://doi.org/10.1016/j.ejphar.2007.09.047
https://doi.org/10.1016/j.ejphar.2007.09.047
Autor:
William A Carroll, Chengmin Zhong, Stephen Werness, Jinrong Liu, Matthew S Johnson, Lei Shi, Michael F Jarvis, James B. Thomas, Xu-Feng Zhang, Mark L. Chapman, Michael F. Gross, Shailen Joshi, Michael E. Kort, Marc J. C. Scanio, Dong Liu, Robert J Gregg, Rosemarie Roeloffs, Prisca Honore, Gricelda Hernandez, Gregory J Pacofsky, Douglas S. Krafte, Robert N. Atkinson, Brian E. Marron, Irene I. Drizin, Kennan C Marsh, Joseph P Mikusa, Michael J. Krambis, Bernard P Murray, Char-Chang Shieh, Connie R. Faltynek
Publikováno v:
Journal of Medicinal Chemistry. 51:407-416
Nav1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory neurons and has been implicated in the pathophysiology of inflammatory and neuropathic pain. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4dee5ae6db88bda78289080d9f0fe12
https://doi.org/10.1021/jm070637u
https://doi.org/10.1021/jm070637u
Autor:
Prasant Chandran, Gricelda Hernandez, Michael W. Decker, Shailen K. Joshi, C.T. Wismer, Prisca Honore, C.Z. Zhu, Anita K. Salyers, C. Zhong, Joseph P. Mikusa
Publikováno v:
Neuroscience. 143:587-596
Intradermal capsaicin injection produces immediate spontaneous pain behaviors, and a secondary mechanical hypersensitivity (SMH) that is employed in the clinic as a model potentially predictive of human neuropathic pain. Presently, we have characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd3b2733659bd33554653ac6f00f13c
https://doi.org/10.1016/j.neuroscience.2006.08.005
https://doi.org/10.1016/j.neuroscience.2006.08.005
Autor:
Torben R. Neelands, C. Zhong, Erol K. Bayburt, B. Brown, Prisca Honore, Joseph P. Mikusa, W. Niforatos, Donna M. Gauvin, Gricelda Hernandez, H. McDonald, Michael W. Decker, Robert B. Moreland, Arthur Gomtsyan, Kennan C. Marsh, B. Bianchi, Prasant Chandran, Connie R. Faltynek, James P. Sullivan, C.-H. Lee, M. Cui
Publikováno v:
The Journal of Neuroscience. 26:9385-9393
Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0d962b3ad79f4a5ab44823bdc3504b
https://doi.org/10.1523/jneurosci.1246-06.2006
https://doi.org/10.1523/jneurosci.1246-06.2006
Autor:
Joseph P. Mikusa, Prisca Honore, Gricelda Hernandez, Karen Kage, Wende Niforatos, Char-Chang Shieh, Torben R. Neelands, Michael F. Jarvis, S.K. Joshi, Xu-Feng Zhang, Ping Han, Connie R. Faltynek, James P. Sullivan, Scott J. Baker, Douglas S. Krafte
Publikováno v:
Pain. 123:75-82
Antisense (AS) oligodeoxynucleotides (ODNs) targeting the Nav 1.8 sodium channel have been reported to decrease inflammatory hyperalgesia and L5/L6 spinal nerve ligation-induced mechanical allodynia in rats. The present studies were conducted to furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebe463587933aa120d7f01b256841e2
https://doi.org/10.1016/j.pain.2006.02.011
https://doi.org/10.1016/j.pain.2006.02.011
Autor:
Michael E. Kort, Prisca Honore, Marc J. C. Scanio, Arthur Gomtsyan, Robert G. Schmidt, Michael F. Jarvis, S.K. Joshi, Gricelda Hernandez
Publikováno v:
The journal of pain. 10(3)
Evidence implicating Nav1.8 and TRPV1 ion channels in various chronic pain states is extensive. In this study, we used isobolographic analysis to examine the in vivo effects of the combination of the Nav1.8 blocker A-803467 [5-(4-Chloro-phenyl)-furan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3d76d65f133ca7ce92ed72966ba92a
https://pubmed.ncbi.nlm.nih.gov/19070548
https://pubmed.ncbi.nlm.nih.gov/19070548
Autor:
Char Chang Shieh, P. Kay Wagoner, Robert J. Gregg, Connie R. Faltynek, James P. Sullivan, Steve McGaraughty, James Thomas, Joseph P. Mikusa, Xu Feng Zhang, Prisca Honore, William A. Carroll, Carrie Wade, Matthew D. Johnson, Dong Liu, Marc J. C. Scanio, Donna M. Gauvin, Michael J. Krambis, Madhavi Pai, Ahmed A. Hakeem, Yi Liu, Brian E. Marron, Chengmin Zhong, Chang Zhu, Irene Drizin, Lei Shi, Michael E. Kort, Mark A. Matulenko, Kennan C. Marsh, Mark L. Chapman, Michael F. Jarvis, Rosemarie Roeloffs, Katharine L. Chu, Robert N. Atkinson, Gricelda Hernandez, Shailen K. Joshi, Douglas S. Krafte, Michael L. Gross
Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed against Na v 1.8 have shown that this channel contributes to experimental inflammatory and neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b96a940a48639fdc2f7861032c77d96
https://europepmc.org/articles/PMC1895982/
https://europepmc.org/articles/PMC1895982/
Autor:
Richard R. Harris, Prasant Chandran, Connie R. Faltynek, Chengmin Zhong, James P. Sullivan, William A. Carroll, Diana L. Donnelly-Roberts, Joe Mikusa, Donna M. Gauvin, Prisca Honore, Chang Z. Zhu, Gricelda Hernandez, Arturo Perez Medrano, Michael F. Jarvis, Marian T. Namovic, Kennan C. Marsh, Gin C. Hsieh
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 319(3)
ATP-sensitive P2X(7) receptors are localized on cells of immunological origin including glial cells in the central nervous system. Activation of P2X(7) receptors leads to rapid changes in intracellular calcium concentrations, release of the proinflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f19fd768691f5e59e97abfc336bc76
https://pubmed.ncbi.nlm.nih.gov/16982702
https://pubmed.ncbi.nlm.nih.gov/16982702